Wei, Yu-Miao Li, Xiang Xu, Ming Abais, Justine M. Chen, Yang Riebling, Christopher R. Boini, Krishna M. Li, Pin-Lan Zhang, Yang
Published in
Cellular Physiology and Biochemistry
Background/Aims: In addition to their action of lowering blood cholesterol levels, statins modulate biological characteristics and functions of arterial myocytes such as viability, proliferation, apoptosis, survival and contraction. The present study tested whether simvastatin, as a prototype statin, enhances autophagy in coronary arterial myocytes...
Li, Chao Bu, Juyuan Liao, Yifeng Zhang, Jin Han, Jun Zhang, Han Xing, Hao Li, Zhenli Wu, Han Liang, Lei
...
Published in
Cellular Physiology and Biochemistry
Background/Aims: Cullin 4A (CUL4A) is vital in cell survival, development, growth and cell cycle, it plays an important role in chaperone-mediated ubiquitination and interacts with TP53 in carcinogenesis. However, the clinicopathologic significance of CUL4A expression in colorectal cancer is unknown; in particular, the prognostic value of CUL4A com...
Hu, Shousen Yuan, Yongliang Song, Zhizhen Yan, Dan Kong, Xiangzhen
Published in
Cellular Physiology and Biochemistry
Background/Aims: Drug resistance remains a main obstacle to the treatment of non- small cell lung cancer (NSCLC). The aim of this study was to identify the expression profiles of microRNAs (miRNAs) in drug-resistant NSCLC cell lines. Methods: The expression profiles of miRNAs in drug-resistant NSCLC cell lines were examined using miRNA sequencing, ...
Zhang, Chuanhai Wang, Jing Jing He, Xiaoyun Wang, Chao Zhang, Boyang Xu, Jia Xu, Wentao Luo, Yunbo Huang, Kunlun
Published in
Cellular Physiology and Biochemistry
Background/Aims: Brown and beige adipocytes are widely recognized as potential therapeutic targets to treat obesity and related metabolic disorders, and the recruitment of brown and beige adipocytes is an essential aspect that requires attention. Although many methods of activating brown adipocytes or generating beige adipocytes have been reported,...
Liang, Ying-Chun Wu, Yu-Peng Chen, Dong-Ning Chen, Shao-Hao Li, Xiao-Dong Sun, Xiong-Lin Wei, Yong Ning, Xu Xue, Xue-Yi
Published in
Cellular Physiology and Biochemistry
Background/Aims: Accumulating evidence has shown that long non-coding RNAs (lncRNAs) in competing endogenous RNA (ceRNA) networks play crucial roles in tumor survival and patient prognosis; however, studies investigating ceRNA networks in pheochromocytoma (PCC) are lacking. In this study, we investigated the pathogenesis of PCC and whether lncRNAs ...
Lang, Lei Hou, Yixuan Chen, Yanlin Tu, Gang Tao, Jing Yang, Dan Xi, Lei Fu, Lixin Sun, Kexin Yin, Jiali
...
Published in
Cellular Physiology and Biochemistry
Background/Aims: The ataxia-telangiectasia mutated (ATM) protein kinase is critical for the maintenance of genomic stability and acts as tumor suppressor. Although evidence shows that a DNA damage-independent ATM (oxidized ATM) may be involved in cancer progression, the underlying mechanism is still unclear. Methods: Immunohistochemistry, immunoflu...
Shen, Jing Cao, Shoubo Sun, Xin Pan, Bo Cao, Jingyan Che, Dehai Jin, Shi Cao, Yingyue Tian, Ye Yu, Yan
...
Published in
Cellular Physiology and Biochemistry
Background/Aims: Sonodynamic therapy (SDT) is expected to be a new method to solve the clinical problems caused by advanced metastasis in patients with lung cancer. The use of ultrasound has the advantage of being noninvasive, with deep-penetration properties. This study explored the anti-tumor effect of SDT with a new sonosensitizer, sinoporphyrin...
Choi, Seok Kang, Hyun Goo Wu, Mei Jin Jiao, Han Yi Shin, Dong Hoon Hong, Chansik Jun, Jae Yeoul
Published in
Cellular Physiology and Biochemistry
Background/Aims: Anoctamin1 (Ca2+-activated Cl- channel, ANO1) is a specific marker of the interstitial cells of Cajal (ICC) in the gastrointestinal tract, and are candidate proteins that can function as pacemaker channels. Recently, novel selective ANO1 inhibitors were discovered and used to study Ca2+-activated Cl- channels. Therefore, to investi...
Yu, Yanan Shinohara, Kyosuke Xu, Huanming Li, Zhenfeng Nishida, Tomoki Hamada, Hiroshi Xu, Yuanqing Zhou, Jingqi Shao, Daisy Li, Xiangchen
...
Published in
Cellular Physiology and Biochemistry
Background/Aims: Nodal cilia that rotate in the ventral node play an important role in establishing left-right asymmetry during embryogenesis; however, inv mutant cilia present abnormal movement and induce laterality defects. The mechanism of their motility, which is regulated by dynein activation and microtubule arrangement, has not been fully und...
Song, Shuling Tan, Jin Miao, Yuyang Sun, Zuoming Zhang, Qiang
Published in
Cellular Physiology and Biochemistry
Background/Aims: Intermittent hypoxia (IH) causes apoptosis in pancreatic β-cells, but the potential mechanisms remain unclear. Endoplasmic reticulum (ER) stress, autophagy, and apoptosis are interlocked in an extensive crosstalk. Thus, this study aimed to investigate the contributions of ER stress and autophagy to IH-induced pancreatic β-cell apop...
