Li, Qiaolin Chen, Kang Huang, Wenchao Ma, Haosong Zhao, Xingyang Zhang, Jinde Zhang, Yueming Fang, Chihua Nie, Liming
Published in
Cancer letters
Nanoparticle-based photothermal ablation (PTA) has been intensively investigated recently. However, the poor biocompatibility of most PTA agents and potential long-term toxicity obstruct their clinical translation. Meanwhile, previous PTA studies are limited to surface tumors because of insufficient light penetration depth of near-infrared (NIR) li...
Dutta, Indrani Dieters-Castator, Dylan Papatzimas, James W Medina, Anais Schueler, Julia Derksen, Darren J Lajoie, Gilles Postovit, Lynne-Marie Siegers, Gabrielle M
Published in
Cancer letters
Gamma delta T cells (γδTc) have tremendous anti-tumoral activity, thus γδTc immunotherapy is currently under development for various malignancies. We targeted breast cancer stem-like cells (BCSC), a rare cell population responsible for patient mortality. BCSC were mostly susceptible to γδTc immunotherapy, yet some escaped. The BCSC secretome render...
Wang, Lu Xiong, Xiao Yao, Zhimeng Zhu, Jianlin Lin, Yusheng Lin, Wan Li, Kai Xu, Xiaozheng Guo, Yi Chen, Yuping
...
Published in
Cancer letters
Transcription-induced chimeric RNAs are an emerging area of research into molecular signatures for disease biomarker and therapeutic target development. Despite their importance, little is known for chimeric RNAs-relevant roles and the underlying mechanisms for cancer pathogenesis and progression. Here we describe a unique ASTN2-PAPPAantisense chim...
Chang, Kai-Fu Huang, Xiao-Fan Chang, Jinghua Tsai Huang, Ya-Chih Weng, Jun-Cheng Tsai, Nu-Man
Published in
Cancer letters
Glioblastoma (GBM) is the most common and aggressive primary brain tumor with great invasiveness and resistance to chemotherapy, which presents a treatment challenge. In this study, we investigated the antitumor effect of Cedrol, a sesquiterpene alcohol isolated from Cedrus atlantica, against GBM cells in vitro and in vivo. Cedrol was found to pote...
Oh, Ji Hoon Lee, Ji-Yeon Kim, Kwang H Kim, Clara Yuri Jeong, Da Som Cho, Yejin Nam, Ki Taek Kim, Myoung Hee
Published in
Cancer letters
Approximately 70% of breast cancers are estrogen receptor (ER)-positive and treated with endocrine therapy. A commonly used treatment agent, tamoxifen, shows high efficacy for improving prognosis. However, approximately one-third of patients treated with tamoxifen develop resistance to this drug. Here, we investigated the function of general contro...
Abdollahi, Pegah Köhn, Maja Børset, Magne
Published in
Cancer letters
Many cell signaling pathways are activated or deactivated by protein tyrosine phosphorylation and dephosphorylation, catalyzed by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), respectively. Even though PTPs are as important as PTKs in this process, their role has been neglected for a long time. Multiple myeloma (MM) is a...
Santofimia-Castaño, Patricia Lan, Wenjun Xia, Yi Zhou, Zhengwei Huang, Can Barea, Dolores Cervello, Melchiore Giannitrapani, Lydia Montalto, Giuseppe Peng, Ling
...
Published in
Cancer letters
Rostamian, Hosein Fallah-Mehrjardi, Keyvan Khakpoor-Koosheh, Mohammad Pawelek, John M Hadjati, Jamshid Brown, Christine E Mirzaei, Hamid R
Published in
Cancer letters
Therapeutic efficacy of chimeric antigen receptor (CAR) T cells is associated with their expansion, persistence and effector function. Although CAR T cell therapy has shown remarkable therapeutic effects in hematological malignancies, its therapeutic efficacy has been limited in some types of cancers - in particular, solid tumors - partially due to...
Bungsy, Manisha Palmer, Michaela C L Jeusset, Lucile M Neudorf, Nicole M Lichtensztejn, Zelda Nachtigal, Mark W McManus, Kirk J
Published in
Cancer letters
Despite high-grade serous ovarian cancer (HGSOC) being the most common and lethal gynecological cancer in women, the early etiological events driving disease development remain largely unknown. Emerging evidence now suggests that chromosome instability (CIN; ongoing changes in chromosome numbers) may play a central role in the development and progr...
Wang, Lixia Yang, Chuanlai Chu, Man Wang, Zhi-Wei Xue, Boxin
Published in
Cancer letters
Ionizing radiation is a conventional therapy for cancer patients, but patients often experience distant metastasis and recurrence, which lead to a poor prognosis after the implementation of this treatment. Moreover, the underlying mechanisms by which radioresistance contributes to metastatic potential is still elusive. Here, we explored the molecul...
