Zhang, Tianhua Wang, Yuzhen Yu, Hongjiu Zhang, Ting Guo, Lianying Xu, Jie Wei, Xiaoqing Wang, Ning Wu, Yingjie Wang, Xiuli
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Published in
Cell death & disease
Autophagy predominantly promotes cell survival by recycling cell components, while it kills cells in specific contexts. Cell death related to autophagy plays important roles in multiple physiological and pathological situations including tumorigenesis, and the mechanism needs to be defined further. PRAS40 was found to be crucial in various cancers,...
Zhao, Haiyang Zhao, Tingting Yang, Jihong Huang, Qianqian Wu, Hua Pan, Yueyun Wang, Hui Qian, Yun
Published in
Cell death & disease
Oxidative stress (OS) is one of the primary factors leading to male infertility. Oral administration of antioxidants has thus far been found to significantly improve the quality of human sperm. Therefore, antioxidant treatment has become the consensus among international experts on male infertility. In this study, peroxisomal biogenesis factor 3 (P...
Wang, Shu-Ping Wu, Shi-Qi Huang, Shi-Hui Tang, Yi-Xuan Meng, Liu-Qiong Liu, Feng Zhu, Qi-Hua Xu, Yun-Gen
Published in
Cell Death & Disease
Inducing homologous-recombination (HR) deficiency is an effective strategy to broaden the indications of PARP inhibitors in the treatment of triple-negative breast cancer (TNBC). Herein, we find that repression of the oncogenic transcription factor FOXM1 using FOXM1 shRNA or FOXM1 inhibitor FDI-6 can sensitize BRCA-proficient TNBC to PARP inhibitor...
Sönmez, Aynur Mustafa, Rasem Ryll, Salome T. Tuorto, Francesca Wacheul, Ludivine Ponti, Donatella Litke, Christian Hering, Tanja Kojer, Kerstin Koch, Jenniver
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Published in
Cell Death & Disease
Transcriptional and cellular-stress surveillance deficits are hallmarks of Huntington’s disease (HD), a fatal autosomal-dominant neurodegenerative disorder caused by a pathological expansion of CAG repeats in the Huntingtin (HTT) gene. The nucleolus, a dynamic nuclear biomolecular condensate and the site of ribosomal RNA (rRNA) transcription, is im...
Zhang, Ying Ma, Wenping Fan, Wenhua Ren, Changyuan Xu, Jianbao Zeng, Fan Bao, Zhaoshi Jiang, Tao Zhao, Zheng
Published in
Cell Death & Disease
Glioma is the most common primary malignant brain tumor with limited treatment options and poor prognosis. To investigate the potential relationships between transcriptional characteristics and clinical phenotypes, we applied weighted gene co-expression network analysis (WGCNA) to construct a free-scale gene co-expression network yielding four modu...
Zhong, Chenxi Chen, Ming Chen, Yu Yao, Feng Fang, Wentao
Published in
Cell Death & Disease
Aberrant activation of Wnt/β-catenin signaling and dysregulation of metabolism have been frequently observed in lung cancer. However, the molecular mechanism by which Wnt/β-catenin signaling is regulated and the link between Wnt/β-catenin signaling and cancer metabolism are not fully understood. In this study, we showed that the loss of dual serine...
He, Yuan Yue, HongQin Cheng, Ying Ding, Zhilong Xu, Zhen Lv, Chunyang Wang, Zheng Wang, Jing Yin, Chenglong Hao, Huihui
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Published in
Cell Death & Disease
Long noncoding RNAs (lncRNAs) are regarded as crucial regulators in tumor progression. Potassium two pore domain channel subfamily K member 15 and WISP2 antisense RNA 1 (KCNK15-AS1) has been confirmed to inhibit the migration and invasion of pancreatic cancer (PC) cells. However, its downstream mechanism and effect on other cellular functions in PC...
Chen, Xuejiao Wang, Ziyi Han, Sheng Wang, Zeng Zhang, Yu Li, Xiangdong Xia, Nan Yu, Wenjie Jia, Chenyang Ni, Yong
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Published in
Cell Death & Disease
Liver fibrosis is a danger signal indicating a huge risk of liver cancer occurrence, but there is still no effective clinical means to regulate the progress of liver fibrosis. Although a variety of drugs targeting SYK have been developed for tumors and autoimmune diseases, the mechanism and specific efficacy of SYK’s role in liver fibrosis are not ...
Yan, Ziqian Sheng, Zhimei Zheng, Yuanhang Feng, Ruijun Xiao, Qinpei Shi, Lihong Li, Hongli Yin, Chonggao Luo, Hao Hao, Chong
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Published in
Cell Death & Disease
Studies have shown that cancer-associated fibroblasts (CAFs) play an irreplaceable role in the occurrence and development of tumors. Therefore, exploring the action and mechanism of CAFs on tumor cells is particularly important. In this study, we compared the effects of CAFs-derived exosomes and normal fibroblasts (NFs)-derived exosomes on breast c...
Dai, Daofeng Yang, Yan Yu, Jieqing Dang, Tianfeng Qin, Wenjing Teng, Lisong Ye, Jing Jiang, Hongqun
Published in
Cell Death & Disease
The development and progression of gastric cancer (GC) is greatly influenced by gastric microbiota and their metabolites. Here, we characterized the gastric microbiome and metabolome profiles of 37 GC tumor tissues and matched non-tumor tissues using 16s rRNA gene sequencing and ultrahigh performance liquid chromatography tandem mass spectrometry, ...
