Yu, Jing-Song Leng, Peng-Fei Li, Yi-Fu Wang, Yong-Quan Wang, Yan An, Rui-Hua Qi, Ji-Ping
Published in
DNA and cell biology
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that interacts with multiple signaling pathways during prostate development. In the present study, LNCaP cells were knocked down of AhR by siRNA, or treated with the AhR agonist 3-methylcholanthrene (3MC). The effects of AhR on LNCaP cells and the associated mechanisms were ...
Huang, Tonghai Wang, Guangsuo Yang, Lin Peng, Bin Wen, Yuxin Ding, Guanggui Wang, Zheng
Published in
DNA and cell biology
Lung cancer is the leading cause of cancer-related death worldwide. Despite the advancement in surgery and chemotherapy, the prognosis of patients with advanced lung cancer is still poor. Yin Yang-1 (YY1) is a multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes. In this stud...
Huang, Zhi-Wen Tian, Li-Hong Yang, Bin Guo, Run-Min
Published in
DNA and cell biology
Cardiac fibrosis is closely related to multiple cardiovascular system diseases, and noncoding RNAs (ncRNAs), including long noncoding RNA (lncRNA) and microRNA (miRNA), have been reported to play a vital role in fibrogenesis. The present study aims to investigate the potential regulatory mechanism of lncRNA H19 and miR-455 on fibrosis-associated pr...
Zhao, Hongjing Wang, Yu Liu, Juanjuan Shao, Yizhi Li, Jinglun Chai, Hongliang Xing, Mingwei
Published in
DNA and cell biology
DNA and Cell Biology (DNA&CB) is officially retracting the paper by Zhao H, Wang Y, Liu J, Shao Y, Li J, Chai H, Xing M, entitled, "Molecular Characterization and Biological activity of Interferon-α in Indian Peafowl (Pavo cristatus)," [Epub ahead of print]; 2017, DOI: 10.1089/dna.2017.3798. The Editor-in-Chief of DNA&CB, Dr. Carol Shoshkes Reiss, ...
Wu, Di Xie, Feng Xiao, Ling Feng, Fen Huang, Shifang He, Lu Liu, Meiqing Zhou, Qun Li, Lanfang Chen, Linxi
...
Published in
DNA and cell biology
Apelin, an endogenous ligand for apelin receptor (APJ), is reported to be involved in cardiomyocyte hypertrophy. In this study, we explored the mechanism of cardiomyocyte hypertrophy induced by apelin-13/APJ system. Left ventricular hypertrophy (LVH) rat model was established by constricting the abdominal aorta. Western blots were used for protein ...
Jiang, Yonghua Han, Kunhuang Cai, Mingyi Wang, Yilei Zhang, Ziping
Published in
DNA and cell biology
As one of transcription factors and pluripotency factors, Klf4 plays a crucial role in regulation of cellular processes. In this article, we characterized Klf4 of large yellow croaker (Lc-Klf4), which encodes a 452-amino acid protein (Lc-Klf4) with three highly conserved C2H2 zinc fingers. Lc-Klf4 shares high conservative functions in teleosts with...
Krupa, Renata Czarny, Piotr Wigner, Paulina Wozny, Joanna Jablkowski, Maciej Kordek, Radzislaw Szemraj, Janusz Sliwinski, Tomasz
Published in
DNA and cell biology
The molecular mechanism of hepatocellular carcinoma (HCC) is related to DNA damage caused by oxidative stress products induced by hepatitis B virus (HBV) or C (HCV) infection and exposure to environmental pollutants. Single-nucleotide polymorphisms (SNPs) of DNA damage response (DDR) genes may influence individual susceptibility to environmental ri...
Jiang, Xue Liu, Weiwei
Published in
DNA and cell biology
Dysfunction of lncRNA has been found in the nasopharyngeal carcinoma (NPC); however, the effect of lncRNA expression on NPC tumorigenesis as well as the molecular mechanism of lncRNA in the pathogenesis of NPC remain largely unknown. In this study, we showed that highly upregulated in liver cancer (HULC), the first identified lncRNA in hepatocellul...
Yang, Anning Sun, Yue Gao, Yuan Yang, Songhao Mao, Caiyan Ding, Ning Deng, Mei Wang, Yanhua Yang, Xiaoling Jia, Yuexia
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Published in
DNA and cell biology
DNA methyltransferase 1 (DNMT1) and miRNAs are both important regulators of gene expression that have been implicated in the pathogenesis of atherosclerosis. This study was designed to elucidate the potential interaction between DNMT1 and miRNAs in the context of hyperhomocysteinemia (HHcy)-related atherosclerosis. In the aorta of ApoE-/- mice fed ...
Kumar, Suresh Beena, Ananda Sankara Awana, Monika Singh, Archana
Published in
DNA and cell biology
Plants have evolved several strategies, including regulation of genes through epigenetic modifications, to cope with environmental stresses. DNA methylation is dynamically regulated through the methylation and demethylation of cytosine in response to environmental perturbations. High-affinity potassium transporters (HKTs) have accounted for the hom...
