Garciaz, Sylvain N’guyen Dasi, Lia Finetti, Pascal Chevalier, Christine Vernerey, Julien Poplineau, Mathilde Platet, Nadine Audebert, Stéphane Pophillat, Matthieu Camoin, Luc
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Published in
Clinical Epigenetics
BackgroundThe epigenetic machinery is frequently altered in acute myeloid leukemia. Focusing on cytogenetically normal (CN) AML, we previously described an abnormal H3K27me3 enrichment covering 70 kb on the HIST1 cluster (6.p22) in CN-AML patient blasts. Here, we further investigate the molecular, functional, and prognosis significance of this epig...
Desjobert, Cécile Carrier, Arnaud Delmas, Audrey Marzese, Diego M. Daunay, Antoine Busato, Florence Pillon, Arnaud Tost, Jörg Riond, Joëlle Favre, Gilles
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Published in
Clinical Epigenetics
BackgroundEfficient treatments against metastatic melanoma dissemination are still lacking. Here, we report that low-cytotoxic concentrations of 5-aza-2′-deoxycytidine, a DNA demethylating agent, prevent in vitro 3D invasiveness of metastatic melanoma cells and reduce lung metastasis formation in vivo.ResultsWe unravelled that this beneficial effec...
Johansson, Annelie Palli, Domenico Masala, Giovanna Grioni, Sara Agnoli, Claudia Tumino, Rosario Giurdanella, Maria Concetta Fasanelli, Francesca Sacerdote, Carlotta Panico, Salvatore
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Published in
Clinical Epigenetics
BackgroundIt is well established that estrogens and other hormonal factors influence breast cancer susceptibility. We hypothesized that a woman’s total lifetime estrogen exposure accumulates changes in DNA methylation, detectable in the blood, which could be used in risk assessment for breast cancer.MethodsAn estimated lifetime estrogen exposure (E...
Nitschkowski, Dörte Marwitz, Sebastian Kotanidou, Sousana A. Reck, Martin Kugler, Christian Rabe, Klaus F. Ammerpohl, Ole Goldmann, Torsten
Published in
Clinical Epigenetics
Recently, it was shown that the epigenetic age of non-small cell lung cancer (NSCLC) tissues is different from the chronological age of patients. Here, we demonstrate that Regucalcin and Survivin, molecules which are known to be involved in the process of aging and overcoming aging, are epigenetically modified in NSCLC tissues compared to correspon...
Krzyzewska, I. M. Maas, S. M. Henneman, P. Lip, K. v. d. Venema, A. Baranano, K. Chassevent, A. Aref-Eshghi, E. van Essen, A. J. Fukuda, T.
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Published in
Clinical Epigenetics
SETD1B is a component of a histone methyltransferase complex that specifically methylates Lys-4 of histone H3 (H3K4) and is responsible for the epigenetic control of chromatin structure and gene expression. De novo microdeletions encompassing this gene as well as de novo missense mutations were previously linked to syndromic intellectual disability...
Snider, Hilary Villavarajan, Brithica Peng, Yingwei Shepherd, Lois E. Robinson, Andrew C. Mueller, Christopher R.
Published in
Clinical Epigenetics
BackgroundThe glucocorticoid receptor (NR3C1, GR) is frequently downregulated in breast tumors, and evidence suggests it acts as a tumor suppressor in estrogen receptor-positive (ER+) breast cancer. We previously found that methylation of the GR promoter CpG island represses gene expression and occurs in ER+ breast tumors. In this study, the progno...
Fang, Wen-Liang Chen, Ming-Huang Huang, Kuo-Hung Chang, Shih-Ching Lin, Chien-Hsing Chao, Yee Lo, Su-Shun Li, Anna Fen-Yau Wu, Chew-Wun Shyr, Yi-Ming
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Published in
Clinical Epigenetics
BackgroundAberrant DNA methylation is involved in gastric carcinogenesis and may serve as a useful biomarker in the diagnosis and detection of gastric cancer (GC) recurrence.ResultsA total of 157 patients who received surgery for GC were enrolled in the present study. A genome-wide methylation analysis was performed in tumor and adjacent normal tis...
Tian, Hua Yan, Li Xiao-fei, Li Hai-yan, Sun Juan, Chen Shan, Kang
Published in
Clinical Epigenetics
PurposeOne major reason of the high mortality of epithelial ovarian cancer (EOC) is due to platinum-based chemotherapy resistance. Aberrant DNA methylation may be a potential mechanism underlying the development of platinum resistance in EOC. The purpose of this study is to discover potential aberrant DNA methylation that contributes to drug resist...
Fiano, Valentina Zugna, Daniela Grasso, Chiara Trevisan, Morena Delsedime, Luisa Molinaro, Luca Cassoni, Paola Papotti, Mauro Merletti, Franco Akre, Olof
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Published in
Clinical Epigenetics
BackgroundMen often undergo repeat prostate biopsies because of suspicion of missed cancer. We assessed if (i) methylation of selected genes in prostate tissue vary with aging and (ii) methylation alterations in repeat biopsies predict missed prostate cancer.MethodsWe conducted a case-control study among men who underwent at least two negative pros...
Locken-Castilla, Alejandra Pacheco-Pantoja, Elda Leonor Rodríguez-Brito, Fátima May-Kim, Sherlin López-Rivas, Victor Ceballos-Cruz, Angel
Published in
Clinical Epigenetics
BackgroundIt is widely accepted that genomic instability is associated with several mechanisms involving oxidative stress, which can increase the rate of DNA breaks. Such factors include smoking, impairments in body composition, an unhealthy lifestyle, and a hereditary history of cancer. The aim was to evaluate the degree of association of genomic ...
