Cao, Thong M. King, Michael R.
Published in
Cellular and Molecular Bioengineering
Introduction E-selectin is a member of the selectin family of cell adhesion molecules expressed on the plasma membrane of inflamed endothelium and facilitates initial leukocyte tethering and subsequent cell rolling during the early stages of the inflammatory response via binding to glycoproteins expressing sialyl LewisX and sialyl LewisA (sLeX/A). ...
Acquah, Caleb Jeevanandam, Jaison Tan, Kei Xian Danquah, Michael K.
Published in
Cellular and Molecular Bioengineering
Introduction The 2019-novel coronavirus disease (COVID-19) is an intractable global health challenge resulting in an aberrant rate of morbidity and mortality worldwide. The mode of entry for SARS-CoV-2 into host cells occurs through clathrin-mediated endocytosis. As part of the efforts to mitigate COVID-19 infections, rapid and accurate detection m...
Besser, Rachel R. Bowles, Annie C. Alassaf, Ahmad Carbonero, Daniel Maciel, Renata Saporta, Mario Agarwal, Ashutosh
Published in
Cellular and Molecular Bioengineering
Alagumuthu, Manikandan Rajpoot, Sajjan Baig, Mirza S.
Published in
Cellular and Molecular Bioengineering
Purpose SARS-CoV-2 is a SARS-like novel coronavirus strain first identified in December 2019 in Wuhan, China. The virus has since spread globally, resulting in the current ongoing coronavirus disease 19 (COVID-19) pandemic. SARS-CoV-2 spike protein is a critical factor in the COVID-19 pathogenesis via interactions with the host cell angiotensin-con...
Kadekar, Sandeep Barbe, Laurent Stoddart, Martin Varghese, Oommen P. Tenje, Maria Mestres, Gemma
Published in
Cellular and Molecular Bioengineering
Introduction Human mesenchymal stem cells (hMSCs) have a great clinical potential for tissue regeneration purposes due to its multilineage capability. Previous studies have reported that a single addition of 5-azacytidine (5-AzaC) causes the differentiation of hMSCs towards a myocardial lineage. The aim of this work was to evaluate the effect of 5-...
Mortlock, Ryland D. Georgia, Senta K. Finley, Stacey D.
Published in
Cellular and Molecular Bioengineering
Introduction The expansion of insulin-producing beta cells during pregnancy is critical to maintain glucose homeostasis in the face of increasing insulin resistance. Prolactin receptor (PRLR) signaling is one of the primary mediators of beta cell expansion during pregnancy, and loss of PRLR signaling results in reduced beta cell mass and gestationa...
Ryan, Holly Simmons, Chelsey S.
Published in
Cellular and Molecular Bioengineering
The kidneys are susceptible to adverse effects from many diseases, including several that are not tissue-specific. Acute kidney injury is a common complication of systemic diseases such as diabetes, lupus, and certain infections including the novel coronavirus (SARS-CoV-2). Microfluidic devices are an attractive option for disease modeling, offerin...
Simmons, Chelsey S McCarty, Owen J T Tripathi, Anubhav
Published in
Cellular and molecular bioengineering
Tymm, Carly Zhou, Junhu Tadimety, Amogha Burklund, Alison Zhang, John X J
Published in
Cellular and molecular bioengineering
The emergence of a novel coronavirus, SARS-CoV-2, has highlighted the need for rapid, accurate, and point-of-care diagnostic testing. As of now, there is not enough testing capacity in the world to meet the stated testing targets, which are expected to skyrocket globally for broader testing during reopening. This review focuses on the development o...
Lakshmanan, Hari Hara Sudhan Pore, Adity A Kohs, Tia C L Yazar, Feyza Thompson, Rachel M Jurney, Patrick L Maddala, Jeevan Olson, Sven R Shatzel, Joseph J Vanapalli, Siva A
...
Published in
Cellular and molecular bioengineering
Interventions that could prevent thrombosis, clinical decompensation, and respiratory compromise in patients with novel coronavirus disease (COVID-19) are key to decrease mortality rate. Studies show that profound cytokine release and excessive activation of blood coagulation appear to be key drivers of COVID-19 associated mortality. Since limited ...
