Galasso, Marilisa Dalla Pozza, Elisa Chignola, Roberto Gambino, Simona Cavallini, Chiara Quaglia, Francesca Maria Lovato, Ornella Dando, Ilaria Malpeli, Giorgio Krampera, Mauro
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Published in
Cellular and Molecular Life Sciences
Chronic lymphocytic leukemia (CLL) is an incurable disease characterized by an extremely variable clinical course. We have recently shown that high catalase ( CAT ) expression identifies patients with an aggressive clinical course. Elucidating mechanisms regulating CAT expression in CLL is preeminent to understand disease mechanisms and develop str...
Klaver, Dominik Gander, Hubert Dobler, Gabriele Rahm, Andrea Thurnher, Martin
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Cellular and Molecular Life Sciences
The cytoprotective ATP receptor P2Y11 is upregulated during M2 macrophage differentiation and contributes to the anti-inflammatory properties of this macrophage subset. Here, we studied P2Y11-induced reprogramming of human M2 macrophages at the level of mRNA and protein expression. Upregulation of IL-1 receptor (IL-1R) and its known downstream effe...
Altés, Gisela Vaquero, Marta Cuesta, Sara Anerillas, Carlos Macià, Anna Espinet, Carme Ribera, Joan Bellusci, Saverio Klein, Ophir D. Yeramian, Andree
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Published in
Cellular and Molecular Life Sciences
The Wolffian ducts (WD) are paired epithelial tubules central to the development of the mammalian genitourinary tract. Outgrowths from the WD known as the ureteric buds (UB) generate the collecting ducts of the kidney. Later during development, the caudal portion of the WD will form the vas deferens, epididymis and seminal vesicle in males, and wil...
Meléndez, Ana Valeria Velasco Cárdenas, Rubí M.-H. Lagies, Simon Strietz, Juliane Siukstaite, Lina Thomas, Oliver S. Tomisch, Jana Weber, Wilfried Kammerer, Bernd Römer, Winfried
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Published in
Cellular and Molecular Life Sciences
The link between cancer and aberrant glycosylation has recently become evident. Glycans and their altered forms, known as tumour-associated carbohydrate antigens (TACAs), are diverse, complex and difficult to target therapeutically. Lectins are naturally occurring glycan-binding proteins that offer a unique opportunity to recognise TACAs. T cells ...
Brandhofer, Markus Hoffmann, Adrian Blanchet, Xavier Siminkovitch, Elena Rohlfing, Anne-Katrin El Bounkari, Omar Nestele, Jeremy A. Bild, Alexander Kontos, Christos Hille, Kathleen
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Published in
Cellular and Molecular Life Sciences
To fulfil its orchestration of immune cell trafficking, a network of chemokines and receptors developed that capitalizes on specificity, redundancy, and functional selectivity. The discovery of heteromeric interactions in the chemokine interactome has expanded the complexity within this network. Moreover, some inflammatory mediators, not structural...
Ortega-Forte, Enrique Hernández-García, Samanta Vigueras, Gloria Henarejos-Escudero, Paula Cutillas, Natalia Ruiz, José Gandía-Herrero, Fernando
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Cellular and Molecular Life Sciences
Oncosis (from Greek ónkos , meaning “swelling”) is a non-apoptotic cell death process related to energy depletion. In contrast to apoptosis, which is the main form of cell death induced by anticancer drugs, oncosis has been relatively less explored but holds potential to overcome drug resistance phenomena. In this study, we report a novel rationall...
Gout, Dennis Y. Groen, Lotte S. van Egmond, Marjolein
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Cellular and Molecular Life Sciences
Monoclonal antibody (mAb) therapy has successfully been introduced as treatment of several lymphomas and leukemias. However, solid tumors reduce the efficacy of mAb therapy because of an immune-suppressive tumor micro-environment (TME), which hampers activation of effector immune cells. Pro-inflammatory cytokine therapy may counteract immune suppre...
Xie, Haibo Li, Mingzhu Kang, Yunsi Zhang, Jingjing Zhao, Chengtian
Published in
Cellular and Molecular Life Sciences
Scoliosis is a common spinal deformity that considerably affects the physical and psychological health of patients. Studies have shown that genetic factors play an important role in scoliosis. However, its etiopathogenesis remain unclear, partially because of the genetic heterogeneity of scoliosis and the lack of appropriate model systems. Recently...
Zaballos, Miguel A. Acuña-Ruiz, Adrián Morante, Marta Riesco-Eizaguirre, Garcilaso Crespo, Piero Santisteban, Pilar
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Cellular and Molecular Life Sciences
Background RAS-to-ERK signaling is crucial for the onset and progression of advanced thyroid carcinoma, and blocking ERK dimerization provides a therapeutic benefit in several human carcinomas. Here we analyzed the effects of DEL-22379, a relatively specific ERK dimerization inhibitor, on the activation of the RAS-to-ERK signaling cascade and on tu...
Cercillieux, Angelique Ciarlo, Eleonora Canto, Carles
Published in
Cellular and Molecular Life Sciences
Alterations in cellular nicotinamide adenine dinucleotide (NAD+) levels have been observed in multiple lifestyle and age-related medical conditions. This has led to the hypothesis that dietary supplementation with NAD+ precursors, or vitamin B3s, could exert health benefits. Among the different molecules that can act as NAD+ precursors, Nicotinamid...
