Kaneda, Yuki Miyata, Haruhiko Shimada, Keisuke Oyama, Yuki Iida-Norita, Rie Ikawa, Masahito
Published in
Developmental biology
Immunity-related GTPases (IRGs), also known as p47 GTPases, are a family of interferon-inducible proteins that play roles in immunity defense against intracellular pathogens. Although the molecular functions of IRGs have been well studied, the function of the family member, IRGC1, remains unclear. IRGC1 is unique among IRGs because its expression i...
Godden, Alice M Antonaci, Marco Ward, Nicole J van der Lee, Michael Abu-Daya, Anita Guille, Matthew Wheeler, Grant N
Published in
Developmental biology
In recent years CRISPR-Cas9 knockouts (KO) have become increasingly ultilised to study gene function. MicroRNAs (miRNAs) are short non-coding RNAs, 20-22 nucleotides long, which affect gene expression through post-transcriptional repression. We previously identified miRNAs-196a and -219 as implicated in the development of Xenopus neural crest (NC)....
Wu, Jun Barbaric, Ivana
Published in
Developmental Biology
• Cell selection might play a role in human embryo development. • Pluripotent stem cells provide a platform for studying human development. • Cell competition occurs in human pluripotent stem cell cultures. • Cell competition is a barrier to interspecies chimerism.
Neal, Alice Nornes, Svanhild Louphrasitthiphol, Pakavarin Sacilotto, Natalia Preston, Mark D. Fleisinger, Lucija Payne, Sophie De Val, Sarah
Published in
Developmental Biology
• Vein-specific enhancers can contain essential ETS motifs. • VEGFA induced an increase in ETS binding at vein, arterial and angiogenic enhancers. • VEGFA stimulation cannot induce vein-specific enhancer activity.
Kula-Alwar, Duvaraka Marber, Michael S. Hughes, Simon M. Hinits, Yaniv
Published in
Developmental Biology
• Live image analysis showed extensive growth in zebrafish heart between 3 and 5 dpf. • Proliferation, hypertrophy and addition of external CM progenitors contribute to heart growth. • Reduced Mef2c activity, downstream or in parallel with Nkx2.5 and upstream of Ltbp3, diminishes growth resulting in a smaller ventricle by 3 dpf. • SHF CM contributi...
Zupanc, Günther K H Lehotzky, Dávid Tripp, Isabel P
Published in
Developmental biology
Until very recently, distance education, including digital science labs, served a rather small portion of postsecondary students in the United States and many other countries. This situation has, however, dramatically changed in 2020 in the wake of the COVID-19 pandemic, which forced colleges to rapidly transit from face-to-face instructions to onl...
Alshami, Ilham J J Ono, Yosuke Correia, Ana Hacker, Christian Lange, Anke Scholpp, Steffen Kawasaki, Masashi Ingham, Philip W Kudoh, Tetsuhiro
Published in
Developmental biology
South American Gymnotiform knifefish possess electric organs that generate electric fields for electro-location and electro-communication. Electric organs in fish can be derived from either myogenic cells (myogenic electric organ/mEO) or neurogenic cells (neurogenic electric organ/nEO). To date, the embryonic development of EOs has remained obscure...
Kroll, Jason R. Tsiaxiras, Jasonas van Zon, Jeroen S.
Published in
Developmental Biology
• The fate of the C. elegans P3.p cell is stochastic. • β-catenin (BAR-1) accumulated in P3.p at the time of the cell fate decision. • There is variability in dynamics of Hox and β-catenin levels during the decision. • BAR-1 accumulated with variable pulse slope and time of pulse onset. • Pulse dynamics bias cell fate at the time of the cell fate d...
Gilbert, Sophie P R Mullan, Thomas W Poole, Richard J Woollard, Alison
Published in
Developmental biology
Strikingly, epithelial morphogenesis remains incomplete at the end of C. elegans embryonic development; newly hatched larvae undergo extensive remodelling of their ventral epidermis during the first larval stage (L1), when newly-born epidermal cells move ventrally to complete the epidermal syncytium. Prior to this remodelling, undivided lateral sea...
Cohn, Jesse A Cebul, Elizabeth R Valperga, Giulio Brose, Lotti de Bono, Mario Heiman, Maxwell G Pierce, Jonathan T
Published in
Developmental biology
Neuronal activity often leads to alterations in gene expression and cellular architecture. The nematode Caenorhabditis elegans, owing to its compact translucent nervous system, is a powerful system in which to study conserved aspects of the development and plasticity of neuronal morphology. Here we focus on one pair of sensory neurons, termed URX, ...
