Hung, Chiu-Yueh Zhu, Chuanshu Kittur, Farooqahmed S. He, Maotao Arning, Erland Zhang, Jianhui Johnson, Asia J. Jawa, Gurpreet S. Thomas, Michelle D. Ding, Tomas T.
...
Published in
Cellular and Molecular Life Sciences
Pathophysiology associated with Huntington’s disease (HD) has been studied extensively in various cell and animal models since the 1993 discovery of the mutant huntingtin (mHtt) with abnormally expanded polyglutamine (polyQ) tracts as the causative factor. However, the sequence of early pathophysiological events leading to HD still remains elusive....
Keable, Ryan Hu, Shangfeng Pfundstein, Grant Kozlova, Irina Su, Feifei Du, Ximing Yang, Hongyuan Gunnersen, Jenny Schachner, Melitta Leshchyns’ka, Iryna
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Published in
Cellular and Molecular Life Sciences
Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), also known as β-secretase, is an aspartic protease. The sorting of this enzyme into Rab11-positive recycling endosomes regulates the BACE1-mediated cleavage of its substrates, however, the mechanisms underlying this targeting remain poorly understood. The neural cell adhesion molecule 2...
Schlossarek, Dennis Luzarowski, Marcin Sokołowska, Ewelina M. Thirumalaikumar, Venkatesh P. Dengler, Lisa Willmitzer, Lothar Ewald, Jennifer C. Skirycz, Aleksandra
Published in
Cellular and Molecular Life Sciences
In budding yeast Saccharomyces cerevisiae , the switch from aerobic fermentation to respiratory growth is separated by a period of growth arrest, known as the diauxic shift, accompanied by a significant metabolic rewiring, including the derepression of gluconeogenesis and the establishment of mitochondrial respiration. Previous studies reported hun...
Sala-Gaston, Joan Pedrazza, Leonardo Ramirez, Juanma Martinez-Martinez, Arturo Rawlins, Lettie E. Baple, Emma L. Crosby, Andrew H. Mayor, Ugo Ventura, Francesc Rosa, Jose Luis
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Published in
Cellular and Molecular Life Sciences
HERC2 gene encodes an E3 ubiquitin ligase involved in several cellular processes by regulating the ubiquitylation of different protein substrates. Biallelic pathogenic sequence variants in the HERC2 gene are associated with HERC2 Angelman-like syndrome. In pathogenic HERC2 variants, complete absence or marked reduction in HERC2 protein levels are o...
Kumar, Sudhir Valansi, Clari Haile, Meseret T. Li, Xiaohui Flyak, Kateryna Dwivedy, Abhisek Abatiyow, Biley A. Leeb, Amanda S. Kennedy, Spencer Y. Camargo, Nelly M.
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Published in
Cellular and Molecular Life Sciences
Cell fusion of female and male gametes is the climax of sexual reproduction. In many organisms, the Hapless 2 (HAP2) family of proteins play a critical role in gamete fusion. We find that Plasmodium falciparum , the causative agent of human malaria, expresses two HAP2 proteins: Pf HAP2 and Pf HAP2p. These proteins are present in stage V gametocytes...
Zhang, Ejuan Ma, Zhiyong Lu, Mengji
Published in
Cellular and molecular life sciences : CMLS
Toll-like receptors (TLRs) comprise a class of highly conserved molecules that recognize pathogen-associated molecular patterns and play a vital role in host defense against multiple viral infectious diseases. Although TLRs are highly expressed on innate immune cells and play indirect roles in regulating antiviral adaptive immune responses, intrins...
Bakalkin, Georgy
Published in
Cellular and molecular life sciences : CMLS
Each cerebral hemisphere is functionally connected to the contralateral side of the body through the decussating neural tracts. The crossed neural pathways set a basis for contralateral effects of brain injury such hemiparesis and hemiplegia as it has been already noted by Hippocrates. Recent studies demonstrated that, in addition to neural mechani...
Navarro, Natalia Molist, Carla Sansa-Girona, Júlia Zarzosa, Patricia Gallo-Oller, Gabriel Pons, Guillem Magdaleno, Ainara Guillén, Gabriela Hladun, Raquel Garrido, Marta
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Published in
Cellular and Molecular Life Sciences
The majority of current cancer therapies are aimed at reducing tumour growth, but there is lack of viable pharmacological options to reduce the formation of metastasis. This is a paradox, since more than 90% of cancer deaths are attributable to metastatic progression. Integrin alpha9 (ITGA9) has been previously described as playing an essential rol...
Wakao, Shohei Oguma, Yo Kushida, Yoshihiro Kuroda, Yasumasa Tatsumi, Kazuki Dezawa, Mari
Published in
Cellular and Molecular Life Sciences
Stem cells undergo cytokine-driven differentiation, but this process often takes longer than several weeks to complete. A novel mechanism for somatic stem cell differentiation via phagocytosing ‘model cells’ (apoptotic differentiated cells) was found to require only a short time frame. Pluripotent-like Muse cells, multipotent mesenchymal stem cells...
Lemmens, Veerle Thevelein, Bart Vella, Yana Kankowski, Svenja Leonhard, Julia Mizuno, Hideaki Rocha, Susana Brône, Bert Meier, Jochen C Hendrix, Jelle
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Published in
Cellular and molecular life sciences : CMLS
Glycine receptors (GlyRs) are ligand-gated pentameric chloride channels in the central nervous system. GlyR-α3 is a possible target for chronic pain treatment and temporal lobe epilepsy. Alternative splicing into K or L variants determines the subcellular fate and function of GlyR-α3, yet it remains to be shown whether its different splice variants...
