Li, Hongdong Jiang, Fengle Du, Yuhui Li, Na Chen, Zhihong Cai, Hao Guo, You Hong, Guini
Published in
Epigenetics
Leukocyte cell proportion changes affect the detection of cancer-associated aberrant DNA methylation alterations in peripheral blood samples. We aimed to detect cellular DNA methylation changes in ovarian cancer (OVC) blood samples avoiding the above-mentioned cell-composition effects. Based on the within-sample relative methylation orderings (RMOs...
Wong, Yen Ting Tayeb, Michael A Stone, Timothy C Lovat, Laurence B Teschendorff, Andrew E Iwasiow, Rafal Craig, Jeffrey M
Published in
Epigenetics
Saliva and buccal samples are popular for epigenome wide association studies (EWAS) due to their ease of collection compared and their ability to sample a different cell lineage compared to blood. As these samples contain a mix of white blood cells and buccal epithelial cells that can vary within a population, this cellular heterogeneity may confou...
Fulton, Melody D Dang, Tran Brown, Tyler Zheng, Y George
Published in
Epigenetics
Histone arginine methylation is a prevalent posttranslational modification (PTM) in eukaryotic cells and contributes to the histone codes for epigenetic regulation of gene transcription. In this study, we determined how local changes on adjacent residues in the histone H4 substrate regulate arginine asymmetric dimethylation and symmetric dimethylat...
Sallam, Magy Benotmane, Mohammed Abderrafi Baatout, Sarah Guns, Pieter-Jan Aerts, An
Published in
Epigenetics
Radiotherapy in cancer treatment involves the use of ionizing radiation for cancer cell killing. Although radiotherapy has shown significant improvements on cancer recurrence and mortality, several radiation-induced adverse effects have been documented. Of these adverse effects, radiation-induced cardiovascular disease (CVD) is particularly promine...
Rocks, Devin Jaric, Ivana Tesfa, Lydia Greally, John M Suzuki, Masako Kundakovic, Marija
Published in
Epigenetics
The Assay for Transposase Accessible Chromatin by sequencing (ATAC-seq) is becoming popular in the neuroscience field where chromatin regulation is thought to be involved in neurodevelopment, activity-dependent gene regulation, hormonal and environmental responses, and pathophysiology of neuropsychiatric disorders. The advantages of using ATAC-seq ...
Wang, Ya Perera, Frederica Guo, Jia Riley, Kylie W Durham, Teresa Ross, Zev Ananth, Cande V Baccarelli, Andrea Wang, Shuang Herbstman, Julie B
...
Published in
Epigenetics
A barrier in the children's environmental health field has been the lack of early-warning systems to identify risks of childhood illness and developmental disorders. We aimed to develop a methodology to identify an accessible biomarker measured in a small amount of blood to distinguish newborns at elevated risk from a toxic prenatal exposure, using...
Andersen, Allan Reimer, Rachel Dawes, Kelsey Becker, Ashley Hutchens, Natasha Miller, Shelly Dogan, Meesha Hundley, Brandon A Mills, James D Long, Jeffrey
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Published in
Epigenetics
Increasing use of non-combusted forms of nicotine such as e-cigarettes poses important public health questions regarding their specific risks relative to combusted tobacco products such as cigarettes. To fully delineate these risks, improved biomarkers that can distinguish between these forms of nicotine use are needed. Prior work has suggested tha...
Danilova, Ludmila Wrangle, John Herman, James G Cope, Leslie
Published in
Epigenetics
The contribution of DNA-methylation based gene silencing to carcinogenesis is well established. Increasingly, DNA-methylation is examined using genome-wide techniques, with recent public efforts yielding immense data sets of diverse malignancies representing the vast majority of human cancer related disease burden. Whereas mutation events may group...
Laplana, Marina Bieg, Matthias Faltus, Christian Melnik, Svitlana Bogatyrova, Olga Gu, Zuguang Muley, Thomas Meister, Michael Dienemann, Hendrik Herpel, Esther
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Published in
Epigenetics
Genome-wide association studies (GWAS) have identified SNPs linked with lung cancer risk. Our aim was to discover the genes, non-coding RNAs, and regulatory elements within GWAS-identified risk regions that are deregulated in non-small cell lung carcinoma (NSCLC) to identify novel, clinically targetable genes and mechanisms in carcinogenesis. A tar...
Shim, Sangrea Lee, Hong Gil Park, Ok-Sun Shin, Hosub Lee, Kyounghee Lee, Hongwoo Huh, Jin Hoe Seo, Pil Joon
Published in
Epigenetics
Plant somatic cells can be reprogrammed into pluripotent cell mass, called callus, through a two-step in vitro tissue culture method. Incubation on callus-inducing medium triggers active cell proliferation to form a pluripotent callus. Notably, DNA methylation is implicated during callus formation, but a detailed molecular process regulated by DNA ...
