Klöppel, Sophie Richarz, René Wirtz, Daniel A Vasenda, Natalia König, Gabriele M Crüsemann, Max
Published in
Chembiochem : a European journal of chemical biology
d-Phenyllactate (PLA) is a component of the selective Gq protein inhibitor and nonribosomal cyclic depsipeptide FR900359 (FR). Here we report a detailed biochemical investigation of PLA biosynthesis and its incorporation into the natural product FR. The enzyme FrsC, member of the lactate/malate dehydrogenase superfamily, was shown to catalyze the f...
Huang, Wei Huang, Siming Chen, Guosheng Ouyang, Gangfeng
Published in
Chembiochem : a European journal of chemical biology
The highly efficient and specific catalysis of enzymes allows them to recognize a myriad of substrates, which enables biosensing. However, the fragility of natural enzymes severely restricts their practical applications. Metal-organic frameworks (MOFs) with porous networks and attractive functions have been intelligently employed as supports to enc...
Huang, Ying Valiante, Vito
Published in
Chembiochem : a European journal of chemical biology
Drimane-type sesquiterpenes are a class of compounds produced by a wide range of organisms, initially isolated and characterized in plants. Meanwhile, in the past 20-30 years, a large number of novel structures from many divergent fungi have been elucidated. Recently, the biosynthesis of drimane-type sesquiterpenes and their esters has been explain...
Zhou, Jia Du, Wei Shao, Tao Li, Zheng Zhang, Duoteng Wang, Lan Fang, Zhijie Li, Jie Wu, Qiong Zhang, Chengwu
...
Published in
Chembiochem : a European journal of chemical biology
Impaired mitophagy hinders the clearance of damaged mitochondria, inducing pathological states. Knowledge of this phenomenon is key to diagnosing certain diseases and understanding their pathogenesis. Mitophagy involves an acidization process that could serve as an ideal detection target. In this work, we designed and synthesized a mitochondrial-ta...
Wang, Zengtao Chen, Dongmei Fan, Qiqi Wu, Zhihao Dong, Jinyun Cui, Jiahua Wang, Jie Xu, Ting Meng, Qingqing Li, Shaoshun
...
Published in
Chembiochem : a European journal of chemical biology
Cytochrome P450 (CYP) 1B1 has been found to be overexpressed specifically in tumor tissues at an early stage, which makes it a potential cancer biomarker for molecular imaging. Multimodal imaging combines different imaging modalities and offers more comprehensive information. Thus, imaging probes bearing more than one kind of signal fragment have b...
Mohapatra, Ranjan K Kandi, Venkataramana Verma, Sarika Dhama, Kuldeep
Published in
Chembiochem : a European journal of chemical biology
The SARS-CoV-2 virus has shown increased ability to mutate over the past two years, especially in the regions of the spike protein and receptor binding sites. Omicron (B.1.1.529) is the fifth variant of concern (VOC) after the emergence of the Alpha, Beta, Gamma, and Delta VOCs of SARS-CoV-2. This new variant has now circulated in 128 countries and...
Couillaud, Julie Duquesne, Katia Iacazio, Gilles
Published in
Chembiochem : a European journal of chemical biology
The structural diversity of terpenes is particularly notable and many studies are carried out to increase it further. In the terpene biosynthetic pathway this diversity is accessible from only two common precursors, i. e. isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Methods recently developed (e. g. the Terpene Mini Path) ha...
Pina, André F Sousa, Sérgio F Cerqueira, Nuno M F S A
Published in
Chembiochem : a European journal of chemical biology
The catalytic mechanism of Pdx2 was studied with atomic detail employing the computational ONIOM hybrid QM/MM methodology. Pdx2 employs a Cys-His-Glu catalytic triad to deaminate glutamine to glutamate and ammonia - the source of the nitrogen of pyridoxal 5'-phosphate (PLP). This enzyme is, therefore, a rate-limiting step in the PLP biosynthetic pa...
Jethava, Krupal P Prakash, Priya Manchanda, Palak Arora, Harshit Chopra, Gaurav
Published in
Chembiochem : a European journal of chemical biology
Targeting live cell organelles is essential for imaging, understanding, and controlling specific biochemical processes. Typically, fluorescent probes with distinct structural scaffolds are used to target specific cell organelles. Here, we have designed a modular one-step synthetic strategy using a common reaction intermediate to develop new lysosom...
Planeta Kepp, Kasper
Published in
Chembiochem : a European journal of chemical biology
Zinc is well-known to have a central role in human inflammation and immunity and is itself an anti-inflammatory and antiviral agent. Despite its massively documented role in such processes, the underlying chemistry of zinc in relation to specific proteins and pathways of the immune system has not received much focus. This short review provides an o...
