Kuroda, Masayuki Saito, Yasushi Aso, Masayuki Yokote, Koutaro
Published in
Chemical & pharmaceutical bulletin
Despite the critical need for lifelong treatment of inherited and genetic diseases, there are no developmental efforts for most such diseases due to their rarity. Recent progress in gene therapy, including the approvals of two products (Glybera and Strimvelis) that may provide patients with sustained effects, has shed light on the development of ge...
Ogata, Fumihiko Nagai, Noriaki Ueta, Erimi Nakamura, Takehiro Kawasaki, Naohito
Published in
Chemical & pharmaceutical bulletin
In this study, we prepared novel adsorbents containing virgin and calcined tapioca products for removing strontium (Sr(II)) and cesium (Cs(I)) from aqueous solutions. The characteristics of tapioca, along with its capacity to adsorb Sr(II) and Cs(I), were evaluated. Multiple tapioca products were prepared and tested. The adsorbent prepared by boili...
Dahlizar, Sabrina Futaki, Mika Okada, Akie Kadhum, Wesam Radhi Todo, Hiroaki Sugibayashi, Kenji
Published in
Chemical & pharmaceutical bulletin
Palmitoyl-glycine-histidine (Pal-GH) is a new low molecular weight gelling agent. It exhibits thixotropic behavior, low viscosity, and high dissolving properties for a wide range of hydrophilic to lipophilic drugs. Orally administered ivermectin (IVM) is used to treat scabies. However, this treatment is associated with well-known side effects, thus...
Karuo, Yukiko Yamada, Kohei Kunishima, Munetaka
Published in
Chemical & pharmaceutical bulletin
Benzylating reagents, 4-(4,6-di-t-butyl-1,3,5-triazin-2-yl)-4-benzylmorpholinium triflate, and related derivatives have been developed. The reagents release benzyl triflate as a benzyl cation equivalent upon heating the solution to 40°C under neutral conditions. The O-benzylation of alcohols using a stoichiometric amount of these reagents afforded ...
Kadoh, Yoichi Miyoshi, Haruko Matsumura, Takehiko Tanaka, Yoshihito Hongu, Mitsuya Kimura, Mayumi Takedomi, Kei Omori, Kenji Kotera, Jun Sasaki, Takashi
...
Published in
Chemical & pharmaceutical bulletin
Phosphodiesterase (PDE) 10A is a dual hydrolase of cAMP and cGMP and highly expressed in striatal medium spiny neurons. Inhibition of PDE10A modulates the activity of medium spiny neurons (MSN) via the regulation of cAMP and cGMP. Signal control of MSN is considered associated with psychotic symptoms. Therefore PDE10A inhibitor is expected as a the...
Li, Jie Zheng, Tu-Cai Jin, Yi Xu, Jian-Guo Yu, Jian-Gang Lv, Yan-Wen
Published in
Chemical & pharmaceutical bulletin
A series of novel quinolone derivatives (8a-j) were synthesized, and their anticancer activities were tested in human cancer cell lines A549, HL-60, and Hela. Compound 8i was found to be 5-times more potent in cell-killing activity for cell lines A549, HL-60, and Hela than the positive control irinotecan or cisplatin, with IC50 of 0.009, 0.008 and ...
Lin, San-Qing Zhou, Zhong-Liu Li, Chun-Yan
Published in
Chemical & pharmaceutical bulletin
Cyprotuoside C (1) and cyprotuoside D (2), two new cycloartane glycosides were isolated from the ethanol extract of the rhizomes of Cyperus rotundus. Their structures were identified as 24R-9, 10-seco-cycloartan-1 (10), 9 (11)-dien-3β, 7β, 24, 25-tetraol 3-O-β-D-xylopyranosyl-(1→4)-[α-L-arabinopyranosyl-(1→6)]-β-D-glucopyranosyl-25-O-β-D-glucuronid...
Zhang, Li Liu, Zhong-Hong Cheng, Xun-Guan Xia, Zhu Liu, Yu Yu, Yu
Published in
Chemical & pharmaceutical bulletin
The application of chemotherapeutics with chemical drugs is always challenged by their high toxicities throughout the body in clinical trials. Here, we reported a smart formulation of docetaxel developed by solid dispersion and effervescent techniques for efficient and safe delivery of chemical drug to lung tissue. To achieve a high delivery to lun...
Liu, Shuoqian Ferreira, Jorge Freire da Silva Liu, Liping Tang, Yuwei Tian, Dongming Liu, Zhonghua Tian, Na
Published in
Chemical & pharmaceutical bulletin
Malaria is the most devastating parasitic disease worldwide. Artemisinin is the only drug that can cure malaria that is resistant to quinine-derived drugs. After the commercial extraction of artemisinin from Artemisia annua, the recovery of dihydroartemisinic acid (DHAA) from artemisinin extraction by-product has the potential to increase artemisin...
Tuğcu-Demiröz, Fatmanur
Published in
Chemical & pharmaceutical bulletin
Liposomal vaginal drug delivery systems are important strategy in the treatment of both topical and systemic diseases. The aim of this study was to develop a vaginal delivery system for benzydamine hydrochloride (BNZ) loaded liposomes dispersed into mucoadhesive gels. The delivery system was also designed for a once a day dosage and to obtain contr...
