Decreased Glasgow Coma Scale score in medical patients as an indicator for intubation in the Emergency Department: Why a...
Published in Clinics (Sao Paulo, Brazil)
Safety and effectiveness of mycophenolate mofetil associated with tacrolimus for liver transplantation immunosuppression...
...Published in Clinics (Sao Paulo, Brazil)
A combination of immunosuppressants may improve outcomes due to the synergistic effect of their different action mechanisms. Currently, there is no consensus regarding the best immunosuppressive protocol after liver transplantation. This review aimed to evaluate the effectiveness and safety of tacrolimus associated with mycophenolate mofetil (MMF) ...
Endoscopy infection control strategy during the COVID-19 pandemic: experience from a tertiary cancer center in Brazil.
...Published in Clinics (Sao Paulo, Brazil)
Strategic planning for coronavirus disease (COVID-19) care has dominated the agenda of medical services, which have been further restricted by the need for minimizing viral transmission. Risk is particularly relevant in relation to endoscopy procedures. This study aimed to describe a contingency plan for a tertiary academic cancer center, define a ...
Signs of impending rupture in abdominal aortic and iliac artery aneurysms by computed tomography: Outcomes in 41 patient...
Published in Clinics (Sao Paulo, Brazil)
This study aimed to determine the prevalence of signs of impending rupture (SIR) in asymptomatic patients with abdominal aortic and iliac artery aneurysms, and to evaluate whether these signs were associated with rupture in asymptomatic patients. This was a retrospective study of patients with abdominal aortic and iliac artery aneurysms identified ...
miR-139-5p protects septic mice with acute lung injury by inhibiting Toll-like receptor 4/Myeloid differentiation factor...
Published in Clinics (Sao Paulo, Brazil)
To investigate the role of miR-139-5p and the TLR4/MyD88/NF-κB signaling pathway in acute lung injury in septic mice. A total of 140 healthy male SPF C57BL/6 mice were divided into seven groups, i.e., Normal, Control, NC, miR-139-5p mimic, miR-139-5p inhibitor, TAK-242, and miR-139-5p inhibitor+TAK-242 groups. The levels of miR-139-5p, proteins rel...
Acellular dermal matrix in skin wound healing in rabbits - histological and histomorphometric analyses.
Published in Clinics (Sao Paulo, Brazil)
To analyze the histology and histomorphometry of healing associated with acellular dermal matrix in skin wounds in rabbits. Twelve male rabbits were divided into two groups: the control group (CG) and the matrix group (MG). Three skin wounds with a total area of 20 × 20 mm were created on the dorsal region of each animal. Photographic records of th...
Azeliragon ameliorates Alzheimer's disease via the Janus tyrosine kinase and signal transducer and activator of transcri...
Published in Clinics (Sao Paulo, Brazil)
TTP488, an antagonist of the receptor for advanced glycation end-products, was evaluated as a potential treatment for patients with mild-to-moderate Alzheimer's disease (AD). However, the mechanism underlying the protective action of TTP488 against AD has not yet been fully explored. Healthy male rats were exposed to aberrant amyloid β (Aβ) 1-42. L...
Reopening borders: protocols for resuming travel during the COVID-19 pandemic.
Published in Clinics (Sao Paulo, Brazil)
Fatty Pancreas: Disease or Finding?
Published in Clinics
Despite a growing number of investigative studies on pancreatic fat deposition, there remains no clear indication regarding the clinical relevance of fat infiltration in the pancreas, also called fatty pancreas (FP). An individual’s body weight is correlated with their pancreatic weight. Moreover, lipid infiltration causes disorders that compromise...
Arterial stiffness in type 2 diabetes: determinants and indication of a discriminative value
Published in Clinics
OBJECTIVES: To identify the clinical discriminative value and determinants of arterial stiffness in individuals with type 2 diabetes mellitus (T2DM). METHODS: This prospective cohort study included 51 individuals (53.57±9.35 years) diagnosed with T2DM (stage glucose≥126 mg/dL; diagnostic time: 87.4±69.8 months). All participants underwent an initia...
