Radwitz, Jennifer Hausrat, Torben J. Heisler, Frank F. Janiesch, Philipp C. Pechmann, Yvonne Rübhausen, Michael Kneussel, Matthias
Published in
Cellular and Molecular Life Sciences
Microtubules are dynamic polymers of α/β-tubulin. They regulate cell structure, cell division, cell migration, and intracellular transport. However, functional contributions of individual tubulin isotypes are incompletely understood. The neuron-specific β-tubulin Tubb3 displays highest expression around early postnatal periods characterized by exub...
Labat-de-Hoz, Leticia Comas, Laura Rubio-Ramos, Armando Casares-Arias, Javier Fernández-Martín, Laura Pantoja-Uceda, David Martín, M. Teresa Kremer, Leonor Jiménez, M. Angeles Correas, Isabel
...
Published in
Cellular and Molecular Life Sciences
In INF2—a formin linked to inherited renal and neurological disease in humans—the DID is preceded by a short N-terminal extension of unknown structure and function. INF2 activation is achieved by Ca2+-dependent association of calmodulin (CaM). Here, we show that the N-terminal extension of INF2 is organized into two α-helices, the first of which is...
Pastor, William A Kwon, Sin Young
Published in
Cellular and molecular life sciences : CMLS
The placenta has a methylome dramatically unlike that of any somatic cell type. Among other distinctions, it features low global DNA methylation, extensive "partially methylated domains" packed in dense heterochromatin and methylation of hundreds of CpG islands important in somatic development. These features attract interest in part because a subs...
Tavčar Verdev, Petra Potokar, Maja Korva, Miša Resman Rus, Katarina Kolenc, Marko Avšič Županc, Tatjana Zorec, Robert Jorgačevski, Jernej
Published in
Cellular and molecular life sciences : CMLS
Astrocytes, an abundant type of glial cells, are the key cells providing homeostasis in the central nervous system. Due to their susceptibility to infection, combined with high resilience to virus-induced cell death, astrocytes are now considered one of the principal types of cells, responsible for virus retention and dissemination within the brain...
Alan, Parsa Vandevoorde, Kurt R Joshi, Bharat Cardoen, Ben Gao, Guang Mohammadzadeh, Yahya Hamarneh, Ghassan Nabi, Ivan R
Published in
Cellular and molecular life sciences : CMLS
Mitochondria are major sources of cytotoxic reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, that when uncontrolled contribute to cancer progression. Maintaining a finely tuned, healthy mitochondrial population is essential for cellular homeostasis and survival. Mitophagy, the selective elimination of mitochondria by autopha...
Wohlfarter, Yvonne Eidelpes, Reiner Yu, Ryan D. Sailer, Sabrina Koch, Jakob Karall, Daniela Scholl-Bürgi, Sabine Amberger, Albert Hillen, Hauke S. Zschocke, Johannes
...
Published in
Cellular and Molecular Life Sciences
Multifunctional proteins are challenging as it can be difficult to confirm pathomechanisms associated with disease-causing genetic variants. The human 17β-hydroxysteroid dehydrogenase 10 (HSD10) is a moonlighting enzyme with at least two structurally and catalytically unrelated functions. HSD10 disease was originally described as a disorder of isol...
Bernhard, P. Feilen, T. Rogg, M. Fröhlich, K. Cosenza-Contreras, M. Hause, F. Schell, C. Schilling, O.
Published in
Cellular and Molecular Life Sciences
Clonal isolation is an integral step of numerous workflows in genome editing and cell engineering. It comprises the isolation of a single progenitor cell from a defined cell line population with subsequent expansion to obtain a monoclonal cell population. This process is associated with transient loss of cell–cell contacts and absence of a multicel...
Davies, Emma S Morphew, Russell M Cutress, David Morton, A Jennifer McBride, Sebastian
Published in
Cellular and molecular life sciences : CMLS
Alzheimer's disease is a chronic neurodegenerative disease that accounts for up to 80% of all dementias. Characterised by deteriorations of memory and cognitive function, the key neuropathological features are accumulations of β-amyloid and hyperphosphorylated tau, as 'plaques' and 'tangles', respectively. Despite extensive study, however, the exac...
Heinze, Anika Schuldt, Cara Khudayberdiev, Sharof van Bommel, Bas Hacker, Daniela Schulz, Toni G Stringhi, Ramona Marcello, Elena Mikhaylova, Marina Rust, Marco B
...
Published in
Cellular and molecular life sciences : CMLS
The vast majority of excitatory synapses are formed on small dendritic protrusions termed dendritic spines. Dendritic spines vary in size and density that are crucial determinants of excitatory synaptic transmission. Aberrations in spine morphogenesis can compromise brain function and have been associated with neuropsychiatric disorders. Actin fila...
Morente-López, Miriam Mato-Basalo, Rocío Lucio-Gallego, Sergio Silva-Fernández, Lucía González-Rodríguez, Alba De Toro, Fco. Javier Fafián-Labora, Juan A. Arufe, María C.
Published in
Cellular and Molecular Life Sciences
Osteoarthritis (OA) is closely linked to the increase in the number of senescent cells in joint tissues, and the senescence-associated secretory phenotype (SASP) is implicated in cartilage degradation. In the last decade, extracellular vesicles (EV) in combination with the use of miRNAs to modify post-transcriptional expressions of multiple genes h...
