Impaired Quality Control of Mitochondria Underlying the Pathogenesis of Alzheimer's Disease.
Published in Current drug targets
Exploring Spike Protein as Potential Target of Novel Coronavirus and to Inhibit the Viability utilizing Natural Agents.
Published in Current drug targets
By the end of 2019 the sudden outbreak of the novel coronavirus disease (COVID-19) has become a global threat. It is called COVID-19 because it was caused by the novel coronavirus (SARS-COV-2) in 2019. A total of 1.9 M deaths and 87.9 M cases have been reported all over the world where 49M cases have recovered so far. Scientists are working hard to...
Review of the biological activity of maslinic acid1.
Published in Current drug targets
Since the discovery of (2α,3β)-2,3-dihydroxyolean-12-en-28-oic acid, also known as maslinic acid, many studies have examined its biological activity, which has been shown to promote health and resist various diseases. This article focuses on previous research on maslinic acid and mainly reviews its reported effects on cardiovascular diseases, neuro...
Recent Advances in Nanotechnology-Based Drug Delivery Approaches for Alzheimer disease.
Published in Current drug targets
One of the most common form of neurodegenerative disorders, Alzheimer's disease poses a great threat to the patients all over the globe with about 5.7 million cases estimated by the Alzheimer's Association Report of 2018. The disorder is a result of β-amyloid deposition in the brain, deteriorating the cognitive ability and learning processes, commo...
Artificial Intelligence, Big data and Machine Learning approaches in Precision Medicine & Drug Discovery.
Published in Current drug targets
Artificial Intelligence revolutionizes the drug development process that can quickly identify potential biologically active compounds from millions of candidate within a short span of time. The present review is an overview based on some applications of Machine Learning based tools such as GOLD, DeepPVP, LIBSVM, etc and the algorithms involved such...
Pivotal Role of the Interaction Between Herbal Medicines and Gut Microbiota on Disease Treatment.
Published in Current drug targets
With the recognition of the important role of gut microbiota in both health and disease progression, attempts to modulate its composition, as well as its co-metabolism with the organism, have attracted special attention. Abundant studies have demonstrated that dysfunction or imbalance of gut microbiota is closely related to disease progression, inc...
PD-L1 Testing for Urothelial Carcinoma: Interchangeability, Reliability and Future Perspectives.
Published in Current drug targets
Five programmed death-1/programmed death-ligand 1 (PD-L1) inhibitors are currently approved for the treatment of locally advanced or metastatic urothelial carcinoma of the bladder and the upper urinary tract. Following the FDA and EMA restrictions of first-line treatment with Atezolizumab and Pembrolizumab in platinum-ineligible patients, immunohis...
Nanocarriers for Photodynamic Therapy Intended to Cutaneous Tumors.
Published in Current drug targets
Photodynamic Therapy (PDT) is a therapeutic modality used for several malignant and premalignant skin disor-ders, including Bowen's disease skin cancers and Superficial Basal Cell Carcinoma (BCC). Several photosensitizers (PSs) have been explored for tumor destruction of skin cancers, after their activation by a light source of appropriate waveleng...
Biomarkers for Early Detection of Colitis-associated Colorectal Cancer - Current Concepts, Future Trends.
Published in Current drug targets
Colitis-associated colorectal cancer (CAC) remains a critical complication of ulcerative colitis (UC) with a mortality of approximately 15%, which makes early CAC diagnosis crucial. The current standard of surveillance, with repetitive colonoscopies and histological testing of biopsied mucosa samples, is burdensome and expensive, and therefore less...
New Paradigms to Help Decisions in Treatment Choice: Head to Head Trial of Biological Therapies in Inflammatory Bowel Di...
...Published in Current drug targets
The increasing armamentarium of drugs for inflammatory bowel disease (IBD) requires a direct comparison of different therapeutic options in order to guide physicians in the choice of the most appropriate treatment for their patients. Head-to-head trials, considered the gold standard in comparative research in IBD, allow to compare different therapi...
