Freda, Christopher Thor Yin, Wei Ghebrehiwet, Berhane Rubenstein, David A.
Published in
Cellular and Molecular Bioengineering
Introduction We have experienced a pandemic induced by the interaction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) structural proteins with innate structures. These interactions are especially prevalent for patients with underlying pathologies, such as cardiovascular diseases. However, there has been limited work to uncover the ...
Udourioh, Godwin A. Solomon, Moses M. Epelle, Emmanuel I.
Published in
Cellular and Molecular Bioengineering
The novel coronavirus disease (COVID-19) pandemic outbreak is the most startling public health crises with attendant global socio-economic burden ever experienced in the twenty-first century. The level of devastation by this outbreak is such that highly impacted countries will take years to recover. Studies have shown that timely detection based on...
Steadman, Elisabeth Fandaros, Marina Yin, Wei
Published in
Cellular and Molecular Bioengineering
Hypercoagulability has emerged as a prominent consequence of COVID-19. This presents challenges not only in the clinic, but also in thrombosis research. Health and safety considerations, the status of the blood and plasma supply, the infection status of individual donors, and the mechanisms by which SARS-CoV-2 activates coagulation are all of conce...
Rikard, S. Michaela Myers, Paul J. Almquist, Joachim Gennemark, Peter Bruce, Anthony C. Wågberg, Maria Fritsche-Danielson, Regina Hansson, Kenny M. Lazzara, Matthew J. Peirce, Shayn M.
...
Introduction Pharmacologic approaches for promoting angiogenesis have been utilized to accelerate healing of chronic wounds in diabetic patients with varying degrees of success. We hypothesize that the distribution of proangiogenic drugs in the wound area critically impacts the rate of closure of diabetic wounds. To evaluate this hypothesis, we dev...
Dai, Guohao Feinberg, Adam W. Wan, Leo Q.
Published in
Cellular and Molecular Bioengineering
In January of 2020, the Biomedical Engineering Society (BMES)- Cellular and Molecular Bioengineering (CMBE) conference was held in Puerto Rico and themed “Vision 2020: Emerging Technologies to Elucidate the Rule of Life.” The annual BME-CMBE conference gathered worldwide leaders and discussed successes and challenges in engineering biological syste...
Cao, Thong M. King, Michael R.
Published in
Cellular and Molecular Bioengineering
Introduction E-selectin is a member of the selectin family of cell adhesion molecules expressed on the plasma membrane of inflamed endothelium and facilitates initial leukocyte tethering and subsequent cell rolling during the early stages of the inflammatory response via binding to glycoproteins expressing sialyl LewisX and sialyl LewisA (sLeX/A). ...
Acquah, Caleb Jeevanandam, Jaison Tan, Kei Xian Danquah, Michael K.
Published in
Cellular and Molecular Bioengineering
Introduction The 2019-novel coronavirus disease (COVID-19) is an intractable global health challenge resulting in an aberrant rate of morbidity and mortality worldwide. The mode of entry for SARS-CoV-2 into host cells occurs through clathrin-mediated endocytosis. As part of the efforts to mitigate COVID-19 infections, rapid and accurate detection m...
Kadekar, Sandeep Barbe, Laurent Stoddart, Martin Varghese, Oommen P. Tenje, Maria Mestres, Gemma
Introduction: Human mesenchymal stem cells (hMSCs) have a great clinical potential for tissue regeneration purposes due to its multilineage capability. Previous studies have reported that a single addition of 5-azacytidine (5-AzaC) causes the differentiation of hMSCs towards a myocardial lineage. The aim of this work was to evaluate the effect of 5...
Besser, Rachel R. Bowles, Annie C. Alassaf, Ahmad Carbonero, Daniel Maciel, Renata Saporta, Mario Agarwal, Ashutosh
Published in
Cellular and Molecular Bioengineering
Alagumuthu, Manikandan Rajpoot, Sajjan Baig, Mirza S.
Published in
Cellular and Molecular Bioengineering
Purpose SARS-CoV-2 is a SARS-like novel coronavirus strain first identified in December 2019 in Wuhan, China. The virus has since spread globally, resulting in the current ongoing coronavirus disease 19 (COVID-19) pandemic. SARS-CoV-2 spike protein is a critical factor in the COVID-19 pathogenesis via interactions with the host cell angiotensin-con...
