Singh, Rakesh Kumar Najmi, Abul Kalam
Published in
Current drug targets
The primary focus of this review is to highlight the current and emerging proinflammatory role of MK2 kinase signaling in p38MAPK pathway and to provide a detailed evaluation on the prospects of MK2 inhibition with special emphasis on the etiology of chronic inflammatory airway diseases, such as asthma, idiopathic pulmonary fibrosis, lung cancer, a...
Zhang, Lei Hussain, Zahid Ren, Zhuanqin
Published in
Current drug targets
Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess Cerebrospinal Fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, slurred speech, impaired decision making and critical thinking, and loss of bladder and bowl...
Mohsen, Amira Mohamed
Published in
Current drug targets
Medications currently available for the management of diabetes mellitus are inconvenient and have some limitations. Thus, investigations for novel approaches are needed to deliver and target antidiabetics safely to the site of action. The present review emphasizes the limitations of conventional antidiabetics and provides the recent progresses of n...
Polonio-Alcalá, Emma Rabionet, Marc Ruiz-Martínez, Santiago Ciurana, Joaquim Puig, Teresa
Published in
Current drug targets
Breast Cancer (BC) is the most common cancer among women and the second cause of female death for cancer. When the tumor is not correctly eradicated, there is a high relapse risk and incidence of metastasis. Breast Cancer Stem Cells (BCSCs) are responsible for initiating tumors and are resistant to current anticancer therapies being in part respons...
Gautam, Lalit Kumar Sharma, Prince Capalash, Neena
Published in
Current drug targets
Bacterial infections have always been an unrestrained challenge to the medical community due to the rise of multi-drug tolerant and resistant strains. Pioneering work on Escherichia coli polyphosphate kinase (PPK) by Arthur Kornberg has generated great interest in this polyphosphate (PolyP) synthesizing enzyme. PPK has wide distribution among patho...
Argollo, Marjorie Kotze, Paulo Gustavo Lamonaca, Laura Gilardi, Daniela Furfaro, Federica Yamamoto, Takayuki Danese, Silvio
Published in
Current drug targets
Crohn's disease (CD) is an immune-mediated condition characterized by the transmural inflammation of the gut tissue, associated with progressive bowel damage often leading to surgical intervention. As operative resection of the damaged segment is not curative, a majority of patients undergoing intestinal resections for complicated CD present diseas...
Malik, Neelam Dhiman, Priyanka Khatkar, Anurag
Published in
Current drug targets
Curcumin is a well-known pharmacophore and some of its derivatives are shown to target xanthine oxidase (XO) to alleviate disorders caused by the excess production of uric acid. Curcumin based derivatives were designed, synthesized and evaluated for their antioxidant and xanthine oxidase inhibitory potential. In this report, we designed and synthes...
Gong, Jianting Chen, Yongbing Pu, Feng Sun, Pingping He, Fei Zhang, Li Li, Yanwen Ma, Zhiqiang Wang, Han
Published in
Current drug targets
Membrane proteins play crucial physiological roles in vivo and are the major category of drug targets for pharmaceuticals. The research on membrane protein is a significant part in the drug discovery. The biological process is a cycled network, and the membrane protein is a vital hub in the network since most drugs achieve the therapeutic effect vi...
Huang, Liangliang Li, Binbin Li, Xiang Liu, Ge Liu, Rui Guo, Jia Xu, Baohui Li, Yunman Fang, Weirong
Published in
Current drug targets
P-glycoprotein (P-gp) is a member of ATP-Binding Cassette (ABC) transporter family. Because of its characteristic luminal surface location, high transport potency and structural specificity, Pgp is regarded as a selective gatekeeper of the Blood Brain Barrier (BBB) to prevent the entry of toxins or unwanted substances into the brain. In recent year...
Wang, Xiaotong Han, Zhenbo Yu, Ying Xu, Zihang Cai, Benzhi Yuan, Ye
Published in
Current drug targets
Owning the high incidence and disability rate in the past decades, to be expected, cardiovascular diseases (CVDs) have become one of the leading death causes worldwide. Currently, induced pluripotent stem cells (iPSCs), with the potential to form fresh myocardium and improve the functions of damaged hearts, have been studied widely in experimental ...
