Published in Cancer letters
The chemotherapeutic action of Bleomycin, applied at a dosage which induced only a non-specific tumor inhibition on HRS-sarcoma, was potentiated by combination with inosine. This combination, without increasing toxicity, effected both a significant tumor inhibition and a significant curative action.
Published in Cancer letters
The growth of a transplantable myeloid leukaemia into its syngeneic host is accompanied by a progressive increase in the number of blood monocytes. These were shown to be of host origin and were not derived from the inoculated leukaemia cells. The host response which is responsible for the monocytosis differs from that associated with the entry of ...
Published in Cancer letters
A high incidence of pancreatic duct adenomas and carcinomas were induced in Syrian golden hamsters as early as 13 weeks after chronic administration of 2,2'-dioxopropyl-n-propylnitrosamine (DOPN) at a 10 mg/kg dose. In contrast to another pancreatic carcinogen, 2,2'-dihydroxy-propyl-n-propyl-nitrosamine, DOPN induced no tumors of the upper respirat...
Published in Cancer letters
Three groups of Chinese hamsters (20 males, 20 females/group) received weekly subcutaneous injections for life of dimethylnitrosamine (DMN) at dose levels 0.20, 0.10 and 0.05 of the LD50. Eighty-two to 100% of the animals developed tumors of vascular origin. The neoplasms were primarily hepatic hemangioendotheliomas and their incidence was unrelate...
Published in Cancer letters
The number of macrophages present in 44 surgically removed breast tumours and melanomas was determined by making a cell suspension and measuring the proportion of cells which bound a heterologous anti-macrophage serum and spread rapidly in culture. The macrophage content of the different tumours ranged from 0% to 30%. The malignant tumours which we...
Published in Cancer letters
Alterations in the ultrastructure of cilia were found to be one of the initial stages in the development of benzo(a)pyrene induced cancers in the trachea and bronchi of Syrian golden hamsters, as well as in the bronchi from which pulmonary adenocarcinomata originated after European hamsters were treated with N-dibutylnitrosamine. Similar abnormalit...
Published in Cancer letters
Purified protein derivative (PPD) (a soluble protein from tubercle bacilli), when injected together with sarcoma cells into syngeneic mice that had been immunized previously with Bacillus Calmitte-Guérin (BCG), prevents tumour toxic to sarcoma cells [4]. However, non-adherent mononuclear peritoneal exudate cells from BCG-treated mice were also foun...
Published in Cancer letters
Five modified anilines were identified in ethyl acetate extract from hydrolysed urine of rats which had been injected with the carcinogenic 1-(4-chlorophenyl)-3,3-dimethyltriazene. 4-Chloro-2-hydroxyaniline (15.1%) and 4-chloroaniline (5.2%) were the most abundant metabolites arising by in vivo fission of the diazoamino group. The structures and di...
Published in Cancer letters
Chronic administration of saccharin and sodium or calcium cyclamates in drinking water to Syrian golden hamsters, up the maximum tolerated dose level, failed to induce an excess of tumors compared to controls; nor were any urinary bladder tumors found.
Published in Cancer letters
4-Hydroxybutyl-butylnitrosamine (HBBN), a urinary metabolite of dibutylnitrosamine (DBN) was shown to induce respiratory and bile duct tumors as well as carcinomas of the urinary bladder in Syrian golden hamsters. This contrasts with results previously obtained in rats and demonstrates that HBBN is not a specific bladder carcinogen. Bronchogenic tu...
