Pol, Erwan Côme, Etienne Merlaud, Zaha Gouhier, Juliette Russeau, Marion Scotto-Lomassese, Sophie Moutkine, Imane Marques, Xavier Lévi, Sabine
Published in
Cells
Na-K-2Cl cotransporter 1 (NKCC1) regulates chloride influx in neurons and thereby GABAA receptor activity in normal and pathological conditions. Here, we characterized in hippocampal neurons the membrane expression, distribution and dynamics of exogenous NKCC1a and NKCC1b isoforms and compared them to those of the chloride extruder K-Cl cotransport...
Allegra, Alessandro Caserta, Santino Mirabile, Giuseppe Gangemi, Sebastiano
Published in
Cells
One of the traits of cancer cells is abnormal DNA methylation patterns. The idea that age-related epigenetic changes may partially explain the increased risk of cancer in the elderly is based on the observation that aging is also accompanied by comparable changes in epigenetic patterns. Lineage bias and decreased stem cell function are signs of hem...
Teichmann, Elisa Blessing, Elane Hinz, Burkhard
Published in
Cells
Atherosclerosis is associated with vascular smooth muscle cell proliferation, chronic vascular inflammation, and leukocyte adhesion. In view of the cardioprotective effects of cannabinoids described in recent years, the present study investigated the impact of the non-psychoactive phytocannabinoids cannabidiol (CBD) and tetrahydrocannabivarin (THCV...
Miceska, Simona Škof, Erik Gašljević, Gorana Kloboves-Prevodnik, Veronika
Published in
Cells
Tumor spheroids in the ascites of high-grade serous carcinoma (HGSC) are poorly described. Our objective was to describe their morphological features, cellular composition, PD-1 and PD-L1 expression, and survival correlation of these parameters. The density and size of spheroids were assessed in Giemsa-stained smears; the cell composition of sphero...
Li, Shanshan Zhu, Haodong He, Ying Hong, Ni Wang, Guoping Wang, Liping
Published in
Cells
Pear ring rot disease is an important branch disease, caused by Botryosphaeria dothidea. With the discovery of fungal viruses, the use of their attenuated properties for biological control provides a new strategy for the biological control of fungal disease. RNA silencing is a major antiviral defense mechanism in plants, insects, and fungi. Viruses...
Duperray, Maëlle Hardet, Fanny Henriet, Elodie Saint-Marc, Christelle Boué-Grabot, Eric Daignan-Fornier, Bertrand Massé, Karine Pinson, Benoît
Published in
Cells
Purines are required for fundamental biological processes and alterations in their metabolism lead to severe genetic diseases associated with developmental defects whose etiology remains unclear. Here, we studied the developmental requirements for purine metabolism using the amphibian Xenopus laevis as a vertebrate model. We provide the first funct...
Chu, Erskine Mychasiuk, Richelle Tsantikos, Evelyn Raftery, April L L'Estrange-Stranieri, Elan Dill, Larissa K Semple, Bridgette D Hibbs, Margaret L
Published in
Cells
Chronic neuroinflammation and glial activation are associated with the development of many neurodegenerative diseases and neuropsychological disorders. Recent evidence suggests that the protein tyrosine kinase Lyn and the lipid phosphatase SH2 domain-containing inositol 5' phosphatase-1 (SHIP-1) regulate neuroimmunological responses, but their home...
Blaskovic, Sanja Anagnostopoulou, Pinelopi Borisova, Elena Schittny, Dominik Donati, Yves Haberthür, David Zhou-Suckow, Zhe Mall, Marcus A Schlepütz, Christian M Stampanoni, Marco
...
Published in
Cells
(1) Background: Stereological estimations significantly contributed to our understanding of lung anatomy and physiology. Taking stereology fully 3-dimensional facilitates the estimation of novel parameters. (2) Methods: We developed a protocol for the analysis of all airspaces of an entire lung. It includes (i) high-resolution synchrotron radiation...
Przybylla, Randy Krohn, Mathias Sellin, Marie-Luise Frank, Marcus Oswald, Stefan Linnebacher, Michael
Published in
Cells
The most common in vitro model for absorption, distribution, metabolism, and excretion (ADME) purposes is currently the Caco-2 cell line. However, clear differences in gene and protein expression towards the small intestine and an, at best, fair prediction accuracy of intestinal drug absorption restrict the usefulness of a model for intestinal epit...
Starodubtseva, Maria N Shkliarava, Nastassia M Chelnokova, Irina A Villalba, María I Krylov, Andrei Yu Nadyrov, Eldar A Kasas, Sandor
Published in
Cells
Cells of two molecular genetic types of breast cancer-hormone-dependent breast cancer (ZR-75 cell line) and triple-negative breast cancer (BT-20 cell line)-were studied using atomic force microscopy and an optical nanomotion detection method. Using the Peak Force QNM and Force Volume AFM modes, we revealed the unique patterns of the dependence of Y...
