Gao, Min Li, Hang Lv, Xiaoting Zhou, Baosen Yin, Zhihua
Published in
DNA and cell biology
Long noncoding RNAs (lncRNAs) play important roles in the development of human cancers. This is the first case-control study of the association between specific polymorphisms in lncRNA genes and the risk of lung cancer, as well as the gene-environment interaction between the polymorphisms and cooking oil fume exposure in Chinese never-smoking femal...
Shah, Syed Fawad Ali Iqbal, Tahir Qamar, Raheel Rafiq, Muhammad Arshad Hussain, Sabir
Published in
DNA and cell biology
The purpose of this study is to investigate the association of variant alleles (rs2781666 and rs2781667) at ARG1 to be involved in the generation of essential hypertension (EH) phenotypes in human subjects. The ARG1 noncoding polymorphisms (rs2781666; Chr6:131572419-G/T and rs2781667; Chr6:131573754-C/T) were investigated in 570 subjects, including...
Yuan, Jingyi Zeng, Jiali Shuai, Chun Liu, Yue
Published in
DNA and cell biology
Gastric cancer has a high incidence and mortality in the world, especially in China. The pathogenesis leading to the high heterogeneity of gastric cancer remains unclear. It is believed that TWSG1 is associated with a variety of tumors, but there are few studies related to gastric cancer. To investigate the biological significance of TWSG1, we eval...
Wong, Cheung Pang Xu, Zaikun Power, Christopher Hobman, Tom C
Published in
DNA and cell biology
Peroxisomes are membrane-bound organelles that are best known for their roles in lipid metabolism. Mounting evidence indicates that they are also important nodes for antiviral signaling. While research over the past few decades has revealed effective viral strategies to block antiviral signalling pathways from the plasma membrane, mitochondria and/...
Wang, Gang Zhang, Lijuan Wang, Hefeng Cui, Mingyu Liu, Wei Liu, Yang Wu, Xiangyu
Published in
DNA and cell biology
Hirschsprung disease (HSCR) is congenital intestinal aganglionosis attributed to a failure to migrate and survive of neural crest-derived cells. Glial cell-derived neurotrophic factor alpha 4 (GFRA4) is expressed in the derivatives of the neural crest in the enteric nervous system, but whether it is related with HSCR still remains unclear. This stu...
Zhang, Qinghai Chen, Ling Zhao, Zhibo Wu, Ying Zhong, Jing Wen, Gebo Cao, Renxian Zu, Xuyu Liu, Jianghua
Published in
DNA and cell biology
High-mobility group protein A1 (HMGA1), an architectural transcription factor, was found to regulate multiple gene expression in mammals. Recent studies firmly indicate an association between HMGA1 and type 2 diabetes. However, the presence and function of HMGA1 in diabetic vasculopathy has not been substantiated. in this study, we first determined...
Wang, Linya Ou, Jing-Hsiung James
Published in
DNA and cell biology
Macroautophagy, hereafter autophagy, is a catabolic process that is important for maintaining cellular homeostasis. It can also be used by cells to remove intracellular microbial pathogens. However, the studies on hepatitis C virus (HCV) in recent years indicated that this virus could regulate this cellular pathway and use it to enhance its replica...
Pélisse, Mélanie Der Vartanian, Audrey Germot, Agnès Maftah, Abderrahman
Published in
DNA and cell biology
The protein O-glucosyltransferase 1 (Poglut1) links O-glucose to epidermal growth factor-like repeats harboring the C1XSX(P/A)C2 consensus sequence. Poglut1 is a ubiquitous endoplasmic reticulum-resident protein largely found in metazoans, but only about 50 proteins possess this consensus sequence. Among them, Notch receptors have multiple O-glucos...
Tian, Wen Li, Yong-Sheng Zhang, Jing-Hua Li, Ji-Jun Gao, Jing-Hua
Published in
DNA and cell biology
Due to the high mortality of lung cancer, early diagnosis followed by early effective treatment is the key to prognosis improvement, which demands to identify the biological targets. Therefore, a multistage screening analysis was used to identify biological targets of lung adenocarcinoma. Two independent datasets of DNA methylation and RNA expressi...
Wang, Rong Sun, Xuan Deng, Yong-Shu Qiu, Xu-Wen
Published in
DNA and cell biology
The alterations in P-glycoprotein (P-gp)-mediated transport of antipsychotics due to the ABCB1 1199G>A polymorphism were assessed in the current study. The ABCB1wt and ABCB11199A recombinant cell models were constructed to study the sensitivity, intracellular accumulation, and transepithelial permeability of antipsychotic drugs. ABCB11199A recombin...
