Pandey, Amita Yadav, Vipul Sharma, Aditi Khurana, Jitendra P Pandey, Girdhar K
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Cell adhesion & migration
The unc-53/NAV2 gene encodes for an adaptor protein required for cell migrations along the anteroposterior (AP) axes of C. elegans. This study identifies unc-53 as a novel component of signaling pathways regulating Distal tip cell (DTC) migrations along the AP and dorsoventral (DV) axes. unc-53 negatively regulates and functions downstream of ced-1...
Röselová, Pavla Obr, Adam Holoubek, Aleš Grebeňová, Dana Kuželová, Kateřina
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Cell adhesion & migration
Interaction of leukemia blasts with the bone marrow extracellular matrix often results in protection of leukemia cells from chemotherapy and in persistence of the residual disease which is on the basis of subsequent relapses. The adhesion signaling pathways have been extensively studied in adherent cells as well as in mature haematopoietic cells, b...
Sarabipour, Sarvenaz Mac Gabhann, Feilim
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Cell adhesion & migration
All known splice isoforms of vascular endothelial growth factor A (VEGF-A) can bind to the receptor tyrosine kinases VEGFR-1 and VEGFR-2. We focus here on VEGF-A121a and VEGF-A165a, two of the most abundant VEGF-A splice isoforms in human tissue 1 , and their ability to bind the Neuropilin co-receptors NRP1 and NRP2. The Neuropilins are key vascula...
Zhu, Hongyu Gao, Mingming Gao, Xiangdong Tong, Yue
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Cell adhesion & migration
Angiogenesis plays an important role in controlling tissue development and maintaining normal tissue function. Dysregulated angiogenesis is implicated in the pathogenesis of a variety of diseases, particularly diabetes, cancers, and neurodegenerative disorders. As the major regulator of angiogenesis, the vascular endothelial growth factor (VEGF) fa...
Li, Duo Liu, Ke Li, Zhiyong Wang, Jian Wang, Xiaofeng
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Cell adhesion & migration
Previous studies indicate that TGFBR3 (transforming growth factor type III receptor, also known as betaglycan), a novel suppressor of progression in certain cancers, is down-regulated in tongue squamous cell carcinoma (TSCC). However, the role of this factor as an upstream regulator in TSCC cells remains to be elucidated. The present study was desi...
Kapincharanon, Chompunoot Thongboonkerd, Visith
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Cell adhesion & migration
Hypokalemia is a common electrolyte disorder in hospitalized patients and those with chronic diseases and is associated with renal tubular injury. Our recent expression proteomics study revealed changes in levels of several proteins in renal tubular cells during K+ deficiency. However, functional significance and mechanisms underlying such changes ...
Rampichová, M Košt'áková Kuželová, E Filová, E Chvojka, J Šafka, J Pelcl, M Daňková, J Prosecká, E Buzgo, M Plencner, M
...
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Cell adhesion & migration
Additive manufacturing, also called 3D printing, is an effective method for preparing scaffolds with defined structure and porosity. The disadvantage of the technique is the excessive smoothness of the printed fibers, which does not support cell adhesion. In the present study, a 3D printed scaffold was combined with electrospun classic or structure...
Ceafalan, Laura Cristina Fertig, Tudor Emanuel Popescu, Alexandru Cristian Popescu, Bogdan Ovidiu Hinescu, Mihail Eugen Gherghiceanu, Mihaela
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Cell adhesion & migration
Regeneration in adult skeletal muscle relies on the activation, proliferation, and fusion of myogenic precursor cells (MPC), mostly resident satellite cells (SC). However, the regulatory mechanism during this process is still under evaluation, with the final aim to manipulate regeneration when the intrinsic mechanism is corrupted. Furthermore, inte...
Mendoza, Pablo A Silva, Patricio Díaz, Jorge Arriagada, Cecilia Canales, Jimena Cerda, Oscar Torres, Vicente A
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Cell adhesion & migration
The early endosome protein Rab5 was recently shown to promote cell migration by enhancing focal adhesion disassembly through mechanisms that remain elusive. Focal adhesion disassembly is associated to proteolysis of talin, in a process that requires calpain2. Since calpain2 has been found at vesicles and endosomal compartments, we hypothesized that...
Ambrogio, Chiara Darbo, Elodie Lee, Sam W Santamaría, David
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Cell adhesion & migration
The Discoidin Domain Receptor 1 (DDR1) receptor tyrosine kinase performs pleiotropic functions in the control of cell adhesion, proliferation, survival, migration, and invasion. Aberrant DDR1 function as a consequence of either mutations or increased expression has been associated with various human diseases including cancer. Pharmacological inhibi...
