Wang, Wan-Ru Chen, Nai-Tzu Hsu, Nai-Yun Kuo, I-Ying Chang, Hsin-Wen Wang, Jiu-Yao Su, Huey-Jen
Published in
Clinical Epigenetics
BackgroundDysregulation of thymic stromal lymphopoietin (TSLP) expressions is linked to asthma and allergic disease. Exposure to phthalate esters, a widely used plasticizer, is associated with respiratory and allergic morbidity. Dibutyl phthalate (DBP) causes TSLP upregulation in the skin. In addition, phthalate exposure is associated with changes ...
Palou-Márquez, Guillermo Subirana, Isaac Nonell, Lara Fernández-Sanlés, Alba Elosua, Roberto
Published in
Clinical Epigenetics
BackgroundThe integration of different layers of omics information is an opportunity to tackle the complexity of cardiovascular diseases (CVD) and to identify new predictive biomarkers and potential therapeutic targets. Our aim was to integrate DNA methylation and gene expression data in an effort to identify biomarkers related to cardiovascular di...
Miyake, Kunio Miyashita, Chihiro Ikeda-Araki, Atsuko Miura, Ryu Itoh, Sachiko Yamazaki, Keiko Kobayashi, Sumitaka Masuda, Hideyuki Ooka, Tadao Yamagata, Zentaro
...
Published in
Clinical Epigenetics
BackgroundPrenatal smoking exposure has been associated with childhood attention-deficit/hyperactivity disorder (ADHD). However, the mechanism underlying this relationship remains unclear. We assessed whether DNA methylation differences may mediate the association between prenatal smoking exposure and ADHD symptoms at the age of 6 years.ResultsWe s...
Amatori, Stefano Tavolaro, Simona Gambardella, Stefano Fanelli, Mirco
Published in
Clinical Epigenetics
BackgroundThe oncogenic role of histone mutations is one of the most relevant discovery in cancer epigenetics. Recurrent mutations targeting histone genes have been described in pediatric brain tumors, chondroblastoma, giant cell tumor of bone and other tumor types. The demonstration that mutant histones can be oncogenic and drive the tumorigenesis...
Masunaga, Yohei Kagami, Masayo Kato, Fumiko Usui, Takeshi Yonemoto, Takako Mishima, Kazuo Fukami, Maki Aoto, Kazushi Saitsu, Hirotomo Ogata, Tsutomu
...
Published in
Clinical Epigenetics
BackgroundParthenogenetic mosaicism is an extremely rare condition identified only in five subjects to date. The previous studies indicate that this condition is mediated by parthenogenetic activation and is free from a specific phenotype ascribed to unmaking of a maternally inherited recessive variant in the parthenogenetic cell lineage.ResultsWe ...
Ramadan, Wafaa S. Talaat, Iman M. Hachim, Mahmood Y. Lischka, Annette Gemoll, Timo El-Awady, Raafat
Published in
Clinical Epigenetics
BackgroundThe development of new biomarkers with diagnostic, prognostic and therapeutic prominence will greatly enhance the management of breast cancer (BC). Several reports suggest the involvement of the histone acetyltransferases CREB-binding protein (CBP) and general control non-depressible 5 (GCN5) in tumor formation; however, their clinical si...
Lobo, João Constâncio, Vera Leite-Silva, Pedro Guimarães, Rita Cantante, Mariana Braga, Isaac Maurício, Joaquina Looijenga, Leendert H. J. Henrique, Rui Jerónimo, Carmen
...
Published in
Clinical Epigenetics
Testicular germ cell tumors (TGCTs) are among the most common solid malignancies in young-adult men, and currently most mortality is due to metastatic disease and emergence of resistance to cisplatin. There is some evidence that increased methylation is one mechanism behind this resistance, stemming from individual studies, but approaches based on ...
Russell, Holly Kedzierska, Katarzyna Buchanan, Daniel D. Thomas, Rachael Tham, Emma Mints, Miriam Keränen, Anne Giles, Graham G. Southey, Melissa C. Milne, Roger L.
...
Published in
Clinical Epigenetics
An amendment to this paper has been published and can be accessed via the original article.
Pfeiffer, J. R. Bustamante, Angela C. Kim, Grace S. Armstrong, Don Knodt, Annchen R. Koenen, Karestan C. Hariri, Ahmad R. Uddin, Monica
Published in
Clinical Epigenetics
BackgroundPoor family emotional health (FEH) during childhood is prevalent and impactful, and likely confers similar neurodevelopmental risks as other adverse social environments. Pointed FEH study efforts are underdeveloped, and the mechanisms by which poor FEH are biologically embedded are unclear. The current exploratory study examined whether v...
Gombert, Sara Rhein, Mathias Winterpacht, Andreas Münster, Tino Hillemacher, Thomas Leffler, Andreas Frieling, Helge
Published in
Clinical Epigenetics
An amendment to this paper has been published and can be accessed via the original article.