Mammadzada, Parviz Corredoira, Pablo M. André, Helder
Published in
Cellular and Molecular Life Sciences
Understanding the mechanisms that underlie age-related macular degeneration (AMD) has led to the identification of key molecules. Hypoxia-inducible transcription factors (HIFs) have been associated with choroidal neovascularization and the progression of AMD into the neovascular clinical phenotype (nAMD). HIFs regulate the expression of multiple gr...
Wang, Jia Zheng, Xiang Peng, Qiu Zhang, Xuemei Qin, Zailong
Published in
Cellular and Molecular Life Sciences
Eph (erythropoietin-producing hepatoma) receptors and Ephrin ligands constitute the largest subfamily of receptor tyrosine kinase (RTK), which were first discovered in tumors. Heretofore, Eph protein has been shown to be involved in various tumor biological behaviors including proliferation and progression. The occurrence of specific types of tumor...
Seo, Jiyeon Park, Mikyoung
Published in
Cellular and Molecular Life Sciences
The progression of cancers and neurodegenerative disorders is largely defined by a set of molecular determinants that are either complementarily deregulated, or share remarkably overlapping functional pathways. A large number of such molecules have been demonstrated to be involved in the progression of both diseases. In this review, we particularly...
Li, Pan Zhang, Lijun Li, Zhifang Xu, Chunlong Du, Xuguang Wu, Sen
Published in
Cellular and Molecular Life Sciences
Efficient exogenous DNA integration can be mediated by Cas9 through the non-homology end-joining pathway. However, such integrations are often imprecise and contain a variety of mutations at the junctions between the external DNA and the genomic loci. Here we describe a microhomology-dependent targeted integration method, designated MITI, for preci...
Wang, Ziqiang Li, Kun Chen, Wei Wang, Xiaoxia Huang, Yikun Wang, Weiming Wu, Wanjun Cai, Zhiming Huang, Weiren
Published in
Cellular and Molecular Life Sciences
The elevated expression of immune checkpoints by the tumor microenvironment is associated with poor prognosis in several cancers due to the exhaustion of tumor-infiltrating lymphocytes (TILs), and the effective suppression of the expression of these genes is key to reversing the exhaustion of TILs. Herein, we determined that serine/arginine-rich sp...
Hua, Wan ten Dijke, Peter Kostidis, Sarantos Giera, Martin Hornsveld, Marten
Published in
Cellular and Molecular Life Sciences
Metastasis is the most frequent cause of death in cancer patients. Epithelial-to-mesenchymal transition (EMT) is the process in which cells lose epithelial integrity and become motile, a critical step for cancer cell invasion, drug resistance and immune evasion. The transforming growth factor-β (TGFβ) signaling pathway is a major driver of EMT. Inc...
Arasu, Uma Thanigai Deen, Ashik Jawahar Pasonen-Seppänen, Sanna Heikkinen, Sami Lalowski, Maciej Kärnä, Riikka Härkönen, Kai Mäkinen, Petri Lázaro-Ibáñez, Elisa Siljander, Pia R-M
...
Published in
Cellular and Molecular Life Sciences
Intercellular communication is fundamental to the survival and maintenance of all multicellular systems, whereas dysregulation of communication pathways can drive cancer progression. Extracellular vesicles (EVs) are mediators of cell-to-cell communication that regulate a variety of cellular processes involved in tumor progression. Overexpression of...
Sironen, Anu Shoemark, Amelia Patel, Mitali Loebinger, Michael R Mitchison, Hannah M
Published in
Cellular and molecular life sciences : CMLS
The core axoneme structure of both the motile cilium and sperm tail has the same ultrastructural 9 + 2 microtubular arrangement. Thus, it can be expected that genetic defects in motile cilia also have an effect on sperm tail formation. However, recent studies in human patients, animal models and model organisms have indicated that there are differe...
Gigli-Bisceglia, Nora Engelsdorf, Timo Hamann, Thorsten
Published in
Cellular and molecular life sciences : CMLS
The walls surrounding the cells of all land-based plants provide mechanical support essential for growth and development as well as protection from adverse environmental conditions like biotic and abiotic stress. Composition and structure of plant cell walls can differ markedly between cell types, developmental stages and species. This implies that...
Ewald, Jan Sieber, Patricia Garde, Ravindra Lang, Stefan N. Schuster, Stefan Ibrahim, Bashar
Published in
Cellular and Molecular Life Sciences
Pathogenic microorganisms entail enormous problems for humans, livestock, and crop plants. A better understanding of the different infection strategies of the pathogens enables us to derive optimal treatments to mitigate infectious diseases or develop vaccinations preventing the occurrence of infections altogether. In this review, we highlight the ...
