Santo, Stefano Di Seiler, Stefanie Guzman, Raphael Widmer, Hans Rudolf
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Cell transplantation
There is substantial evidence that stem and progenitor cells secrete trophic factors that have potential for repairing injured tissues. We have previously reported that the conditioned medium (CM) obtained from endothelial progenitor cells (EPC) cultures protects striatal neurons against 3-nitropropionic acid-induced toxicity. In the present study ...
Dong, Ping Zhang, Ying Yan, Dong-Yong Wang, Yi Xu, Xiu Zhao, Ying-Chun Xiao, Tian-Tian
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Cell transplantation
Breastfeeding has been shown to have a protective effect on the occurrence of necrotizing enterocolitis (NEC), but the mechanism remains unclear. In the context of NEC pathogenesis, many of the protective properties of exosomes on the intestinal epithelial compartment make it an ideal therapeutic target. In the present study, our hypothesis was tha...
Lee, Jea-Young Castelli, Vanessa Bonsack, Brooke García-Sánchez, Julián Kingsbury, Chase Nguyen, Hung Tajiri, Naoki Borlongan, Cesar V
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Cell transplantation
Middle cerebral artery occlusion in rodents remains a widely used model of ischemic stroke. Recently, we reported the occurrence of retinal ischemia in animals subjected to middle cerebral artery occlusion, owing in part to the circulatory juxtaposition of the ophthalmic artery to the middle cerebral artery. In this study, we examined the eye hemod...
Zhu, Guan Qun Jeon, Seung Hwan Lee, Kyu Won Cho, Hyuk Jin Ha, U-Syn Hong, Sung-Hoo Lee, Ji Youl Kwon, Eun Bi Kim, Hyo-Jin Lee, Soon Min
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Published in
Cell transplantation
There is still a lack of sufficient research on the mechanism behind neurogenic bladder (NB) treatment. The aim of this study was to explore the effect of overexpressed stromal cell-derived factor-1 (SDF-1) secreted by engineered immortalized mesenchymal stem cells (imMSCs) on the NB. In this study, primary bone marrow mesenchymal stem cells (BM-MS...
Han, Wei Yu, Fan Cao, Jiachao Dong, Bo Guan, Wei Shi, Jia
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Cell transplantation
Glioma is the most common malignant tumor in the central nervous system with a poor median survival. Valproic acid (VPA), a widely used antiepileptic drug, has been found to have antitumor effects on gliomas, but its role still has not been determined. In this study, we investigated VPA-induced apoptotic and autophagic effects on human U251 and SNB...
Yurie, Hirofumi Ikeguchi, Ryosuke Aoyama, Tomoki Tanaka, Mai Oda, Hiroki Takeuchi, Hisataka Mitsuzawa, Sadaki Ando, Maki Yoshimoto, Koichi Noguchi, Takashi
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Cell transplantation
We previously reported that a nerve conduit created from fibroblasts promotes nerve regeneration in a rat sciatic nerve model. This study aims to determine whether a nerve conduit created from bone marrow stromal cells (BMSCs) can promote nerve regeneration. Primary BMSCs were isolated from femur bone marrow of two Lewis rats, and cells at passages...
Jiang, Xueping Gao, Yanping Zhang, Nannan Yuan, Cheng Luo, Yuan Sun, Wenjie Zhang, Jianguo Ren, Jiangbo Gong, Yan Xie, Conghua
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Cell transplantation
Tumor microenvironment (TME) has critical impacts on the pathogenesis of lung adenocarcinoma (LUAD). However, the molecular mechanism of TME effects on the prognosis of LUAD patients remains unclear. Our study aimed to establish an immune-related gene pair (IRGP) model for prognosis prediction and internal mechanism investigation. Based on 702 TME-...
Chen, Kuan-Hung Shao, Pei-Lin Li, Yi-Chen Chiang, John Y Sung, Pei-Hsun Chien, Hui-Wen Shih, Fu-Yuan Lee, Mel S Chen, Wu-Fu Yip, Hon-Kan
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Published in
Cell transplantation
Intracranial hemorrhage from stroke and head trauma elicits a cascade of inflammatory and immune reactions detrimental to neurological integrity and function at cellular and molecular levels. This study tested the hypothesis that human umbilical cord-derived mesenchymal stem cell (HUCDMSC) therapy effectively protected the brain integrity and neuro...
Singh, Deepti Dromel, Pierre C Perepelkina, Tatiana Baranov, Petr Young, Michael
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Cell transplantation
The optic pathway glioma (OPG) is a slow-growing brain tumor that arises along the optic nerve or its downstream connections and causing vision to gradually worsen with time. This tumor forms in children with a genetic condition called neurofibromatosis type 1 (NF1), causing tumors to grow on nerves. In normal conditions, glial cells are there to s...
Olack, Barbara J Alexander, Michael Swanson, Carol J Kilburn, Julie Corrales, Nicole Flores, Antonio Heng, Jennifer Arulmoli, Jayagowri Omori, Keiko Chlebeck, Peter J
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Cell transplantation
Access to functional high-quality pancreatic human islets is critical to advance diabetes research. The Integrated Islet Distribution Program (IIDP), a major source for human islet distribution for over 15 years, conducted a study to evaluate the most advantageous times to ship islets postisolation to maximize islet recovery. For the evaluation, th...
