Xu, Yingwei Yang, Lianzhi Wang, Yaping Zhu, Zhuoying Yan, Jizhou Qin, Si Chen, Lanming
Published in
Current genetics
Vibrio parahaemolyticus is a waterborne pathogen that can cause acute gastroenteritis, wound infection, and septicemia in humans. The molecular basis of its pathogenicity is not yet fully understood. Phages are found most abundantly in aquatic environments and play a critical role in horizontal gene transfer. Nevertheless, current literature on bio...
Gasparayan, Hovik Caridi, Chris Julius, Jeff Feng, Wenyi Bachant, Jeff Nugent, Constance I.
Published in
Current Genetics
Treating yeast cells with the replication inhibitor hydroxyurea activates the S phase checkpoint kinase Rad53, eliciting responses that block DNA replication origin firing, stabilize replication forks, and prevent premature extension of the mitotic spindle. We previously found overproduction of Stn1, a subunit of the telomere-binding Cdc13–Stn1–Ten...
Bachant, Jeff Hoffman, Elizabeth A. Caridi, Chris Nugent, Constance I. Feng, Wenyi
Published in
Current Genetics
Dbf4 is the cyclin-like subunit for the Dbf4-dependent protein kinase (DDK), required for activating the replicative helicase at DNA replication origin that fire during S phase. Dbf4 also functions as an adaptor, targeting the DDK to different groups of origins and substrates. Here we report a genome-wide analysis of origin firing in a budding yeas...
Deshpande, Neha Jordan, Rachel Henderson Pozzi, Michelle Bryk, Mary
Published in
Current Genetics
Mono-methylation of the fourth lysine on the N-terminal tail of histone H3 was found to support the induction of RNA polymerase II transcription in S. cerevisiae during nutrient stress. In S. cerevisiae , the mono-, di- and tri-methylation of lysine 4 on histone H3 (H3K4) is catalyzed by the protein methyltransferase, Set1. The three distinct methy...
Gallardo, Paola Salas-Pino, Silvia Daga, Rafael R
Published in
Current genetics
Temperature fluctuation is one of the most frequent threats to which organisms are exposed in nature. The activation of gene expression programs that trigger the transcription of heat stress-protective genes is the main cellular response to resist high temperatures. In addition, reversible accumulation and compartmentalization of thermosensitive pr...
Papp, László Attila Ács-Szabó, Lajos Batta, Gyula Miklós, Ida
Published in
Current genetics
Fungal pathogens, from phytopathogenic fungus to human pathogens, are able to alternate between the yeast-like form and filamentous forms. This morphological transition (dimorphism) is in close connection with their pathogenic lifestyles and with their responses to changing environmental conditions. The mechanisms governing these morphogenetic conv...
O’Brien, Michael J. Ansari, Athar
Published in
Current Genetics
The role of general transcription factor TFIIB in transcription extends well beyond its evolutionarily conserved function in initiation. Chromatin localization studies demonstrating binding of TFIIB to both the 5’ and 3’ ends of genes in a diverse set of eukaryotes strongly suggested a rather unexpected role of the factor in termination. TFIIB inde...
Veetilvalappil, Vimal Venu Aranjani, Jesil Mathew Mahammad, Fayaz Shaik Joseph, Alex
Published in
Current Genetics
Magic spot synthetases are emerging targets to overcome persistence caused by stringent response. The ‘stringent response’ is a bacterial stress survival mechanism, which results in the accumulation of alarmones (also called Magic spots) leading to the formation of dormant persister cells. These ‘sleeper cells’ evade antibiotic treatment and could ...
Frimodt-Møller, Jakob Campion, Christopher Nielsen, Peter E. Løbner-Olesen, Anders
Published in
Current Genetics
The increase in multidrug-resistant pathogenic bacteria has become a problem worldwide. Currently there is a strong focus on the development of novel antimicrobials, including antimicrobial peptides (AMP) and antimicrobial antisense agents. While the majority of AMP have membrane activity and kill bacteria through membrane disruption, non-lytic AMP...
Lettow, Julia Aref, Rasha Schüller, Hans-Joachim
Published in
Current Genetics
Under non-inducing conditions (absence of galactose), yeast structural genes of the GAL regulon are repressed by Gal80, preventing interaction of Gal4 bound to UASGAL promoter motifs with general factors of the transcriptional machinery. In this work, we show that Gal80 is also able to interact with histone deacetylase-recruiting corepressor protei...
