Published in Current drug targets
One of the most common form of neurodegenerative disorders, Alzheimer's disease poses a great threat to the patients all over the globe with about 5.7 million cases estimated by the Alzheimer's Association Report of 2018. The disorder is a result of β-amyloid deposition in the brain, deteriorating the cognitive ability and learning processes, commo...
Published in Current drug targets
Artificial Intelligence revolutionizes the drug development process that can quickly identify potential biologically active compounds from millions of candidate within a short span of time. The present review is an overview based on some applications of Machine Learning based tools such as GOLD, DeepPVP, LIBSVM, etc and the algorithms involved such...
Published in Current drug targets
Photodynamic Therapy (PDT) is a therapeutic modality used for several malignant and premalignant skin disor-ders, including Bowen's disease skin cancers and Superficial Basal Cell Carcinoma (BCC). Several photosensitizers (PSs) have been explored for tumor destruction of skin cancers, after their activation by a light source of appropriate waveleng...
Published in Current drug targets
The increasing armamentarium of drugs for inflammatory bowel disease (IBD) requires a direct comparison of different therapeutic options in order to guide physicians in the choice of the most appropriate treatment for their patients. Head-to-head trials, considered the gold standard in comparative research in IBD, allow to compare different therapi...
Published in Current drug targets
Atherothrombosis is the result of direct interaction between atherosclerotic plaque and arterial thrombosis and is the most common type of cardiovascular disease. As a long term progressive disease, atherosclerosis frequently results in an acute atherothrombotic event through plaque rupture and platelet-rich thrombus formation. The pathophysiology ...
Published in Current drug targets
Lack of adequate sleep is a major source of many harmful diseases related to heart, brain, psychological changes, high blood pressure, diabetes, weight gain etc. The 40 to 50 % of the world's population is suffering from poor or inadequate sleep. Insomnia is a sleep disorder in which individual complaint of difficulties in starting/continuing sleep...
Published in Current drug targets
Postmenopausal osteoporosis (PMO) is characterized by low bone mass and structural deterioration of bone tissue with increased risk of fracture in postmenopausal women. It is due to deficiency of estrogen production after the menopause which causes the imbalance in the bone remodeling process where resorption/formation skewed more towards resoption...
Published in Current drug targets
Rheumatoid Arthritis (RA) is a systemic, chronic, autoimmune, inflammatory disorder which affects of the both large and small synovial joints in a symmetric pattern. RA initiates as painful inflammation of the joints leading to stiffness of joint, joint destruction and further worsens the condition causing permanent irreversible damage to the joint...
Published in Current drug targets
Fibroblast growth factor (FGF) family is comprised of 23 highly regulated monomeric proteins which regulate a plethora of developmental and pathophysiological processes, including tissue repair, wound healing, angi-ogenesis, and embryonic development. Binding of FGF to fibroblast growth factor receptor (FGFR), a tyrosine kinase re-ceptor, is facili...
Published in Current drug targets
Cancer is the most ruinous disease globally. Natural products have impressive characteristics, such as excep-tional chemical versatility, chemical and biological properties of macromolecular specificity and less toxicity which make them good leads in finding novel drugs. The phytochemicals not only help to prevent but also treat chronic cancerous c...
