The measurement of leukotrienes in human fluids.
Published in Clinical reviews in allergy & immunology
Antileukotrienes and laboratory models of asthma.
Published in Clinical reviews in allergy & immunology
Biochemistry and physiology of the leukotrienes.
Published in Clinical reviews in allergy & immunology
Based on the studies that have used human subjects and materials, and a much larger body of data from animal and in vitro experiments, one can conclude that the LTs are potent bronchoconstrictors in normal and asthmatic subjects. A major part of their action is mediated directly via the cysLT-1 receptor on airway smooth muscle. There is also eviden...
Anaphylaxis and food allergy.
Published in Clinical reviews in allergy & immunology
Allergic emergencies in the emergency room.
Published in Clinical reviews in allergy & immunology
Mutations in the human 5-lipoxygenase gene.
...Published in Clinical reviews in allergy & immunology
Our data demonstrate the presence of a naturally occurring family of alleles in the core promoter of the 5-LO gene, which is characterized by the deletion or addition of consensus Sp1 (-GGGCGG) and Egr-1 (-GCGGGGGCG-) binding motifs. Each of the variant alleles can bind Sp1 and Egr-1 protein, as indicated by EMSA and supershift analysis with nuclea...
Regulation and metabolism of arachidonic acid.
Published in Clinical reviews in allergy & immunology
The metabolism of AA reflects a carefully balanced series of biochemical pathways. The level of free arachidonate in a cells is controlled by de novo synthesis, dietary uptake, and transcellular metabolism. Lysophospholipids are key controlling substrates for a variety of acyl transferase and transacylase reactions, whose combined effect is to remo...
Allergic emergencies encountered by the dermatologist. Severe cutaneous adverse drug reactions.
Published in Clinical reviews in allergy & immunology
The role of food allergy and other allergic disease in atopic dermatitis.
Published in Clinical reviews in allergy & immunology
Severe acute asthma.
Published in Clinical reviews in allergy & immunology
