Schäbler, Stefan Amatobi, Kelechi M. Horn, Melanie Rieger, Dirk Helfrich-Förster, Charlotte Mueller, Martin J. Wegener, Christian Fekete, Agnes
Published in
Cellular and Molecular Life Sciences
The fruit fly Drosophila is a prime model in circadian research, but still little is known about its circadian regulation of metabolism. Daily rhythmicity in levels of several metabolites has been found, but knowledge about hydrophobic metabolites is limited. We here compared metabolite levels including lipids between period 01 ( per 01 ) clock mut...
Wetzel, Alexandra Scholtka, Bettina Gerecke, Christian Kleuser, Burkhard
Published in
Cellular and Molecular Life Sciences
Ulcerative colitis (UC) is characterized by relapsing–remitting inflammatory episodes paralleled by varying cytokine levels, suggesting that switching epigenetic processes might be involved. However, the epigenetic impact on cytokine levels in colitis is mostly unexplored. The heterodimeric interleukin (IL)-12 cytokine family have various functions...
Medunjanin, Senad Putzier, Maximilian Nöthen, Till Weinert, Sönke Kähne, Thilo Luani, Blerim Zuschratter, Werner Braun-Dullaeus, Ruediger C.
Published in
Cellular and Molecular Life Sciences
The transcription factors of the nuclear factor κB (NF-κB) family play a pivotal role in the cellular response to DNA damage. Genotoxic stress-induced activation of NF-κB differs from the classical canonical pathway by shuttling of the NF-κB Essential Modifier (IKKγ/NEMO) subunit through the nucleus. Here, we show that DNA-dependent protein kinase ...
Santiago, Mafalda Antunes, Claudia Guedes, Marta Iacovino, Michelina Kyba, Michael Reik, Wolf Sousa, Nuno Pinto, Luísa Branco, Miguel R. Marques, C. Joana
...
Published in
Cellular and Molecular Life Sciences
Ghosh, Sayan Stepicheva, Nadezda Yazdankhah, Meysam Shang, Peng Watson, Alan M. Hose, Stacey Liu, Haitao Weiss, Joseph Zigler, J. Samuel Jr Valapala, Mallika
...
Published in
Cellular and Molecular Life Sciences
Lipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of several diseases including cancer, diabetes, obesity, and multiple sclerosis. Herein, we discuss th...
Kauppinen, Anu
Published in
Cellular and Molecular Life Sciences
Prolonged life expectancies contribute to the increasing prevalence of age-related macular degeneration (AMD) that is already the leading cause of severe vision loss among the elderly in developed countries. In dry AMD, the disease culminates into vast retinal atrophy, whereas the wet form is characterized by retinal edema and sudden vision loss du...
Gemenetzi, M. Lotery, A. J.
Published in
Cellular and Molecular Life Sciences
The study of epigenetics has explained some of the ‘missing heritability’ of age-related macular degeneration (AMD). The epigenome also provides a substantial contribution to the organisation of the functional retina. There is emerging evidence of specific epigenetic mechanisms associated with AMD. This ‘AMD epigenome’ may offer the chance to devel...
Lugano, Roberta Ramachandran, Mohanraj Dimberg, Anna
Published in
Cellular and molecular life sciences : CMLS
Tumor vascularization occurs through several distinct biological processes, which not only vary between tumor type and anatomic location, but also occur simultaneously within the same cancer tissue. These processes are orchestrated by a range of secreted factors and signaling pathways and can involve participation of non-endothelial cells, such as ...
Mikuła-Pietrasik, Justyna Niklas, Arkadiusz Uruski, Paweł Tykarski, Andrzej Książek, Krzysztof
Published in
Cellular and molecular life sciences : CMLS
In contrast to the well-recognized replicative and stress-induced premature senescence of normal somatic cells, mechanisms and clinical implications of senescence of cancer cells are still elusive and uncertain from patient-oriented perspective. Moreover, recent years provided multiple pieces of evidence that cancer cells may undergo senescence not...
Zámbó, Boglárka Mózner, Orsolya Bartos, Zsuzsa Török, György Várady, György Telbisz, Ágnes Homolya, László Orbán, Tamás I Sarkadi, Balázs
Published in
Cellular and molecular life sciences : CMLS
The human ABCG2 multidrug transporter plays a crucial role in the absorption and excretion of xeno- and endobiotics; thus the relatively frequent polymorphic and mutant ABCG2 variants in the population may significantly alter disease conditions and pharmacological effects. Low-level or non-functional ABCG2 expression may increase individual drug to...
