Badia, E Duchesne, M J Astruc, M Fuentes, M Gagne, D Nicolas, J C Pons, M
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Comptes rendus des seances de la Societe de biologie et de ses filiales
The effects of a prolonged antiestrogen treatment on two estrogen-dependent responses and an AP-1 response were studied on two cell lines derived from MCF-7 cells. 1) Hydroxytamoxifen specifically provoked an irreversible inactivation of a chimeric estrogen-dependent gene expression in less than 30 days. This process was estrogen receptor mediated ...
Lagarde, M
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Comptes rendus des seances de la Societe de biologie et de ses filiales
Eicosanoids are oxygenated derivatives from 20-carbon polyunsaturated fatty acids. Among these, arachidonic acid is the reference precursor from which most metabolic pathways have been described. These pathways correspond to the biosynthesis of prostanoids with a recent revival interest after the discovery of an inducible form of prostaglandin H sy...
Gambert, P
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Comptes rendus des seances de la Societe de biologie et de ses filiales
Human lipoproteins after their intestinal or hepatic synthesis undergo within vascular compartment important remodeling through the agency of endothelial lipases, Lecithin: Cholesterol Acyl Transferase and lipid transfer proteins, Cholesteryl Ester Transfer Protein (CETP) and Phospholipid Transfer Protein (PLTP). Following CETP and PLTP characteris...
Edeas, M Khalfoun, Y Lazizi, Y Vergnes, L Labidalle, S Postaire, E Lindenbaum, A
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Comptes rendus des seances de la Societe de biologie et de ses filiales
A large body of evidence indicates that AIDS may be the consequence of a virus-induced antioxidant deficiency and implicates reactive oxygen species (ROS) in the pathogenesis of HIV infection. The high level of antigenic acid and cytokines activities in AIDS results in the production of superoxides (O2-), hydrogen peroxide (H202) and hydroxyl radic...
Schaeverbeke, J
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Comptes rendus des seances de la Societe de biologie et de ses filiales
Until the last decade, kidney aging was considered to be the result of progressive loss of nephrons associated with development of glomerulosclerosis and thus decrease in glomerular filtration rate, and finally renal deficiency. However this nephropathy can also result of environmental (such as husbandry conditions, diet ...) and genetical factors....
Demerlé-Pallardy, C Chabrier, P E
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Comptes rendus des seances de la Societe de biologie et de ses filiales
In the central nervous system, several cellular types are able to produce nitric oxide (NO). In particular in neuronal cells, the excitatory amino-acid receptor activation induces NO synthesis and release. Since excessive activation of these receptors is responsible of neuronal death in excitotoxicity or cerebral ischemia, the hypothesis of a NO ro...
Raes, M Renard, P Remacle, J
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Comptes rendus des seances de la Societe de biologie et de ses filiales
Cytokines such as IL-1 or TNF-alpha induce a specific cellular responses through the activation of a transcriptional factor, NF kappa B. This activation requires the phosphorylation of an inhibitory subunit, I kappa B, which relies upon an intracellular production of reactive oxygen intermediates. Peroxides, but also the increase of the GSSG/GSH ra...
Maggi, M F Cristol, J P Guérin, M C Descomps, B Torreilles, J
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Comptes rendus des seances de la Societe de biologie et de ses filiales
Superoxide (O2-) and nitric oxide (.NO) are free radicals which are known to react together leading to peroxynitrite anions that can decompose to form nitrogen dioxide (NO2) and hydroxyl radical (OH degrees). .NO has been reported to have a dual effect on LDL oxidation (pro or antioxidant). In the present study we have investigated in vitro the act...
Torreilles, J Guérin, M C
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Comptes rendus des seances de la Societe de biologie et de ses filiales
Ten years ago, the term "oxidative stress" (sigma -O2) was created to define oxidative damage inflicted to the organism. This definition brings together processes involving reactive oxygen species production and action such as free radical production during univalent reduction of oxygen within mitochondria, activation of NADPH-dependent oxidase sys...
Souchard, J P Limasset, B Michel, F Crastes de Paulet, A Labidalle, S Nepveu, F
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Comptes rendus des seances de la Societe de biologie et de ses filiales
Guaiacol moiety has been found in antiinflammatory compounds present in traditional african or chinese medicine. As the activity of these products could be due to reactions with the reactive oxygen species (ROS) or enzymes involved in the inflammatory reaction, a comparative study has been done between biological and physico-chemical investigations...
