Published in Neuropsychobiology
Background: The results of studies examining the response to experimental pain during the menstrual cycle are conflicting because of differences in the definitions of the menstrual period, outcome measures and types of experimental pain stimulation. So far, there have been only a few studies correlating experimental pain with the levels of gonadal ...
Published in Cell
SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers – individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease...
Published in Cell
Researchers around the globe have been mounting, accelerating and redeploying efforts across disciplines and organizations to tackle the SARS CoV-2 outbreak. However, humankind continues to be afflicted by numerous other devastating diseases in increasing numbers. Here, we outline considerations and opportunities toward striking a good balance betw...
Published in Cell
A computational framework that allows for the identification and characterizaton of virus-infected cells as well as bystander cell responses reveals how SARS-CoV-2 alters the immune responses of patients.
Published in Cell
Using genomics and air travel information, the spread of SARS-CoV-2 in the United States from coast to coast is shown to be more a consequence of domestic introductions than of international travel.
Published in Cell
Using llamas immunized with prefusion-stabilized betacoronavirus spike proteins, Wrapp et al. identify neutralizing cross-reactive single-domain camelid antibodies, which may serve not only as useful reagents for researchers studying the viruses causing MERS, SARS, and COVID-19, but also potential therapeutic candidates. Crystal structures further ...
Published in Cell
Netea and colleagues argue that we may be able to prevent or decrease the severity of SARS-CoV-2 infection through certain clinically-approved live vaccines that “train” the innate immune system to be broadly vigilant against viral infection.
Published in Cell
Zhang et al. present an AI-based system, based on hundreds of thousands of human lung CT scan images, that can aid in distinguishing patients with pneumonia caused by SARS-CoV-2 versus other viral infections and can help to predict the prognosis of COVID-19 patients.
Published in Cell
Genomic and epidemiological analyses provide insights into how COVID-19 was contained in China’s most populous province using a combination of surveillance and travel restriction measures.
Published in Cell
Coronavirus disease 2019 (COVID-19) is a novel respiratory illness caused by SARS-CoV-2. Viral entry is mediated through viral spike protein and host ACE2 enzyme interaction. Most cases are mild; severe disease often involves cytokine storm and organ failure. Therapeutics including antivirals, immunomodulators, and vaccines are in development. To v...
