Cao, Yunlong Jian, Fanchong Zhang, Zhiying Yisimayi, Ayijiang Hao, Xiaohua Bao, Linlin Yuan, Fei Yu, Yuanling Du, Shuo Wang, Jing
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Published in
Cell reports
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages have escaped most receptor-binding domain (RBD)-targeting therapeutic neutralizing antibodies (NAbs), which proves that previous NAb drug screening strategies are deficient against the fast-evolving SARS-CoV-2. Better broad NAb drug candidate selection methods are need...
Furth-Lavi, Judith Hija, Ayat Tornovsky-Babeay, Sharona Mazouz, Adi Dahan, Tehila Stolovich-Rain, Miri Klochendler, Agnes Dor, Yuval Avrahami, Dana Glaser, Benjamin
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Published in
Cell reports
Diabetogenic ablation of beta cells in mice triggers a regenerative response whereby surviving beta cells proliferate and euglycemia is regained. Here, we identify and characterize heterogeneity in response to beta cell ablation. Efficient beta cell elimination leading to severe hyperglycemia (>28 mmol/L), causes permanent diabetes with failed rege...
Jia, Yunfei Niu, Sheng Hu, Yu Chai, Yan Zheng, Anqi Su, Chao Wu, Lili Han, Pengcheng Han, Pu Lu, Dan
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Published in
Cell reports
Since the identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, multiple SARS-CoV-2-related viruses have been characterized, including pangolin-origin GD/1/2019 and GX/P2V/2017. Our previous study indicated that both viruses have the potential to infect humans. Here, we find that CB6 (com...
Ash, Michelle K Bhimalli, Pavan P Cho, Byoung-Kyu Mattamana, Basil Baby Gambut, Stéphanie Tarhoni, Imad Fhied, Cristina L Reyes, Anjelica F Welninski, Samantha J Arivalagan, Jaison
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Published in
Cell reports
Although vaccination efforts have expanded, there are still gaps in our understanding surrounding the immune response to SARS-CoV-2. Measuring IgG Fc glycosylation provides insight into an infected individual's inflammatory state, among other functions. We set out to interrogate bulk IgG glycosylation changes from SARS-CoV-2 infection and vaccinati...
Chang, Charles A Bhagchandani, Preksha Poyser, Jessica Velasco, Brenda J Zhao, Weichen Kwon, Hye-Sook Meyer, Everett Shizuru, Judith A Kim, Seung K
Published in
Cell reports
Mixed hematopoietic chimerism can promote immune tolerance of donor-matched transplanted tissues, like pancreatic islets. However, adoption of this strategy is limited by the toxicity of standard treatments that enable donor hematopoietic cell engraftment. Here, we address these concerns with a non-myeloablative conditioning regimen that enables he...
McNamara, Colin G Rothwell, Max Sharott, Andrew
Published in
Cell reports
Closed-loop interaction has the potential to regulate ongoing brain activity by continuously binding an external stimulation to specific dynamics of a neural circuit. Achieving interactive modulation requires a stable brain-machine feedback loop. Here, we demonstrate that it is possible to maintain oscillatory brain activity in a desired state by d...
Bates, Timothy A Lu, Pei Kang, Ye Jin Schoen, Devin Thornton, Micah McBride, Savannah K Park, Chanhee Kim, Daehwan Messer, William B Curlin, Marcel E
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Published in
Cell reports
Each severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant renews concerns about decreased vaccine neutralization weakening efficacy. However, while prevention of infection varies, protection from disease remains and implicates immunity beyond neutralization in vaccine efficacy. Polyclonal antibodies function through Fab domains that...
Tubiana, Jérôme Xiang, Yufei Fan, Li Wolfson, Haim J Chen, Kong Schneidman-Duhovny, Dina Shi, Yi
Published in
Cell reports
The SARS-CoV-2 Omicron variant evades most neutralizing vaccine-induced antibodies and is associated with lower antibody titers upon breakthrough infections than previous variants. However, the mechanism remains unclear. Here, we find using a geometric deep-learning model that Omicron's extensively mutated receptor binding site (RBS) features reduc...
Magnotti, Flora Chirita, Daria Dalmon, Sarah Martin, Amandine Bronnec, Pauline Sousa, Jeremy Helynck, Olivier Lee, Wonyong Kastner, Daniel L Chae, Jae Jin
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Published in
Cell reports
The pyrin inflammasome acts as a guard of RhoA GTPases and is central to immune defenses against RhoA-manipulating pathogens. Pyrin activation proceeds in two steps. Yet, the second step is still poorly understood. Using cells constitutively activated for the pyrin step 1, a chemical screen identifies etiocholanolone and pregnanolone, two catabolit...
Webster, Amy K Chitrakar, Rojin Taylor, Seth M Baugh, L Ryan
Published in
Cell reports
Nutrient availability governs growth and quiescence, and many animals arrest development when starved. Using C. elegans L1 arrest as a model, we show that gene expression changes deep into starvation. Surprisingly, relative expression of germline-enriched genes increases for days. We conditionally degrade the large subunit of RNA polymerase II usin...
