Brière, J Kiladjian, J J Peynaud-Debayle, E
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Comptes rendus des seances de la Societe de biologie et de ses filiales
Megakaryocyte proliferation in bone marrow is a feature common to the three Philadelphia negative chromosome myeloproliferative disorders (MPD)--essential thrombocythemia (ET), polycythemia vera, and myelofibrosis with splenic myeloid metaplasia--and chronic myelocytic leukemia. Enlarged megakaryocytes, clustering in close neighbouring with multilo...
Attié, T Salomon, R Amiel, J Edery, P Pelet, A Nihoul-Fékété, C Munnich, A Lyonnet, S
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Comptes rendus des seances de la Societe de biologie et de ses filiales
Hirschsprung disease (HD) is one of the commonest gastro-intestinal malformations, as it affects one child out of 5,000 births. It classically induces severe neonatal intestinal obstruction requiring surgical treatment which currently ensures a favourable prognosis for most of the affected children. Although the great majority of cases are sporadic...
Bellucci, S Han, Z C Caen, J P
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Comptes rendus des seances de la Societe de biologie et de ses filiales
Megakaryocytopoiesis concerns the commitment of hematopoietic stem cells towards the megakaryocyte lineage, the proliferation and maturation of megakaryocyte progenitors, leading to platelet formation. Normal megakaryocytopoiesis requires an equilibrium between positive and negative regulators. Thrombopoietin, recently cloned, is the main growth fa...
Barrier, L Tallineau, C Fauconneau, B Piriou, A
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Comptes rendus des seances de la Societe de biologie et de ses filiales
The aim of this study was to determine: 1) the source of Thiobarbituric Reactive Substances (TBARS) spontaneously produced during rat brain homogenate incubation; 2) the cellular components involved; 3) the reason why brain and liver homogenates did not have the same behaviour. Measurements of TBARS, Polyunsaturated Fatty Acids (PUFAs), aldehydes c...
Sultan, C Lumbroso, S Poujol, N Boudon, C Georget, V Térouanne, B Belon, C Lobaccaro, J M
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Comptes rendus des seances de la Societe de biologie et de ses filiales
The various processes involved in sexual differentiation have been considerably clarified over the last few years through advances in biochemistry and molecular genetics. The cloning of the gene responsible for testicular determination SRY, of the anti-Müllerian hormone and anti-Müllerian hormone receptor genes, of the several steroidogenic enzymes...
Léger, C L Kadri-Hassani, N
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Comptes rendus des seances de la Societe de biologie et de ses filiales
It is largely admitted nowadays that the early stage of the atherosclerotic lesion involves formation of oxidized (and minimally oxidized) low-density lipoprotein. Their properties are briefly reviewed. It is recalled that a lipolytic process also takes place both at the lumenal surface and in the subendothelial space of the vessels implying lipopr...
Appay, M D Heudes, D Xu, Y C Lemoine, R Hinglais, N Michel, J B Bariéty, J
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Comptes rendus des seances de la Societe de biologie et de ses filiales
In the two-kidney one-clip hypertensive Goldblatt model of nephrosclerosis, the aim of this study was to detect, during the first twenty-eight days of high blood pressure, interstitial and periarterial (interlobular arterial and arteriolar) kidney changes. Morphometric analysis for type I collagen, in situ hybridization for type I and IV collagen m...
Fournier, J Copin, E Chouchane, S Dzwigaj, S Guignard, J
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Comptes rendus des seances de la Societe de biologie et de ses filiales
Oxidizing activity study of inorganic compounds is based on a mechanistic approach. This approach implies research of the capacity of these materials, after interaction with molecular oxygen, to generate activated oxygen species (AOS) in aqueous medium. These electrophilic species are able to participate in oxidative stress processes and some AOS d...
Henry, Y Guissani, A
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Comptes rendus des seances de la Societe de biologie et de ses filiales
In this review we recall the main physical properties of nitric oxide. The irreversible reactions of NO with O2 and O2.-, which yield strongly oxydant and nitrosating, and therefore toxic, species, are described in kinetic terms. Nearly all metalloproteins are potential targets for NO, often detectable by EPR spectroscopy. The case of hemoglobin in...
Hoang Hung, T Gerber, G B Léonard, E D Crutzen-Fayt, M C Richard, F Léonard, A
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Comptes rendus des seances de la Societe de biologie et de ses filiales
The dose effect relationship after homogeneous irradiation and the effect on the Poisson distribution of adding non-irradiated blood and thereby simulating non homogenous accidental exposure were studied for dicentric aberrations and micronuclei in lymphocytes exposed in vitro to 60Co gamma irradiation. The dose effect relationship for both paramet...