Sharma, Priyanka Shimura, Tadanobu Banwait, Jasjit K Goel, Ajay
Published in
Carcinogenesis
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality in the USA. As much as 50-60% of CRC patients develop resistance to 5-fluorouracil (5FU)-based chemotherapeutic regimens, attributing the increased overall morbidity and mortality. In view of the growing evidence that active principles in various naturally occurri...
Huang, Gena Song, Chen Wang, Ning Qin, Tao Sui, Silei Obr, Alison Zeng, Li Wood, Teresa L Leroith, Derek Li, Man
...
Published in
Carcinogenesis
The insulin receptor gene (INSR) undergoes alternative splicing to give rise to two functionally related, but also distinct, isoforms IR-A and IR-B, which dictate proliferative and metabolic regulations, respectively. Previous studies identified the RNA-binding protein CUGBP1 as a key regulator of INSR splicing. In this study, we show that the diff...
Kufe, Donald W
Published in
Carcinogenesis
Chronic inflammation is a highly prevalent consequence of changes in environmental and lifestyle factors that contribute to the development of cancer. The basis for this critical association has largely remained unclear. The MUC1 gene evolved in mammals to protect epithelia from the external environment. The MUC1-C subunit promotes responses found ...
N Haines, Corinne Klingensmith, Hope D Komara, Makanko Burd, Craig J
Published in
Carcinogenesis
Over 70% of breast cancers express the estrogen receptor (ER) and depend on ER activity for survival and proliferation. While hormone therapies that target receptor activity are initially effective, patients invariably develop resistance which is often associated with activation of the PI3K/Akt/mTOR pathway. While the mechanism by which estrogen re...
Chatterjee, Soumya Chatterjee, Annesha Jana, Samir Dey, Subhasis Roy, Himansu Das, Mrinal Kanti Alam, Jahirul Adhikary, Anindya Chowdhury, Abhisek Biswas, Anupam
...
Published in
Carcinogenesis
Tumor cells promote immune evasion through up regulation of PD-L1 that binds with PD1 on cytotoxic T cells and promote dysfunction. Though therapeutic efficacy of anti PD1 antibody has remarkable effects on different type of cancers it is less effective in breast cancer. Hence more details understanding of PD-L1 mediated immune evasion is necessary...
Beck, Jessica Turnquist, Casmir Horikawa, Izumi Harris, Curtis
Published in
Carcinogenesis
Cellular senescence and the associated secretory phenotype (SASP) promote disease in the aged population. Targeting senescent cells by means of removal, modulation of SASP or through cellular reprogramming represents a novel therapeutic avenue for treating cancer- and age-related diseases such as neurodegeneration, pulmonary fibrosis and renal dise...
O'Brien, Gráinne Cruz-Garcia, Lourdes Zyla, Joanna Brown, Natalie Finnon, Rosemary Polanska, Joanna Badie, Christophe
Published in
Carcinogenesis
Therapy-related and more specifically radiotherapy-associated acute myeloid leukaemia (AML) is a well-recognized potential complication of cytotoxic therapy for the treatment of a primary cancer. The CBA mouse model is used to study radiation leukaemogenesis mechanisms with Sfpi1/PU.1 deletion and point mutation already identified as driving events...
Cheng, Sheng Yang, Bo Xu, Liwei Zheng, Qiming Ding, Guoqing Li, Gonghui
Published in
Carcinogenesis
Epidemiologic cohort studies investigating the association between vasectomy and prostate cancer risk have yielded inconsistent results. The aim of the present meta-analysis is to update the evidence on the association between vasectomy and prostate cancer. A comprehensively literature search of relevant studies was performed in December 2019 using...
Nieuwenhuis, Lisette Simons, Colinda C J M Weijenberg, Matty P van den Brandt, Piet A
Published in
Carcinogenesis
Nut and peanut butter intake are inversely associated with rectal cancer risk in women, and nut intake potentially in men. Peanut butter intake might increase the risk of CRC-tumors that do not develop through the serrated neoplasia pathway in men.
Hamoya, Takahiro Fujii, Gen Iizumi, Yosuke Narita, Takumi Komiya, Masami Matsuzawa, Yui Miki, Kohei Kondo, Tadashi Kishimoto, Shinji Watanabe, Kenji
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Published in
Carcinogenesis
Artesunate (ART) is a clinically approved antimalarial drug and was revealed as a candidate of colorectal cancer chemopreventive agents in our drug screening system. Here, we aimed to understand the suppressive effects of ART on intestinal tumorigenesis. In vitro, ART reduced T-cell factor/lymphoid enhancer factor (TCF/LEF) promoter transcriptional...
