Fani, Giulia La Torre, Chiara Ester Cascella, Roberta Cecchi, Cristina Vendruscolo, Michele Chiti, Fabrizio
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Cellular and molecular life sciences : CMLS
Alzheimer's disease is characterized by the accumulation in the brain of the amyloid β (Aβ) peptide in the form of senile plaques. According to the amyloid hypothesis, the aggregation process of Aβ also generates smaller soluble misfolded oligomers that contribute to disease progression. One of the mechanisms of Aβ oligomer cytotoxicity is the aber...
Rueter, Johanna Rimbach, Gerald Huebbe, Patricia
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Cellular and Molecular Life Sciences
Human apolipoprotein E (APOE), originally known for its role in lipid metabolism, is polymorphic with three major allele forms, namely, APOEε2 , APOEε3 , and APOEε4, leading to three different human APOE isoforms. The ε4 allele is a genetic risk factor for Alzheimer’s disease (AD); therefore, the vast majority of APOE research focuses on its role i...
Feng, Yue Chen, Dake Wang, Tiansu Zhou, Jiawei Xu, Wenning Xiong, Hao Bai, Rong Wu, Shang Li, Jialian Li, Fenge
...
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Cellular and Molecular Life Sciences
Sertoli cells contribute to the formation of the blood-testis barrier (BTB), which is necessary for normal spermatogenesis. Recently, microRNAs (miRNAs) have emerged as posttranscriptional regulatory elements in BTB function during spermatogenesis. Our previous study has shown that miR-181c or miR-181d (miR-181c/d) is highly expressed in testes fro...
NavaneethaKrishnan, Saranya Law, Vincent Lee, Jungkwon Rosales, Jesusa L. Lee, Ki-Young
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Cellular and Molecular Life Sciences
Loss of cyclin-dependent kinase 5 (Cdk5) in the mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) increases ER–mitochondria tethering and ER Ca2+ transfer to the mitochondria, subsequently increasing mitochondrial Ca2+ concentration ([Ca2+]mt). This suggests a role for Cdk5 in regulating intracellular Ca2+ dynamics, but how Cdk5 i...
Embarc-Buh, Azman Francisco-Velilla, Rosario Garcia-Martin, Juan Antonio Abellan, Salvador Ramajo, Jorge Martinez-Salas, Encarnacion
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Cellular and Molecular Life Sciences
Selective translation allows to orchestrate the expression of specific proteins in response to different signals through the concerted action of cis-acting elements and RNA-binding proteins (RBPs). Gemin5 is a ubiquitous RBP involved in snRNP assembly. In addition, Gemin5 regulates translation of different mRNAs through apparently opposite mechanis...
Salminen, Antero
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Cellular and Molecular Life Sciences
The antagonistic pleiotropy hypothesis is a well-known evolutionary theory to explain the aging process. It proposes that while a particular gene may possess beneficial effects during development, it can exert deleterious properties in the aging process. The aryl hydrocarbon receptor (AhR) has a significant role during embryogenesis, but later in l...
Zhang, Yunhui Liu, Wenjie Yuan, Weiquan Cai, Zhaopeng Ye, Guiwen Zheng, Guan Xu, Chenhao Wang, Xinglang Zeng, Chenying Mi, Rujia
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Cellular and molecular life sciences : CMLS
An imbalance of human mesenchymal stem cells (hMSCs) adipogenic and osteogenic differentiation is crucial in the pathogenesis of osteoporosis, and elucidation of the underlying mechanism is urgently needed. APPL1, an adaptor protein of the adiponectin receptor, was recently shown to be closely related to bone mass. However, the role of APPL1 in the...
Dreier, Jesper E. Prestel, Andreas Martins, João M. Brøndum, Sebastian S. Nielsen, Olaf Garbers, Anna E. Suga, Hiroaki Boomsma, Wouter Rogers, Joseph M. Hartmann-Petersen, Rasmus
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Cellular and Molecular Life Sciences
Ubiquitin is a small, globular protein that is conjugated to other proteins as a posttranslational event. A palette of small, folded domains recognizes and binds ubiquitin to translate and effectuate this posttranslational signal. Recent computational studies have suggested that protein regions can recognize ubiquitin via a process of folding upon ...
Li, Qijing Zhong, Jianghong Luo, Huqiao Urbonaviciute, Vilma Xu, Zhongwei He, Chang Holmdahl, Rikard
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Cellular and Molecular Life Sciences
A breach of T cell tolerance is considered as a major step in the pathogenesis of rheumatoid arthritis. In collagen-induced arthritis (CIA) model, immunization with type II collagen (COL2) leads to arthritis in mice through T cells responding to the immunodominant COL2259–273 peptide. T cells could escape from thymus negative selection because endo...
Arneson, Douglas Zhang, Guanglin Ahn, In Sook Ying, Zhe Diamante, Graciel Cely, Ingrid Palafox-Sanchez, Victoria Gomez-Pinilla, Fernando Yang, Xia
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Cellular and molecular life sciences : CMLS
The etiology of mild traumatic brain injury (mTBI) remains elusive due to the tissue and cellular heterogeneity of the affected brain regions that underlie cognitive impairments and subsequent neurological disorders. This complexity is further exacerbated by disrupted circuits within and between cell populations across brain regions and the periphe...
