Ute Rößler Elisabeth Thomassen Lothar Hütner Stefan Baier Joana Danescu Anne Katrin Werenskiold
Published in
Developmental Biology
Abstract The murine T1 gene encodes a membrane-bound glycoprotein (T1-M), highly similar to interleukin-1 (IL-1) receptor type I, and a soluble variant (T1-S) representing its isolated extracellular domain. In vivo, the expression pattern of both T1 isoforms differs drastically. The T1-M receptor is abundantly expressed in single cells of the major...
Lee Meisel Shaoping Xie Eric Lam
Published in
Developmental Biology
Abstract An important question in developmental biology concerns the mechanisms by which a few cells coordinate division and differentiation to yield the complex structures and organs found in multicellular organisms. During vegetative growth in plants, cells in the apical meristem must coordinate division and differentiation to yield the fully mat...
Hashimoto, Yoshiko Maegawa, Shingo Nagai, Terumi Yamaha, Etsuro Suzuki, Hitoshi Yasuda, Kunio Inoue, Kunio
Published in
Developmental Biology
Maternally supplied factors in fertilized eggs play essential roles in the establishment of primordial germ cells. In zebrafish, cytoplasm at the distal ends of the first and second cleavage furrows has been assumed to contain germ lineage determinants, since maternal transcripts of germ lineage-specific genes are localized to ends of the cleavage ...
Navaline Quach Thomas A. Rando
Published in
Developmental Biology
A central question in muscle biology is how costameres are formed and become aligned with underlying myofibrils in mature tissues. Costameres are composed of focal adhesion proteins, including vinculin and paxillin, and anchor myofibril Z-bands to the sarcolemma. In the present study, we investigated the process of costamere formation (" costamerog...
Kleinjan, Dirk A Seawright, Anne Mella, Sebastien Carr, Catherine B Tyas, David A Simpson, T Ian Mason, John O Price, David J van Heyningen, Veronica
Published in
Developmental biology
Pax6 is a developmental control gene with an essential role in development of the eye, brain and pancreas. Pax6, as many other developmental regulators, depends on a substantial number of cis-regulatory elements in addition to its promoters for correct spatiotemporal and quantitative expression. Here we report on our analysis of a set of mice trans...
Quinn, Jane C Molinek, Michael Martynoga, Ben S Zaki, Paulette A Faedo, Andrea Bulfone, Alessandro Hevner, Robert F West, John D Price, David J
Published in
Developmental biology
Many cerebral cortical neurons and glia are produced by apical progenitors dividing at the ventricular surface of the embryonic dorsal telencephalon. Other neurons are produced by basal progenitor cells, which are derived from apical progenitors, dividing away from the ventricular surface. The transcription factor Pax6 is expressed in apical progen...
Strutt, David Strutt, Helen
Published in
Developmental biology
During planar polarity patterning of the Drosophila wing, a "core" group of planar polarity genes has been identified which acts downstream of global polarity cues to locally coordinate cell polarity and specify trichome production at distal cell edges. These genes encode protein products that assemble into asymmetric apicolateral complexes that st...
Howard, Laura Rex, Maria Clements, Debbie Woodland, Hugh R
Published in
Developmental biology
The gene encoding the Sox F-group transcription factor Xsox17alpha(1) is specifically expressed throughout the entire region of the Xenopus blastula fated to become endoderm, and is important in controlling endodermal development. Xsox17alpha(1) is a direct target of the maternal endodermal determinant VegT and of Sox17 itself. We have analysed the...
Peterkin, Tessa Gibson, Abigail Patient, Roger
Published in
Developmental biology
The transcription factors, GATA4, 5 and 6, recognize the same DNA sequence and are all expressed in the developing myocardium. However, knockout studies in the mouse have indicated that none of them are absolutely required for the specification of the myocardium. Here we present evidence for redundancy in this family for the first time. Using morph...
Guan, Wei Wang, Guoying Scott, Sheryl A Condic, Maureen L
Published in
Developmental biology
The molecular mechanisms responsible for specifying the dorsal-ventral pattern of neuronal identities in dorsal root ganglia (DRG) are unclear. Here we demonstrate that Sonic hedgehog (Shh) contributes to patterning early DRG cells. In vitro, Shh increases both proliferation and programmed cell death (PCD). Increasing Shh in vivo enhances PCD in do...
