Bergsten, Tova M Burdette, Joanna E Dean, Matthew
Published in
Cancer letters
Ovarian cancer is the most lethal gynecologic malignancy and the fifth leading cause of cancer-related death in women. Although outcomes have improved in recent years, there remains an unmet clinical need to understand the early pathogenesis of ovarian cancer in order to identify new diagnostic approaches and agents of chemoprevention and chemother...
Chen, Kai Che, Jiaming Zhang, Xianfei Jin, Runsen Xiang, Jie Han, Dingpei Sun, Yonghua Gong, Ziying Zhang, Daoyun Li, Hecheng
...
Published in
Cancer letters
Thymic epithelial tumors (TET) including thymomas and thymic carcinomas are rare, but they are common primary tumors in the anterior mediastinum. The etiology and tumorigenesis of TET remain unclear. To better understand the novel aberrations of this rare tumor and provide more significant mutation sites for targeted therapy, we performed next-gene...
Achyut, Bhagelu R Zhang, Hao Angara, Kartik Mivechi, Nahid F Arbab, Ali S Ko, Lan
Published in
Cancer letters
Targeting early lesion in breast cancer is more therapeutically effective. We have previously identified an oncoprotein GT198 (PSMC3IP) in human breast cancer. Here we investigated GT198 in MMTV-PyMT mouse mammary gland tumors and found that GT198 is a shared early lesion in both species. Similar to human breast cancer even before a tumor appears, ...
Xu, Shengchao Tang, Lu Li, Xizhe Fan, Fan Liu, Zhixiong
Published in
Cancer letters
Gliomas are intrinsic brain tumors that originate from neuroglial progenitor cells. Conventional therapies, including surgery, chemotherapy, and radiotherapy, have achieved limited improvements in the prognosis of glioma patients. Immunotherapy, a revolution in cancer treatment, has become a promising strategy with the ability to penetrate the bloo...
Lu, Chunwan Klement, John D Yang, Dafeng Albers, Thomas Lebedyeva, Iryna O Waller, Jennifer L Liu, Kebin
Published in
Cancer letters
Trimethylation of histone 3 lysine 9 (H3K9me3) at gene promoters is a major epigenetic mechanism that silences gene expression. We have developed a small molecule inhibitor for the H3K9me3-specific histone methyltransferase SUV39H1. We report here that FAS expression is significantly down-regulated and SUV39H1 expression is significantly up-regulat...
Kong, Shan Tao, Mei Shen, Xianjuan Ju, Shaoqing
Published in
Cancer letters
Long non-coding RNA (lncRNAs) are functional RNA segments longer than 200 nucleotides, which are considered a redundant transcriptional product. Recently, lncRNAs have been shown to harbor open reading frame (ORF) sequences and encode proteins/peptides. Circular RNAs (circRNAs) have long been considered as another type of non-coding RNA (ncRNA) due...
Zhou, Wolong Liu, Yuanqi Gao, Yang Cheng, Yuanda Chang, Ruimin Li, Xizhe Zhou, Yanwu Wang, Shaoqiang Liang, Lubiao Duan, Chaojun
...
Published in
Cancer letters
MICAL2 is a tumor-promoting factor involved in cell migration, invasion, deformation, and proliferation not yet fully explored in lung adenocarcinoma (LUAD). This study demonstrated that MICAL2 was overexpressed and cytoplasm-enriched in LUAD tissues. Moreover, high cytoplasmic MICAL2 and/or total MICAL2 expression levels were positively correlated...
Gao, Qiang Li, Xiu-Xiu Xu, Yi-Ming Zhang, Jin-Zhao Rong, Shi-di Qin, Yan-Qing Fang, Jing
Published in
Cancer letters
Drug resistance is a big problem in cancer treatment and one of the most prominent mechanisms underlain is overexpression of ATP-binding cassette (ABC) transporters, particularly ABCB1, ABCC1 and ABCG2. Inhibition of ABC transporters is an important approach to overcome drug resistance. The inositol-requiring enzyme 1α (IRE1α), an arm of unfolded p...
Xiao, Yongwei Zhong, Jianing Zhong, Baoyuan Huang, Junyun Jiang, Lixia Jiang, Yu Yuan, Jimin Sun, Jichao Dai, Lingyun Yang, Chuanbin
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Published in
Cancer letters
Colorectal cancer (CRC), a common malignancy, is among the leading causes of cancer-related deaths worldwide. Developing novel biomarkers is an important public health strategy to effectively reduce the mortality of this disease. Recent studies have found that exosomes may be important sources of biomarkers in CRC. Exosomes are nanometer-sized memb...
Lu, Xiao-Jie
Published in
Cancer letters
