Zhao, Xuetong Sui, Yang Ruan, Xiuyan Wang, Xinyue He, Kunlun Dong, Wei Qu, Hongzhu Fang, Xiangdong
Published in
Clinical Epigenetics
BackgroundHeart failure with preserved ejection fraction (HFpEF), affected collectively by genetic and environmental factors, is the common subtype of chronic heart failure. Although the available risk assessment methods for HFpEF have achieved some progress, they were based on clinical or genetic features alone. Here, we have developed a deep lear...
Ammous, Farah Zhao, Wei Lin, Lisha Ratliff, Scott M. Mosley, Thomas H. Bielak, Lawrence F. Zhou, Xiang Peyser, Patricia A. Kardia, Sharon L. R. Smith, Jennifer A.
...
Published in
Clinical Epigenetics
BackgroundDNA methylation, an epigenetic mechanism modulated by lifestyle and environmental factors, may be an important biomarker of complex diseases including cardiovascular diseases (CVD) and subclinical atherosclerosis.MethodsDNA methylation in peripheral blood samples from 391 African-Americans from the Genetic Epidemiology Network of Arteriop...
Herrera-Luis, Esther Li, Annie Mak, Angel C. Y. Perez-Garcia, Javier Elhawary, Jennifer R. Oh, Sam S. Hu, Donglei Eng, Celeste Keys, Kevin L. Huntsman, Scott
...
Published in
Clinical Epigenetics
IntroductionDNA methylation studies have associated methylation levels at different CpG sites or genomic regions with lung function. Moreover, genetic ancestry has been associated with lung function in Latinos. However, no epigenome-wide association study (EWAS) of lung function has been performed in this population. Here, we aimed to identify DNA ...
Pantelaiou-Prokaki, Garyfallia Mieczkowska, Iga Schmidt, Geske E. Fritzsche, Sonja Prokakis, Evangelos Gallwas, Julia Wegwitz, Florian
Published in
Clinical Epigenetics
BackgroundBasal-like breast cancer (BLBC) is one of the most aggressive malignant diseases in women with an increased metastatic behavior and poor prognosis compared to other molecular subtypes of breast cancer. Resistance to chemotherapy is the main cause of treatment failure in BLBC. Therefore, novel therapeutic strategies counteracting the gain ...
Titanji, Boghuma K. Gwinn, Marta Marconi, Vincent C. Sun, Yan V.
Published in
Clinical Epigenetics
Despite significant advances in the treatment and care of people with HIV (PWH), several challenges remain in our understanding of disease pathogenesis to improve patient care. HIV infection can modify the host epigenome and as such can impact disease progression, as well as the molecular processes driving non-AIDS comorbidities in PWH. Epigenetic ...
Antoun, Elie Issarapu, Prachand di Gravio, Chiara Shrestha, Smeeta Betts, Modupeh Saffari, Ayden Sahariah, Sirazul A. Sankareswaran, Alagu Arumalla, Manisha Prentice, Andrew M.
...
Published in
Clinical Epigenetics
BackgroundThe prevalence of cardiometabolic disease (CMD) is rising globally, with environmentally induced epigenetic changes suggested to play a role. Few studies have investigated epigenetic associations with CMD risk factors in children from low- and middle-income countries. We sought to identify associations between DNA methylation (DNAm) and C...
Müller, Melanie R. Burmeister, Aaron Skowron, Margaretha A. Stephan, Alexa Bremmer, Felix Wakileh, Gamal A. Petzsch, Patrick Köhrer, Karl Albers, Peter Nettersheim, Daniel
...
Published in
Clinical Epigenetics
BackgroundType II germ cell tumors (GCT) are the most common solid cancers in males of age 15 to 35 years. Treatment of these tumors includes cisplatin-based therapy achieving high cure rates, but also leading to late toxicities. As mainly young men are suffering from GCTs, late toxicities play a major role regarding life expectancy, and the develo...
Kuang, Chaoyuan Park, Yongseok Augustin, Ryan C. Lin, Yan Hartman, Douglas J. Seigh, Lindsey Pai, Reetesh K. Sun, Weijing Bahary, Nathan Ohr, James
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Published in
Clinical Epigenetics
BackgroundDNA mismatch repair proficient (pMMR) metastatic colorectal cancer (mCRC) is not responsive to pembrolizumab monotherapy. DNA methyltransferase inhibitors can promote antitumor immune responses. This clinical trial investigated whether concurrent treatment with azacitidine enhances the antitumor activity of pembrolizumab in mCRC.MethodsWe...
Loaeza-Loaeza, Jaqueline Illades-Aguiar, Berenice del Moral-Hernández, Oscar Castro-Coronel, Yaneth Leyva-Vázquez, Marco A. Dircio-Maldonado, Roberto Ortiz-Ortiz, Julio Hernández-Sotelo, Daniel
Published in
Clinical Epigenetics
BackgroundHigh-risk human papillomavirus (HR-HPV) infection is the main cause of cervical cancer, but additional alterations are necessary for its development. Abnormal DNA methylation has an important role in the origin and dissemination of cervical cancer and other human tumors. In this work, we analyzed the methylation of eight genes (AJAP1, CDH...
Zhang, Jiewen Shang, Junkui Wang, Fengyu Huo, Xuejing Sun, Ruihua Ren, Zhixia Wang, Wan Yang, Miaomiao Li, Gai Gao, Dandan
...
Published in
Clinical Epigenetics
BackgroundCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a typical neurodegenerative disease associated with mitochondrial dysfunction. Methylation of the D-loop region and mitochondrial DNA copy number (mtDNAcn) play a critical role in the maintenance of mitochondrial function. However, the ...
