Sheta, Mona Hassan, Ghmkin Afify, Said M Monzur, Sadia Kumon, Kazuki Abu Quora, Hagar A Farahat, Mahmoud Zahra, Maram H Fu, Xiaoying Seno, Akimasa
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Published in
Cancer letters
We previously demonstrated the conversion of normal stem cells, including induced pluripotent stem cells (iPSCs), into cancer stem cells (CSCs) without genetic manipulation. Herein, we designed a meta-analysis to assess gene expression profiles in different breast cancer cell lines focusing on the secretory factors responsible for conversion. As a ...
Fraunhoffer, Nicolás A Closa, Daniel Folch-Puy, Emma Abuelafia, Analía Meilerman Calvo, Ezequiel Luis Chuluyan, Eduardo Iovanna, Juan
Published in
Cancer letters
The crosstalk between the transformed tumoral cells and their microenvironment is a key aspect for pancreatic ductal adenocarcinoma (PDAC) progression. This molecular dialog is intensively studied because it may result in an efficient therapeutic target. Contrary to this near microenvironment, the stromal portion in direct contact with the transfor...
Jiang, Yuanyuan Zhan, Hanxiang Zhang, Yuqing Yang, Jingxuan Liu, Mingyang Xu, Chao Fan, Xiao Zhang, Junxia Zhou, Zhijun Shi, Xiuhui
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Published in
Cancer letters
Non-small cell lung cancer (NSCLC) is one of the most critical health problems worldwide, with high incidence and poor survival rate. A zinc importer ZIP4 has been implicated in the process of tumor growth and metastasis of many cancers. However, its exact role and the underlying mechanism in NSCLC remains to be elucidated. In the present study, we...
Wang, Yun Liang, Qian Lei, Kefeng Zhu, Qingqing Zeng, Delong Liu, Yuhong Lu, Yingsi Kang, Tingting Tang, Nannan Huang, Lifen
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Published in
Cancer letters
Metastasis is the major cause of mortality in patients with breast cancer. Understanding the metastatic mechanism to guide clinical diagnoses and the treatment of breast cancer remains a challenge. We found that the expression of Mex-3 RNA binding family member A (MEX3A) was upregulated significantly and related to tumor grade in breast cancer. The...
An, Yao Jiang, Jingwen Zhou, Li Shi, Jinyu Jin, Ping Li, Lei Peng, Liyuan He, Siyu Zhang, Wenhui Huang, Canhua
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Published in
Cancer letters
Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers worldwide and lacks effective treatment. Herein, we found that the antifungal Natamycin (NAT) exhibits antitumor activity by inducing apoptosis both in vitro and in vivo. Mechanistically, NAT downregulates the expression of Peroxiredoxin 1 (PRDX1) by promoting ubiquitina...
La Camera, Giusi Gelsomino, Luca Malivindi, Rocco Barone, Ines Panza, Salvatore De Rose, Daniela Giordano, Francesca D'Esposito, Vittoria Formisano, Pietro Bonofiglio, Daniela
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Published in
Cancer letters
Extracellular vesicles (EVs) are emerging key protagonists in intercellular communication between adipocytes and breast cancer (BC) cells. Here, we described a new mechanism by which EVs released by mature adipocytes promoted breast cancer cell malignancy "in vitro" and "in vivo". We found that adipocyte-derived EVs enhanced growth, motility and in...
Martínez-López, Angélica García-Casas, Ana Bragado, Paloma Orimo, Akira Castañeda-Saucedo, Eduardo Castillo-Lluva, Sonia
Published in
Cancer letters
Cancer-associated fibroblasts (CAFs) are highly abundant stromal components in the tumour microenvironment. These cells contribute to tumorigenesis and indeed, they have been proposed as a target for anti-cancer therapies. Similarly, targeting the Rho-GTPase RAC1 has also been suggested as a potential therapeutic target in cancer. Here, we show tha...
Hu, Jinghui Guan, Zhenxin Chen, Jing
Published in
Cancer letters
A characteristic feature of solid tumors is their low oxygen tension, which confers resistance to radiotherapy, photodynamic therapy, and chemotherapy. Therefore, to improve treatment outcomes, it is critical to develop biomaterials capable of targeted modulation of oxygen levels in tumors. In this review, we summarize four types of oxygen-modulati...
Chen, Bing Deng, Ya-Nan Wang, Xixi Xia, Zijing He, Yu Zhang, Peng Syed, Samina Ejaz Li, Qiu Liang, Shufang
Published in
Cancer letters
We previously reported the inhibitory effects of microRNA-26a (miR-26a) on the conversion of pyruvate to acetyl coenzyme A in glucose metabolism by directly targeting pyruvate dehydrogenase protein X component in colorectal cancer (CRC) cells (Chen B et al., BMC Cancer 2014). Here, using microRNA in situ hybridization, we confirmed that miR-26a lev...
Yamawaki, Kaoru Mori, Yutaro Sakai, Hiroaki Kanda, Yusuke Shiokawa, Daisuke Ueda, Haruka Ishiguro, Tatsuya Yoshihara, Kosuke Nagasaka, Kazunori Onda, Takashi
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Published in
Cancer letters
Patient-derived cells and xenografts retain the biological characteristics of clinical cancers and are instrumental in gaining a better understanding of the chemoresistance of cancer cells. Here, we have established a panel of patient-derived spheroids from clinical materials of ovarian cancer. Systematic evaluation using therapeutic agents indicat...
