Blondel, S Egesipe, A-L Picardi, P Jaskowiak, A-L Notarnicola, M Ragot, J Tournois, J Le Corf, A Brinon, B Poydenot, P
...
Published in
Cell Death and Disease
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by a dramatic appearance of premature aging. HGPS is due to a single-base substitution in exon 11 of the LMNA gene (c.1824C>T) leading to the production of a toxic form of the prelamin A protein called progerin. Because farnesylation process had been shown to contr...
Blondel, S Egesipe, A-L Picardi, P Jaskowiak, A-L Notarnicola, M Ragot, J Tournois, J Le Corf, A Brinon, B Poydenot, P
...
Published in
Cell Death and Disease
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by a dramatic appearance of premature aging. HGPS is due to a single-base substitution in exon 11 of the LMNA gene (c.1824C>T) leading to the production of a toxic form of the prelamin A protein called progerin. Because farnesylation process had been shown to contr...
Claudia Cerella Florian Muller Anthoula Gaigneaux Flavia Radogna Viry, Elodie Sébastien Chateauvieux Dicato, Mario Marc Diederich
Published in
Cell Death and Disease
Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na + /K +)-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extracted from the plant Calotropis pr...
Guo, W Liu, R Bhardwaj, G Yang, J C Changou, C Ma, A-H Mazloom, A Chintapalli, S Xiao, K Xiao, W
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Published in
Cell death & disease
Btk and Etk/BMX are Tec-family non-receptor tyrosine kinases. Btk has previously been reported to be expressed primarily in B cells and has an important role in immune responses and B-cell malignancies. Etk has been shown previously to provide a strong survival and metastasis signal in human prostate cancer cells, and to confer androgen independenc...
Mnich, K Carleton, L A Kavanagh, E T Doyle, K M Samali, A Gorman, A M
Published in
Cell death & disease
Nerve growth factor (NGF) is well characterised as an important pro-survival factor in neuronal cells that can inhibit apoptotic cell death upstream of mitochondrial outer membrane permeabilisation. Here we addressed the question of whether NGF can also protect against apoptosis downstream of caspase activation. NGF treatment promoted a rapid reduc...
Chimento, A Casaburi, I Bartucci, M Patrizii, M Dattilo, R Avena, P Andò, S Pezzi, V Sirianni, R
Published in
Cell death & disease
We have previously shown that estrogens binding to estrogen receptor (ER) α increase proliferation of Leydig tumor cells. Estrogens can also bind to G protein-coupled ER (GPER) and activation of this receptor can either increase or decrease cell proliferation of several tumor types. The aim of this study was to investigate GPER expression in R2C ra...
Badley, A D Sainski, A Wightman, F Lewin, S R
Published in
Cell death & disease
Recent cases of successful control of human immunodeficiency virus (HIV) by bone marrow transplant in combination with suppressive antiretroviral therapy (ART) and very early initiation of ART have provided proof of concept that HIV infection might now be cured. Current efforts focusing on gene therapy, boosting HIV-specific immunity, reducing infl...
Kono, K Mimura, K Kiessling, R
Published in
Cell death & disease
Chemoradiotherapy can induce immunogenic cell death, triggering danger signals such as high-mobility group box 1 protein, and resulting in T-cell immunity. This concept can potentially be harnessed for clinical therapy to enhance tumor-specific immunity. There is however limited information to translate this theory directly in a clinical setting. I...
Sachweh, M C C Drummond, C J Higgins, M Campbell, J Laín, S
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Cell death & disease
Nutlin-3 selectively activates p53 by inhibiting the interaction of this tumor suppressor with its negative regulator murine double minute 2 (mdm2), while trichostatin A (TSA) is one of the most potent histone deacetylase (HDAC) inhibitors currently available. As both Nutlin-3 and TSA increase the levels of the cell cycle inhibitor p21(cip1/waf1) i...
Tran, V H Bartolo, R Westphal, D Alsop, A Dewson, G Kluck, R M
Published in
Cell death & disease
During apoptosis, Bak and Bax permeabilize the mitochondrial outer membrane by undergoing major conformational change and oligomerization. This activation process in Bak is reported to require dephosphorylation of tyrosine-108 close to an activation trigger site. To investigate how dephosphorylation of Bak contributes to its activation and conforma...
