Hua, Surong Gao, Junyi Li, Tong Wang, Mengyi You, Lei Chen, Ge Han, Xianlin Liao, Quan
Published in
Carcinogenesis
Pancreatic cancer is one of the most lethal tumors across the world with an overall 5-year survival rate of 9%, and great efforts have been devoted in early diagnosis and treatment in the past decades. Competing endogenous RNAs are novel and specific regulatory mechanisms of gene expression, and researches have indicated its important roles in tumo...
Stewart, Bernard W
Published in
Carcinogenesis
IARC Monographs are globally-recognized assessments of carcinogenicity published by International Agency for Research on Cancer and directed to national authorities as a contribution to public health. Currently, though not constraining the scope of studies examined, Monographs are declared to involve only hazard identification: a scenario which the...
Lee, Sung Hwan Simoneau, Eve B Karpinets, Tatiana Futreal, P Andrew Zhang, Jianjun Javle, Milind Zhang, Jianhua Vauthey, Jean-Nicolas Lee, Ju-Seog Estrella, Jeannelyn S
...
Published in
Carcinogenesis
In multifocal intrahepatic cholangiocarcinoma (IHC), intrahepatic metastases (IM) represent a contraindication to surgical resection, whereas satellite nodules (SN) do not. However, no consensus criteria exist to distinguish IM from SN. The purpose of this study was to determine genetic alterations and clonal relationships in surgically resected mu...
Wang, Hong Wang, David H Yang, Xu Sun, Yuhai Yang, Chung S
Published in
Carcinogenesis
Colitis increases the risk of colorectal cancer; however, the mechanism of the association between colitis and cancer remains largely unknown. To identify colitis-associated cancer promoting factors, we investigated gene expression changes caused by dextran sulfate sodium (DSS)-induced colitis in mice. By analyzing gene expression profiles, we foun...
Kase, Koji Saito, Motonobu Nakajima, Shotaro Takayanagi, Daisuke Saito, Katsuharu Yamada, Leo Ashizawa, Mai Nakano, Hiroshi Hanayama, Hiroyuki Onozawa, Hisashi
...
Published in
Carcinogenesis
AT-rich interactive domain 1A (ARID1A), which is a tumor suppressor gene, is frequently mutated in Epstein-Barr virus-positive gastric cancer [EBV (+) GC]. While most ARID1A mutations in GC are truncating mutations, leading to loss of ARID1A protein expression, epigenetic modifications appear to contribute to ARID1A deficiency in EBV (+) GC harbori...
Hu, Jian Zhang, Zhi-Qing Zhu, Wei Wu, Zhen-Ru You, Yu Liu, Yan Su, Dai-Wen Wang, Yun-Bing Gong, Jian-Ping
Published in
Carcinogenesis
The difference of the patients bearing hepatocellular carcinoma (HCC) with and without cirrhosis at clinical level has not been completely determined. This study compared their differences in clinicopathological traits and prognostic factors for relapse-free survival (RFS) and overall survival (OS). Animal model was established to validate the resu...
Zou, Donghui Day, Robert Cocadiz, Judy A Parackal, Sarah Mitchell, Wilson Black, Michael A Lawrence, Ben Fitzgerald, Sandra Print, Cristin Jackson, Christopher
...
Published in
Carcinogenesis
Accurate assessment of chemotherapy response provides the means to terminate ineffective treatment, trial alternative drug regimens or schedules and reduce dose to minimize toxicity. Here, we have compared circulating tumor DNA (ctDNA) with carcinoembryonic antigen (CEA) for the cycle by cycle assessment of chemotherapy response in 30 patients with...
Li, Rui Dong, Chengyong Jiang, Keqiu Sun, Rui Zhou, Yang Yin, Zeli Lv, Jiaxin Zhang, Junlin Wang, Qi Wang, Liming
...
Published in
Carcinogenesis
Liver cancer is a major threat to human life and health, and chemotherapy has been the standard non-surgical treatment for liver cancer. However, the emergence of drug resistance of liver cancer cells has hindered the therapeutic effect of chemical drugs. The discovery of exosomes has provided new insights into the mechanisms underlying tumour cell...
Yang, Menghan Arai, Eri Takahashi, Yoriko Totsuka, Hirohiko Chiku, Suenori Taniguchi, Hirokazu Katai, Hitoshi Sakamoto, Hiromi Yoshida, Teruhiko Kanai, Yae
...
Published in
Carcinogenesis
The present study was conducted to clarify the cooperative significance of epigenomic and genomic abnormalities during gastric carcinogenesis. Using 21 samples of normal control gastric mucosa (C), 109 samples of non-cancerous gastric mucosa (N) and 105 samples of cancerous tissue (T) from 109 patients with primary gastric adenocarcinomas, genome-w...
Böttinger, Paula Schreiber, Karin Hyjek, Elizabeth Krausz, Thomas Spiotto, Michael T Steiner, Madeline Idel, Christian Booras, Heather Beck-Engeser, Gabriele Riederer, Jessie
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Published in
Carcinogenesis
Human papillomavirus (HPV) infection is necessary but insufficient for progression of epithelial cells from dysplasia to carcinoma-in situ (CIS) to invasive cancer. The combination of mutant cellular and viral oncogenes that regulate progression of cervical cancer (CC) remains unclear. Using combinations of HPV16 E6/E7 (E+), mutant Kras (mKras) (K+...
