Yue, Tiantian Sun, Fei Wang, Faxi Yang, Chunliang Luo, Jiahui Rong, Shanjie Zhou, Haifeng Xiao, Jun Wang, Xiaohui Zhou, Qing
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Published in
Cell Death & Differentiation
The methyl-CpG-binding domain 2 (MBD2) interprets DNA methylome-encoded information through binding to the methylated CpG DNA, by which it regulates target gene expression at the transcriptional level. Although derailed DNA methylation has long been recognized to trigger or promote autoimmune responses in type 1 diabetes (T1D), the exact role of MB...
Gu, Linlin Surolia, Ranu Larson-Casey, Jennifer L. He, Chao Davis, Dana Kang, Jungsoon Antony, Veena B. Carter, A. Brent
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Cell Death & Differentiation
The mitochondrial calcium uniporter (MCU) regulates metabolic reprogramming in lung macrophages and the progression of pulmonary fibrosis. Fibrosis progression is associated with apoptosis resistance in lung macrophages; however, the mechanism(s) by which apoptosis resistance occurs is poorly understood. Here, we found a marked increase in mitochon...
Zaninello, Marta Palikaras, Konstantinos Sotiriou, Aggeliki Tavernarakis, Nektarios Scorrano, Luca
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Cell Death & Differentiation
Mitochondrial dysfunction and mitophagy are often hallmarks of neurodegenerative diseases such as autosomal dominant optic atrophy (ADOA) caused by mutations in the key mitochondrial dynamics protein optic atrophy 1 (Opa1). However, the second messengers linking mitochondrial dysfunction to initiation of mitophagy remain poorly characterized. Here,...
Lara-Chica, Maribel Correa-Sáez, Alejandro Jiménez-Izquierdo, Rafael Garrido-Rodríguez, Martín Ponce, Francisco J. Moreno, Rita Morrison, Kimberley Di Vona, Chiara Arató, Krisztina Jiménez-Jiménez, Carla
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Published in
Cell Death & Differentiation
The cell division cycle 25A (CDC25A) phosphatase is a key regulator of cell cycle progression that acts on the phosphorylation status of Cyclin–Cyclin-dependent kinase complexes, with an emergent role in the DNA damage response and cell survival control. The regulation of CDC25A activity and its protein level is essential to control the cell cycle ...
Yang, Kun Fan, Min Wang, Xiaohui Xu, Jingjing Wang, Yana Tu, Fei Gill, P. Spencer Ha, Tuanzhu Liu, Li Williams, David L.
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Published in
Cell Death & Differentiation
High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity and mortality of sepsis. However, it is unclear whether lactate could promote HMGB1 release during sepsis. The present study demonstrated a novel role of lactate in HMGB1 lactylation and acetylation in macrophages during polymicrobial sepsis. W...
Iennaco, Raffaele Formenti, Giulio Trovesi, Camilla Rossi, Riccardo Lorenzo Zuccato, Chiara Lischetti, Tiziana Bocchi, Vittoria Dickinson Scolz, Andrea Martínez-Labarga, Cristina Rickards, Olga
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Published in
Cell Death and Differentiation
Huntington’s disease is caused by a pathologically long (>35) CAG repeat located in the first exon of the Huntingtin gene ( HTT ). While pathologically expanded CAG repeats are the focus of extensive investigations, non-pathogenic CAG tracts in protein-coding genes are less well characterized. Here, we investigated the function and evolution of the...
Bizen, Norihisa Bepari, Asim K. Zhou, Li Abe, Manabu Sakimura, Kenji Ono, Katsuhiko Takebayashi, Hirohide
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Cell Death and Differentiation
Olig2 is indispensable for motoneuron and oligodendrocyte fate-specification in the pMN domain of embryonic spinal cords, and also involved in the proliferation and differentiation of several cell types in the nervous system, including neural progenitor cells (NPCs) and oligodendrocytes. However, how Olig2 controls these diverse biological processe...
Rufo, Nicole Korovesis, Dimitris Van Eygen, Sofie Derua, Rita Garg, Abhishek D. Finotello, Francesca Vara-Perez, Monica Rožanc, Jan Dewaele, Michael de Witte, Peter A.
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Published in
Cell Death & Differentiation
Mounting evidence indicates that immunogenic therapies engaging the unfolded protein response (UPR) following endoplasmic reticulum (ER) stress favor proficient cancer cell-immune interactions, by stimulating the release of immunomodulatory/proinflammatory factors by stressed or dying cancer cells. UPR-driven transcription of proinflammatory cytoki...
Rona, Gergely Zeke, Andras Miwatani-Minter, Bearach de Vries, Maren Kaur, Ramanjit Schinlever, Austin Garcia, Sheena Faye Goldberg, Hailey V. Wang, Hui Hinds, Thomas R.
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Published in
Cell Death and Differentiation
The risk of zoonotic coronavirus spillover into the human population, as highlighted by the SARS-CoV-2 pandemic, demands the development of pan-coronavirus antivirals. The efficacy of existing antiviral ribonucleoside/ribonucleotide analogs, such as remdesivir, is decreased by the viral proofreading exonuclease NSP14-NSP10 complex. Here, using a no...
Wang, Xin Ros, Uris Agrawal, Deepti Keller, Eva C. Slotta-Huspenina, Julia Dill, Veronika Shen, Bo Shi, Run Herold, Tobias Belka, Claus
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Published in
Cell Death & Differentiation
The blockade of cellular differentiation represents a hallmark of acute myeloid leukemia (AML), which is largely attributed to the dysfunction of lineage-specific transcription factors controlling cellular differentiation. However, alternative mechanisms of cellular differentiation programs in AML remain largely unexplored. Here we report that mixe...
