Wang, Xiongfei Li, Tianfu
Published in
Current drug targets
Epilepsy, an ancient disease, is defined as an enduring predisposition to generate epileptic seizures and by the neurobiological, cognitive, psychological, and social consequences of this condition. Antiepileptic drugs (AEDs) are currently used as first-line treatment for patients with epilepsy; however, around 36% of patients are diagnosed with re...
Spirina, Liudmila V Avgustinovich, Alexandra V Afanas'ev, Sergey G Cheremisina, Olga V Volkov, Maxim Yu Choynzonov, Evgeny L Gorbunov, Alexey K Usynin, Evgeny A
Published in
Current drug targets
Gastric cancer (GC) is biologically and genetically heterogeneous with complex carcinogenesis at the molecular level. Despite the application of multiple approaches in the GC treatment, its 5-year survival is poor. A major limitation of anti-cancer drugs application is intrinsic or acquired resistance, especially to chemotherapeutical agents. It is...
Li, Kening Du, Yuxin Li, Lu Wei, Dong-Qing
Published in
Current drug targets
Drug discovery is important in cancer therapy and precision medicines. Traditional approaches of drug discovery are mainly based on in vivo animal experiments and in vitro drug screening, but these methods are usually expensive and laborious. In the last decade, omics data explosion provides an opportunity for computational prediction of anti-cance...
Zhou, Lin Ao, Luyao Yan, Yunyi Li, Wanting Ye, Anqi Hu, Yahui Fang, Weirong Li, Yunman
Published in
Current drug targets
Some of the current challenges and complications of cancer therapy are chemotherapy- induced peripheral neuropathy (CIPN) and the neuropathic pain that are associated with this condition. Many major chemotherapeutic agents can cause neurotoxicity, significantly modulate the immune system and are always accompanied by various adverse effects. Recent...
Mansuri, Rani Singh, Jagbir Diwan, Anupama
Published in
Current drug targets
Leishmaniasis is one of the six entities on the list of most important diseases of the World Health Organization/Tropical Disease Research (WHO/TDR). After Malaria, it is one of the most prevalent and lethal parasitic diseases. VL is the fatal form of this disease, especially if left untreated. The drugs that are currently available for the treatme...
Santoni, Matteo Heng, Daniel Y C Aurilio, Gaetano Iozzelli, Andrea Servi, Lucilla Fabiani, Andrea Giannini, Massimo Mazzucchelli, Roberta Cimadamore, Alessia Scarpelli, Marina
...
Published in
Current drug targets
Radiotherapy is considered a second life in Renal Cell Carcinoma (RCC) patients, mainly due to the introduction of immune checkpoint inhibitors, such as anti-Programmed-death (PD)-1, alone or in combination with anti-Cytotoxic T-Lymphocyte Antigen (CTLA)-4. Several trials are investigating the efficacy/safety of immune checkpoint inhibitors in sequ...
Szollosi, Doreen Bill, Ashley
Published in
Current drug targets
Influenza is a single-stranded RNA virus that is highly contagious and infects millions of people in the U.S. annually. Due to complications, approximately 959,000 people were hospitalized and another 79,400 people died during the 2017-2018 flu season. While the best methods of prevention continue to be vaccination and hygiene, antiviral treatments...
Li, Min Zhang, Shun Yang, Baoxue
Published in
Current drug targets
Urea Transporters are a family of membrane channel proteins that facilitate the passive transport of urea across the plasma membrane. UTs are divided into two subgroups, UT-A and UT-B. UT-As are primarily located in renal tubule epithelia and UT-Bs are highly expressed in renal descending vasa recta and extrarenal multiple tissues. Various urea tra...
Tazzite, Amal Jouhadi, Hassan Benider, Abdellatif Nadifi, Sellama
Published in
Current drug targets
Triple-negative breast cancer (TNBC) can be distinguished from other breast malignancies by the lack of expression of estrogen receptors (ER), progesterone receptors (PR) as well as human epidermal growth factor receptor 2 (HER2). TNBC is associated with adverse clinical outcomes and high risk of metastasis. Currently, several clinical and translat...
Lengyel, Csongor György Altuna, Sara Cecilia Habeeb, Baker Shalal Trapani, Dario Khan, Shah Zeb
Published in
Current drug targets
In this narrative review, we summarize the role and significance of PI3K-AKTmTOR (PAM) pathway in ovarian and endometrial cancers, providing the most recent and relevant literature on the topic and addressing options for targeting PAM along with future perspectives of drug development. Alterations of the PAM-pathway are common in both endometrial a...
