Chang, Rui-Min Fu, Yao Zeng, Jun Zhu, Xiao-Yan Gao, Yang
Published in
Cell death & disease
Cancer-derived exosomal miRNAs are implicated in tumorigenesis and development of lung adenocarcinoma (LUAD). The objective of this study is to unravel the biological function of exosomal miR-197-3p in LUAD metastasis. qRT-PCR showed that elevated miR-197-3p in LUAD tissues was positively correlated with LUAD metastasis. CCK-8, tube formation, tran...
Zhao, Bin Huang, Cong Pan, Jie Hu, Hao Liu, Xiaojuan Zhang, Kaoyuan Zhou, Fenli Shi, Xin Wu, Jun Yu, Bo
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Published in
Cell death & disease
Recent evidence has indicated that circular RNAs (circRNAs), a novel type of regulatory RNA, play important roles in the development and progression of various cancers. However, the potential regulatory roles and molecular mechanisms of circRNAs in clear cell renal cell carcinoma (ccRCC) remain largely unclear. Here, we explored circRNA expression ...
Sun, Xiaoli Ni, Yajie Lu, Qingmiao Liang, Yan Gu, Mengru Xue, Xian Dai, Chunsun
Published in
Cell death & disease
The cell-cell interaction between hepatocytes and Kupffer cells (KCs) is crucial for maintaining liver homeostasis, and the loss of KCs and hepatocytes is known to represent a common pathogenic phenomenon in autoimmune hepatitis. Until now, the mechanisms of cell-cell interaction between hepatocytes and KCs involved in immune-mediated hepatitis rem...
Branco, Laura Migliari Amaral, Marcelo Pires Boekhoff, Henning de Lima, Ana Beatriz Figueiredo Farias, Ingrid Sancho Lage, Silvia Lucena Pereira, Gustavo José Silva Franklin, Bernardo Simões Bortoluci, Karina Ramalho
Published in
Cell death & disease
The NAIP/NLRC4 inflammasome is classically associated with the detection of bacterial invasion to the cytosol. However, recent studies have demonstrated that NAIP/NLRC4 is also activated in non-bacterial infections, and in sterile inflammation. Moreover, in addition to the well-established model for the detection of bacterial proteins by NAIP prote...
Maciejewska, Natalia Olszewski, Mateusz Jurasz, Jakub Baginski, Maciej Stasevych, Maryna Zvarych, Viktor Folini, Marco Zaffaroni, Nadia
Published in
Cell death & disease
Telomerase reactivation is one of the hallmarks of cancer, which plays an important role in cellular immortalization and the development and progression of the tumor. Chemical telomerase inhibitors have been shown to trigger replicative senescence and apoptotic cell death both in vitro and in vivo. Due to its upregulation in various cancers, telome...
Yi, Chunyang He, Jiacheng Huang, Dan Zhao, Yumiao Zhang, Chan Ye, Xiyun Huang, Ying Nussinov, Ruth Zheng, Junke Liu, Mingyao
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Published in
Cell death & disease
Blocked cellular differentiation is a critical pathologic hallmark of acute myeloid leukemia (AML). Here, we showed that genetic activation of the orphan GPCR GPR132 significantly induced cell differentiation of AML both in vitro and in vivo, indicating that GPR132 is a potential trigger of myeloid differentiation. To explore the therapeutic potent...
Frappaolo, Anna Karimpour-Ghahnavieh, Angela Cesare, Giuliana Sechi, Stefano Fraschini, Roberta Vaccari, Thomas Giansanti, Maria Grazia
Published in
Cell death & disease
The oncoprotein GOLPH3 (Golgi phosphoprotein 3) is an evolutionarily conserved phosphatidylinositol 4-phosphate effector, mainly localized to the Golgi apparatus, where it supports organelle architecture and vesicular trafficking. Overexpression of human GOLPH3 correlates with poor prognosis in several cancer types and is associated with enhanced s...
Lim, Je Sun Shi, YuJie Park, Su Hwan Jeon, So Mi Zhang, Chuanbao Park, Yun-Yong Liu, Rui Li, Jing Cho, Wan-Seob Du, Linyong
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Published in
Cell death & disease
Glioblastoma (GBM) is a highly vascular malignant brain tumor that overexpresses vascular endothelial growth factor (VEGF) and phosphofructokinase 1 platelet isoform (PFKP), which catalyzes a rate-limiting reaction in glycolysis. However, whether PFKP and VEGF are reciprocally regulated during GBM tumor growth remains unknown. Here, we show that PF...
Mkrtchyan, Garik V Veviorskiy, Alexander Izumchenko, Evgeny Shneyderman, Anastasia Pun, Frank W Ozerov, Ivan V Aliper, Alex Zhavoronkov, Alex Scheibye-Knudsen, Morten
Published in
Cell death & disease
Multiple cancer types have limited targeted therapeutic options, in part due to incomplete understanding of the molecular processes underlying tumorigenesis and significant intra- and inter-tumor heterogeneity. Identification of novel molecular biomarkers stratifying cancer patients with different survival outcomes may provide new opportunities for...
Fan, Yipu Zhang, Yihan Shi, Kunyu Cheng, Shan Pei, Duanqing Shu, Xiaodong
Published in
Cell death & disease
Ferroptosis induced by detrimental accumulation of lipid peroxides has been recently linked to a variety of pathological conditions ranging from acute tissue injuries to chronic degenerative diseases and suppression of ferroptosis by small chemical inhibitors is beneficial to the prevention and treatment of these diseases. However, in vivo applicab...
