Taghinezhad-S, Sedigheh Keyvani, Hossein Bermúdez-Humarán, Luis G. Donders, Gilbert G. G. Fu, Xiangsheng Mohseni, Amir Hossein
Published in
Cellular and Molecular Life Sciences
Most cervical cancer (CxCa) are related to persistent infection with high-risk human papillomavirus (HR-HPV) in the cervical mucosa, suggesting that an induction of mucosal cell-mediated immunity against HR-HPV oncoproteins can be a promising strategy to fight HPV-associated CxCa. From this perspective, many pre-clinical and clinical trials have pr...
Barabutis, Nektarios
Published in
Cellular and Molecular Life Sciences
P53 is a tumor suppressor protein, associated with strong anti-inflammatory activities. Recent evidence suggest that this transcription factor counteracts lung inflammatory diseases, including the lethal acute respiratory distress syndrome. Herein we provide a brief discussion on the relevant topic.
Rovini, Amandine Gurnev, Philip A. Beilina, Alexandra Queralt-Martín, María Rosencrans, William Cookson, Mark R. Bezrukov, Sergey M. Rostovtseva, Tatiana K.
Published in
Cellular and Molecular Life Sciences
An intrinsically disordered neuronal protein α-synuclein (αSyn) is known to cause mitochondrial dysfunction, contributing to loss of dopaminergic neurons in Parkinson’s disease. Through yet poorly defined mechanisms, αSyn crosses mitochondrial outer membrane and targets respiratory complexes leading to bioenergetics defects. Here, using neuronally ...
Liu, Huajie Temel, Yasin Boonstra, Jackson Hescham, Sarah
Published in
Cellular and Molecular Life Sciences
Deep brain stimulation is used to alleviate symptoms of neurological and psychiatric disorders including Parkinson’s disease, epilepsy, and obsessive–compulsive-disorder. Electrically stimulating limbic structures has been of great interest, and in particular, the region of the fornix. We conducted a systematic search for studies that reported clin...
Božić, Mićo Verkhratsky, Alexei Zorec, Robert Stenovec, Matjaž
Published in
Cellular and molecular life sciences : CMLS
Astrocytes are the key homeostatic cells in the central nervous system; initiation of reactive astrogliosis contributes to neuroinflammation. Pro-inflammatory cytokine interferon γ (IFNγ) induces the expression of the major histocompatibility complex class II (MHCII) molecules, involved in antigen presentation in reactive astrocytes. The pathway fo...
Giri, Rajanish Bhardwaj, Taniya Shegane, Meenakshi Gehi, Bhuvaneshwari R Kumar, Prateek Gadhave, Kundlik Oldfield, Christopher J Uversky, Vladimir N
Published in
Cellular and molecular life sciences : CMLS
The recently emerged coronavirus designated as SARS-CoV-2 (also known as 2019 novel coronavirus (2019-nCoV) or Wuhan coronavirus) is a causative agent of coronavirus disease 2019 (COVID-19), which is rapidly spreading throughout the world now. More than 1.21 million cases of SARS-CoV-2 infection and more than 67,000 COVID-19-associated mortalities ...
Liu, Huajie Temel, Yasin Boonstra, Jackson Hescham, Sarah
Published in
Cellular and Molecular Life Sciences
Werkman, Inge L. Lentferink, Dennis H. Baron, Wia
Published in
Cellular and Molecular Life Sciences
Macroglia, comprising astrocytes and oligodendroglial lineage cells, have long been regarded as uniform cell types of the central nervous system (CNS). Although regional morphological differences between these cell types were initially described after their identification a century ago, these differences were largely ignored. Recently, accumulating...
Mercurio, Ivan Tragni, Vincenzo Busto, Francesco De Grassi, Anna Pierri, Ciro Leonardo
Published in
Cellular and molecular life sciences : CMLS
The recent severe acute respiratory syndrome, known as Coronavirus Disease 2019 (COVID-19) has spread so much rapidly and severely to induce World Health Organization (WHO) to declare a state of emergency over the new coronavirus SARS-CoV-2 pandemic. While several countries have chosen the almost complete lock-down for slowing down SARS-CoV-2 sprea...
Connell, James W Allison, Rachel J Rodger, Catherine E Pearson, Guy Zlamalova, Eliska Reid, Evan
Published in
Cellular and molecular life sciences : CMLS
Mutations in the gene encoding the microtubule severing ATPase spastin are the most frequent cause of hereditary spastic paraplegia, a genetic condition characterised by length-dependent axonal degeneration. Here, we show that HeLa cells lacking spastin and embryonic fibroblasts from a spastin knock-in mouse model become highly polarised and develo...
