Zhu, Y. Xu, Y. Chen, D. Zhang, C. Rui, W. Zhao, J. Zhu, Q. Wu, Y. Shen, Z. Wang, W.
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Published in
Clinical and Translational Oncology
ObjectiveThe aim of this study was to determine the correlation between human adrenocortical carcinoma and the proteins involved in tumor angiogenesis, and to evaluate the angiogenic status of adrenocortical carcinoma.MethodsThe expression of signal transducer and activator of transcription 3 and insulin-like growth factor 2 as well as microvessel ...
Li, C. Sun, B.-Q. Gai, X.-D.
Published in
Clinical and Translational Oncology
Multidrug resistance (MDR) is a major obstacle to successful cancer chemotherapy. One of the main underlying mechanisms of this resistance is the over-expression of P-glycoprotein (P-gp), an ATP-dependent transmembrane transporter protein encoded by the MDR1 gene. P-gp might transport anti-cancer drugs out of cancer cells and decrease effective int...
Shi, Z.-Z. Jiang, Y.-Y. Hao, J.-J. Zhang, Y. Zhang, T.-T. Shang, L. Liu, S.-G. Shi, F. Wang, M.-R.
Published in
Clinical and Translational Oncology
BackgroundGenomic aberration is a common feature of human cancers and also is one of the basic mechanisms that lead to overexpression of oncogenes and underexpression of tumor suppressor genes. Our study aims to identify frequent genomic changes and candidate copy number driving genes in esophageal squamous cell carcinoma (ESCC).MethodsWe used arra...
Ren, J. Xu, S. Guo, D. Zhang, J. Liu, S.
Published in
Clinical and Translational Oncology
ObjectiveThe study was to evaluate the association of expression level of α5β1-integrin with clinicopathologic features and prognosis in gastric cancer (GC).MethodsThe expression of α5β1-integrin in normal gastric mucosa and GC tissue was detected with immunohistochemistry. The level of α5 and β1 mRNA in GC tissues and non-neoplastic tissues was ev...
Guo, X.-P. Wang, Y. Zhao, H. Song, S.-D. Zhou, J. Han, Y.
Published in
Clinical and Translational Oncology
ObjectivesTo investigate the relationship of the MTHFR polymorphisms (C677T) and the risk of CRC by meta-analysis.MethodsRelevant literatures concerning the association between the MTHFR C677T polymorphism and the risk of CRC were searched using the electronic database PubMed, EMBASE, Cochrane and China National Knowledge Infrastructure (CNKI). Odd...
Cai, J. Chen, S. Zhang, W. Wei, Y. Lu, J. Xing, J. Dong, Y.
Published in
Clinical and Translational Oncology
Background5-Fluorouracil (5-Fu) is a commonly used chemotherapeutic agent in clinical care of breast cancer patients. However, the mechanism of how the 5-Fu works is complex and still largely unknown.ObjectiveThe objective of this study was to understand the mechanism further and explore the new targets of 5-Fu.MethodsThe differentially expressed p...
Juan, O. Vidal, J. Gisbert, R. Muñoz, J. Maciá, S. Gómez-Codina, J.
Published in
Clinical and Translational Oncology
PurposeTo evaluate the association in the change of circulating tumor cell (CTC) levels and clinical outcomes (PFS and OS) in patients with advanced non-small cell lung cancer (NSCLC) treated homogenously with docetaxel and gemcitabine administered every 2 weeks.MethodsWe prospectively evaluated 37 patients for CTC levels at baseline and after 2 mo...
Yuan, Z. Li, W.-T. Ye, X.-D. Zhu, H.-Y. Peng, W.-J.
Published in
Clinical and Translational Oncology
The established and adapted image biomarkers based on size for tumor burden measurement continue to be applied to hepatocellular carcinoma (HCC) as size measurement can easily be used in clinical practice. However, in the setting of novel targeted therapies and liver directed treatments, simple tumor anatomical changes can be less informative and u...
Rubió-Casadevall, J. Borràs, J. L. Carmona, C. Ameijide, A. Osca, G. Vilardell, L. Izquierdo, A. Galceran, J. Marcos-Gragera, R.
Published in
Clinical and Translational Oncology
IntroductionThe diagnostic approach of Gastrointestinal Stromal Tumours (GIST) was established in 2002. Before this, GIST had been classified with a wide range of histological terms. This fact and the consideration of potential malignity of all these tumours led to a false perception of an increasing incidence.PurposeThis study aimed at evaluating ...
Jiang, X. Ding, M. Qiao, Y. Liu, Y. Liu, L.
Published in
Clinical and Translational Oncology
ObjectiveSince brain metastases (BM) is often accompanied by edema, and endostatin (ES) can prevent tumor tissue edema, we investigated the therapeutic effects of ES combined with radiotherapy in the treatment of BM of NSCLC. We also determined the patients who are suitable for this therapy.MethodsEighty patients with BM of NSCLC were randomly divi...
