Published in Current drug targets
Atherothrombosis is the result of direct interaction between atherosclerotic plaque and arterial thrombosis and is the most common type of cardiovascular disease. As a long term progressive disease, atherosclerosis frequently results in an acute atherothrombotic event through plaque rupture and platelet-rich thrombus formation. The pathophysiology ...
Published in Current drug targets
Lack of adequate sleep is a major source of many harmful diseases related to heart, brain, psychological changes, high blood pressure, diabetes, weight gain etc. The 40 to 50 % of the world's population is suffering from poor or inadequate sleep. Insomnia is a sleep disorder in which individual complaint of difficulties in starting/continuing sleep...
Published in Current drug targets
Postmenopausal osteoporosis (PMO) is characterized by low bone mass and structural deterioration of bone tissue with increased risk of fracture in postmenopausal women. It is due to deficiency of estrogen production after the menopause which causes the imbalance in the bone remodeling process where resorption/formation skewed more towards resoption...
Published in Current drug targets
Rheumatoid Arthritis (RA) is a systemic, chronic, autoimmune, inflammatory disorder which affects of the both large and small synovial joints in a symmetric pattern. RA initiates as painful inflammation of the joints leading to stiffness of joint, joint destruction and further worsens the condition causing permanent irreversible damage to the joint...
Published in Current drug targets
Fibroblast growth factor (FGF) family is comprised of 23 highly regulated monomeric proteins which regulate a plethora of developmental and pathophysiological processes, including tissue repair, wound healing, angi-ogenesis, and embryonic development. Binding of FGF to fibroblast growth factor receptor (FGFR), a tyrosine kinase re-ceptor, is facili...
Published in Current drug targets
Cancer is the most ruinous disease globally. Natural products have impressive characteristics, such as excep-tional chemical versatility, chemical and biological properties of macromolecular specificity and less toxicity which make them good leads in finding novel drugs. The phytochemicals not only help to prevent but also treat chronic cancerous c...
Published in Current drug targets
Pulmonary fibrosis (PF) is the most common chronic, progressive interstitial lung disease, mainly occurring in the elderly, with a median survival of 2-4 years after diagnosis. Its high mortality rate attributes to the delay in diagnosis due to its generic symptoms, and more importantly, to the lack of effective treatments. MicroRNAs (miRNAs) are a...
Published in Current drug targets
Surgery is considered as a cornerstone in inflammatory bowel disease (IBD) treatment. In the last years, robotic surgery has seen an increase in adoption rates for both benign and malignant disease. Aim of this work is to review the current applications of robotic surgery in IBD. minimally-invasive techniques have been applied to IBD for more than ...
Published in Current drug targets
Homeostasis of bone is tightly regulated by the balanced activities between bone resorbing activity of osteoclast cells and bone forming ability of osteoblast cells. Multinucleated osteoclasts degrade bone matrix and involve in the dynamic bone remodelling in coordination with osteoblasts. Disruption of this regulatory balance between these cells o...
Published in Current drug targets
Behçet's disease (BD) is presumably an autoinflammatory disease of unknown etiology for which several animal models have been described over the years. Agents and methods used for the development of these models have ranged from the use of transgenic mice, exploring a possible genetic component, to the herpes simplex virus type 1 (HSV-1) pathogen, ...
