Zurita-Cruz, Jessie N Villasís-Keever, Miguel A Manuel-Apolinar, Leticia Damasio-Santana, Leticia Gutierrez-Gonzalez, Alejandro Wakida-Kusunoki, Guillermo Padilla-Rojas, Michel Maldonado-Rivera, Cesar Garrido-Magaña, Eulalia Rivera-Hernández, Aleida de J
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Published in
Cytokine
To compare cardiometabolic factors and adipokines between patients with recently diagnosed CPP and controls without CPP, paired by BMI Z scores (BMIz) and classified into girls with adequate nutritional status and girls who are overweight or obese. This cross-sectional study was performed from January 2012 to May 2015 at two tertiary care pediatric...
Baars, Iris Lokau, Juliane Sauerland, Ina Müller, Andreas J. Garbers, Christoph
Published in
Cytokine
Interleukin-11 (IL-11) is an important member of the IL-6 family of cytokines. IL-11 activates its target cells via binding to a non-signaling α-receptor (IL-11R), which results in recruitment and activation of a gp130 homodimer. The cytokine was initially described as an anti-inflammatory protein, but has recently gained attention as a potent driv...
Chibber, Pankaj Haq, Syed Assim Kumar, Anil Kumar, Chetan Gupta, Divya Wazir, Priya Singh, Surjeet Abdullah, Sheikh Tasduq Singh, Gurdarshan
Published in
Cytokine
Arthritis, a primary autoimmune disorder having a global incidence of 2.03% person/year, is presently being treated by many commercially available drugs that treat symptomatically or improve the disease's clinical state; however, all the therapies pose varying amount of side effects. Therefore, it has become a fundamental need to search for therape...
Tang, Zhan-Li Zhang, Kai Lv, Shao-Cong Xu, Gui-Wen Zhang, Jian-Fen Jia, Hai-Yan
Published in
Cytokine
Psoriasis is a common chronic inflammatory skin disorder that causes patches of thick red skin and silvery scales and affects 1-3% of the population, which reduces patient's quality of life. Understanding the pathogenesis of psoriasis is crucial for developing novel therapeutic strategies. HaCaT and NHEK cells were treated with TNF-α in vitro. A mo...
Sarma, U Maiti, M Nair, A Bhadange, S Bansode, Y Srivastava, A Saha, B Mukherjee, D
Published in
Cytokine
The pro-inflammatory IFNγ-STAT1 pathway and anti-inflammatory IL10-STAT3 pathway elicit cellular responses primarily utilizing their canonical STATs. However IL10 mediated STAT1 and IFNγ mediated STAT3 activation is also observed, suggesting crosstalk of these functionally opposing signaling pathways can potentially reshape the canonical dynamics b...
Bharmal, Sakina H Kimita, Wandia Ko, Juyeon Petrov, Maxim S
Published in
Cytokine
Acute inflammation of the pancreas often leads to metabolic sequelae, the most common of which is new-onset prediabetes (and, ultimately, diabetes). However, there is a lack of studies on predictors of this sequela. The aim was to investigate whether cytokines/chemokines measured at baseline are predictive of new-onset prediabetes after acute pancr...
Fernandez-Botran, Rafael Furmanek, Stephen Ambadapoodi, Raghava Sekhar Expósito González, Evelyn Cahill, Meredith Carrico, Ruth Akca, Ozan Ramírez, Julio A.
Published in
Cytokine
This study analyzed the levels at admission of biomarkers for their association with and ability to predict risk of severe outcomes, including admission to the ICU, need for invasive mechanical ventilation (IMV), need for vasopressor use (VU), and in-hospital mortality (IHM) in 700 patients hospitalized with COVID-19. Biomarker data split by outcom...
Hursitoglu, Mehmet Isıksacan, Nilgun Erismis, Betul Karandere, Faruk Kural, Alev Kumbasar, A.Baki Kart Yasar, Kadriye
Published in
Cytokine
Background To determine and compare nasopharyngeal microbiota (NM) composition, in vitro basal (Nil tube), provoked (Mitogen tube) production of cytokines at the early stage of COVID-19. Methods This cross-sectional study included 4 age and sex-matched study groups; group 1 (recovered COVID-19) (n = 26), group 2 (mild COVID-19) (n = 24), group 3 (s...
Jafarzadeh, Abdollah Jafarzadeh, Sara Sharifi, Iraj Aminizadeh, Najmeh Nozari, Parvin Nemati, Maryam
Published in
Cytokine
Infection with the same species of Leishmania (L)donovani causes different manifestations including visceral leishmaniasis (VL) and post kala-azar dermal leishmaniasis (PKDL), indicating that the host-related immunological parameters perform a decisive role in the pathogenesis of diseases. As PKDL is a reservoir of the parasite, a better understand...
Bhor, Renuka Rafati, Sima Pai, Kalpana
Published in
Cytokine
In humans, infection with Leishmania manifests into a spectrum of diseases. The manifestation of the diseases depend on the resultant evasion of the parasite to immune responses namely by macrophages, which is an exclusive host of Leishmania. The B cells valiantly mount antibody responses, however, to no avail as the Leishmania parasites occupy the...
