Wakao, Shohei Oguma, Yo Kushida, Yoshihiro Kuroda, Yasumasa Tatsumi, Kazuki Dezawa, Mari
Published in
Cellular and Molecular Life Sciences
Stem cells undergo cytokine-driven differentiation, but this process often takes longer than several weeks to complete. A novel mechanism for somatic stem cell differentiation via phagocytosing ‘model cells’ (apoptotic differentiated cells) was found to require only a short time frame. Pluripotent-like Muse cells, multipotent mesenchymal stem cells...
Lemmens, Veerle Thevelein, Bart Vella, Yana Kankowski, Svenja Leonhard, Julia Mizuno, Hideaki Rocha, Susana Brône, Bert Meier, Jochen C. Hendrix, Jelle
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Published in
Cellular and Molecular Life Sciences
Glycine receptors (GlyRs) are ligand-gated pentameric chloride channels in the central nervous system. GlyR-α3 is a possible target for chronic pain treatment and temporal lobe epilepsy. Alternative splicing into K or L variants determines the subcellular fate and function of GlyR-α3, yet it remains to be shown whether its different splice variants...
Lee, Jungwhoi Kim, Eunsoo Chong, Kyuha Ryu, Seung-Wook Kim, Chungyeul Choi, Kyungsun Kim, Jae-Hoon Choi, Chulhee
Published in
Cellular and Molecular Life Sciences
Contact-based pericellular interactions play important roles in cancer progression via juxtacrine signaling pathways. The present study revealed that hypoxia-inducible factor-1α (HIF-1α), induced even in non-hypoxic conditions by cell-to-cell contact, was a critical cue responsible for the malignant characteristics of glioblastoma multiforme (GBM) ...
Montagna, Giulia Pani, Giuseppe Flinkman, Dani Cristofaro, Francesco Pascucci, Barbara Massimino, Luca Lamparelli, Luigi Antonio Fassina, Lorenzo James, Peter Coffey, Eleanor
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Published in
Cellular and Molecular Life Sciences
Microgravity-induced bone loss is a major concern for space travelers. Ground-based microgravity simulators are crucial to study the effect of microgravity exposure on biological systems and to address the limitations posed by restricted access to real space. In this work, for the first time, we adopt a multidisciplinary approach to characterize th...
Maeso-Alonso, Laura Alonso-Olivares, Hugo Martinez-Garcia, Nicole Lopez-Ferreras, Lorena Villoch-Fernandez, Javier Puente-Santamaria, Laura Colas-Algora, Natalia Fernandez-Corona, Alfonso Lorenzo-Marcos, Maria Elena Jimenez, Benilde
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Preservation of blood vessel integrity, which is critical for normal physiology and organ function, is controlled at multiple levels, including endothelial junctions. However, the mechanism that controls the adequate assembly of endothelial cell junctions is not fully defined. Here, we uncover TAp73 transcription factor as a vascular architect that...
Yan, Shuaifeng Kotschenreuther, Konstantin Deng, Shuya Kofler, David M.
Published in
Cellular and Molecular Life Sciences
Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the joints but also leads to systemic inflammation. Auto-reactivity and dysregulation of self-tolerance are thought to play a vital role in disease onset. In the pathogenesis of autoimmune diseases, disturbed immunosuppressive properties of regulatory T cells contribute to the d...
Lou, Bingsheng Zeng, Lei Gao, Xinbo Qian, Xiaobing Li, Jing Jing Gu, Xinyu Liu, Zheng Liu, Keli Chen, Xun Lin, Xiaofeng
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Published in
Cellular and molecular life sciences : CMLS
The ciliary body critically contributes to the ocular physiology with multiple responsibilities in the production of aqueous humor, vision accommodation and intraocular immunity. Comparatively little work, however, has revealed the single-cell molecular taxonomy of the human ciliary body required for studying these functionalities. In this study, w...
Delle Vedove, Andrea Natarajan, Janani Zanni, Ginevra Eckenweiler, Matthias Muiños-Bühl, Anixa Storbeck, Markus Guillén Boixet, Jordina Barresi, Sabina Pizzi, Simone Hölker, Irmgard
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Published in
Cellular and molecular life sciences : CMLS
CAPRIN1 is a ubiquitously expressed protein, abundant in the brain, where it regulates the transport and translation of mRNAs of genes involved in synaptic plasticity. Here we describe two unrelated children, who developed early-onset ataxia, dysarthria, cognitive decline and muscle weakness. Trio exome sequencing unraveled the identical de novo c....
Diéguez-Martínez, Nora Espinosa-Gil, Sergio Yoldi, Guillermo Megías-Roda, Elisabet Bolinaga-Ayala, Idoia Viñas-Casas, Maria Gorgisen, Gokhan Domingo-Ortí, Inés Pérez-Montoyo, Héctor Bayascas, Jose R.
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Published in
Cellular and Molecular Life Sciences
Endometrial cancer (EC) is the most common type of gynecologic cancer in women of developed countries. Despite surgery combined with chemo-/radiotherapy regimens, overall survival of patients with high-risk EC tumors is poor, indicating a need for novel therapies. The MEK5-ERK5 pathway is activated in response to growth factors and to different str...
Ming, Zhenhua Vining, Brittany Bagheri-Fam, Stefan Harley, Vincent
Published in
Cellular and Molecular Life Sciences
The transcription factor SOX9 is essential for the development of multiple organs including bone, testis, heart, lung, pancreas, intestine and nervous system. Mutations in the human SOX9 gene led to campomelic dysplasia, a haploinsufficiency disorder with several skeletal malformations frequently accompanied by 46, XY sex reversal. The mechanisms u...
