Misra, Sanchaita Mondal, Sumantro Chatterjee, Sulagna Dutta, Satarupa Sinha, Debanjali Bhattacharjee, Dipanjan Lahiri, Debasish Ghosh, Alakendu
Published in
Cytokine
To compare the level of pro and anti-inflammatory cytokines, and angiogenic mediators between Rheumatoid arthritis (RA) patients with and without subclinical synovitis (SS) in remission state, to find the correlation of these mediators with Greyscale synovitis (GSS) and power Doppler (PD) scores, and to find the probable predictor/s of SS. 52 RA pa...
Xie, Zhijuan Wei, Lanji Chen, Jianying Chen, Zhong
Published in
Cytokine
Long noncoding RNAs (lncRNAs) are significant regulators for sepsis-associated acute kidney injury (AKI). Noncoding RNA activated by DNA damage (NORAD) is highly expressed in the serum of patients with neonatal sepsis. We aimed to reveal the role of NORAD in sepsis-associated AKI. In this study, we established an AKI mouse model by cecal ligation a...
Alves Mota, Camila Stéfanie Sara Lopes Lera-Nonose, Daniele... Ávila Brustolin, Aline Chiqueto Duarte, Giovanna Carolina Mota Dos Santos, Maria Valdrinez Campana Lonardoni, Maria Gomes Verzignassi Silveira, Thaís
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Cytokine
Leishmania (Viannia) species are the major agents of cutaneous leishmaniasis (CL) in the Americas. Ulcerative stigmatizing skin lesions generally characterize CL. The microenvironment during Leishmania infection is rich in inflammatory cells and molecules, which contrasts with low oxygen levels. The hypoxia-inducible factor (HIF)-1α activates sever...
Matsushima, Kouji Yang, De Oppenheim, Joost J
Published in
Cytokine
Early in the 1980s several laboratories mistakenly reported that partially purified interleukin-1 (IL-1) was chemotactic for neutrophils. However, further investigations by us, revealed that our purified IL-1 did not have neutrophil chemotactic activity and this activity in the LPS-stimulated human monocyte conditioned media could clearly be separa...
Liu, Ning Jiang, Fan Ye, Mulin Wang, Bangjie Ge, Dongsheng Chang, Shunwu
Published in
Cytokine
Human gastric cancer is a leading cause of cancer mortality in the world wide. We found that the expression of IL-17a was significantly increased in gastric cancer cells. Treatment with recombinant IL-17a (rIL-17a) can increase migration, invasion and epithelial to mesenchymal transition (EMT) of gastric cancer cells. Further, Snail, a key factor t...
Sghaier, Ikram Mouelhi, Leila Rabia, Noor A Ghazoueni, Ezzedine Almawi, Wassim Y Loueslati, Besma Yacoubi
Published in
Cytokine
Interleukin-10 (IL-10) plays an important role in the immunity to hepatitis C virus (HCV). Insofar as IL-10 variants are associated with altered levels of IL-10, previous studies that examined the association of IL-10 polymorphisms with the susceptibility to and progression of chronic HCV, and response to anti-viral treatment were inconsistent. We ...
Bergantini, Laura d'Alessandro, Miriana Cameli, Paolo Otranto, Ambra Luzzi, Simona Bianchi, Francesco Bargagli, Elena
Published in
Cytokine
Coronavirus disease 2019 (COVID-19) is an infectious respiratory disorder caused by a new coronavirus called SARS-CoV-2. The pathophysiology of severe COVID-19 is associated with a "cytokine storm". IL-32 is a key modulator in the pathogenesis of various clinical conditions and is mostly induced by IL-8. IL-32 modulates important inflammatory pathw...
Borges, Leandro Dermargos, Alexandre Hatanaka, Elaine
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Cytokine
Enzyme-linked Immunosorbent Assays (ELISAs) techniques are widely known for the robust signal amplification with high sensitivity and specificity for the quantitation of antibodies and antigens in complex biological fluids. However, strict caution in the pre-analytical, analytical, and post-analytical phases is crucial to warrant an immunoassay qua...
Todorović-Raković, Nataša
Published in
Cytokine
The evolution of malignant cells implies an increase in oncogenic fitness of cells which arises in active and reciprocal interaction with the tumor microenvironment. The mechanisms facilitating the adaptive evolution of cancer cells involve clonal selection of cancer cells, in a direction of increased adaptive potential under the selective pressure...
Guimarães Sousa, Stefany Kleiton de Sousa, Antônio Maria Carvalho Pereira, Cynthia Sofia Miranda Loiola Araújo, Anna de Aguiar Magalhães, Diva Vieira de Brito, Tarcisio Barbosa, André Luiz dos Reis
Published in
Cytokine
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the newly emerging lung disease pandemic COVID-19. This viral infection causes a series of respiratory disorders, and although this virus mainly infects respiratory cells, the small intestine can also be an important site of entry or interaction, as enterocytes h...