Ripin, Nina Parker, Roy
Published in
Cell
Ribonucleoprotein (RNP) granules are diverse membrane-less organelles that form through multivalent RNA-RNA, RNA-protein, and protein-protein interactions between RNPs. RNP granules are implicated in many aspects of RNA physiology, but in most cases their functions are poorly understood. RNP granules can be described through four key principles. Fi...
Lan, Zijun Song, Zihan Wang, Zhijuan Li, Ling Liu, Yiqun Zhi, Shuaihua Wang, Ruihan Wang, Jizong Li, Qiyun Bleckmann, Andrea
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Published in
Cell
Pollen-pistil interactions establish interspecific/intergeneric pre-zygotic hybridization barriers in plants. The rejection of undesired pollen at the stigma is crucial to avoid outcrossing but can be overcome with the support of mentor pollen. The mechanisms underlying this hybridization barrier are largely unknown. Here, in Arabidopsis, we demons...
Goring, Daphne R
Published in
Cell
Mate selection in flowering plants can occur very rapidly after male pollen contact on the female pistil, but the cellular regulators driving this process were poorly understood. In this issue of Cell, Lan et al. have discovered the components of a complex ligand-receptor system controlling pollen selection in Arabidopsis thaliana. Copyright © 2023...
Zimmerman, Ofer Zimmerman, Maxwell I Raju, Saravanan Nelson, Christopher A Errico, John M Madden, Emily A Holmes, Autumn C Hassan, Ahmed O VanBlargan, Laura A Kim, Arthur S
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Published in
Cell
MXRA8 is a receptor for chikungunya (CHIKV) and other arthritogenic alphaviruses with mammalian hosts. However, mammalian MXRA8 does not bind to alphaviruses that infect humans and have avian reservoirs. Here, we show that avian, but not mammalian, MXRA8 can act as a receptor for Sindbis, western equine encephalitis (WEEV), and related alphaviruses...
Bohlen, Jonathan Zhou, Qinhua Philippot, Quentin Ogishi, Masato Rinchai, Darawan Nieminen, Tea Seyedpour, Simin Parvaneh, Nima Rezaei, Nima Yazdanpanah, Niloufar
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Published in
Cell
Human inherited disorders of interferon-gamma (IFN-γ) immunity underlie severe mycobacterial diseases. We report X-linked recessive MCTS1 deficiency in men with mycobacterial disease from kindreds of different ancestries (from China, Finland, Iran, and Saudi Arabia). Complete deficiency of this translation re-initiation factor impairs the translati...
Watson, Joseph L Krüger, Lara K Ben-Sasson, Ariel J Bittleston, Alice Shahbazi, Marta N Planelles-Herrero, Vicente Jose Chambers, Joseph E Manton, James D Baker, David Derivery, Emmanuel
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Published in
Cell
Polarized cells rely on a polarized cytoskeleton to function. Yet, how cortical polarity cues induce cytoskeleton polarization remains elusive. Here, we capitalized on recently established designed 2D protein arrays to ectopically engineer cortical polarity of virtually any protein of interest during mitosis in various cell types. This enables dire...
Bakshi, Anand Iturra, Fabio Echegaray Alamban, Andrew Rosas-Salvans, Miquel Dumont, Sophie Aydogan, Mustafa G
Published in
Cell
Cytoplasmic divisions are thought to rely on nuclear divisions and mitotic signals. We demonstrate in Drosophila embryos that cytoplasm can divide repeatedly without nuclei and mitotic CDK/cyclin complexes. Cdk1 normally slows an otherwise faster cytoplasmic division cycle, coupling it with nuclear divisions, and when uncoupled, cytoplasm starts di...
Malawsky, Daniel S van Walree, Eva Jacobs, Benjamin M Heng, Teng Hiang Huang, Qin Qin Sabir, Ataf H Rahman, Saadia Sharif, Saghira Malik Khan, Ahsan Mirkov, Maša Umićević
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Published in
Cell
Autozygosity is associated with rare Mendelian disorders and clinically relevant quantitative traits. We investigated associations between the fraction of the genome in runs of homozygosity (FROH) and common diseases in Genes & Health (n = 23,978 British South Asians), UK Biobank (n = 397,184), and 23andMe. We show that restricting analysis to offs...
Dileep, Vishnu Boix, Carles A Mathys, Hansruedi Marco, Asaf Welch, Gwyneth M Meharena, Hiruy S Loon, Anjanet Jeloka, Ritika Peng, Zhuyu Bennett, David A
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Published in
Cell
Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark of neurodegenerative diseases including Alzheimer's disease (AD), with the potential to disrupt genome integrity. We used single-nucleus RNA-seq in human postmortem prefrontal cortex samples and found that excitatory neurons in AD were enriched for somatic mosa...
Xiong, Xushen James, Benjamin T Boix, Carles A Park, Yongjin P Galani, Kyriaki Victor, Matheus B Sun, Na Hou, Lei Ho, Li-Lun Mantero, Julio
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Published in
Cell
Recent work has identified dozens of non-coding loci for Alzheimer's disease (AD) risk, but their mechanisms and AD transcriptional regulatory circuitry are poorly understood. Here, we profile epigenomic and transcriptomic landscapes of 850,000 nuclei from prefrontal cortexes of 92 individuals with and without AD to build a map of the brain regulom...