Bungsy, Manisha Palmer, Michaela C L Jeusset, Lucile M Neudorf, Nicole M Lichtensztejn, Zelda Nachtigal, Mark W McManus, Kirk J
Published in
Cancer letters
Despite high-grade serous ovarian cancer (HGSOC) being the most common and lethal gynecological cancer in women, the early etiological events driving disease development remain largely unknown. Emerging evidence now suggests that chromosome instability (CIN; ongoing changes in chromosome numbers) may play a central role in the development and progr...
Wang, Lixia Yang, Chuanlai Chu, Man Wang, Zhi-Wei Xue, Boxin
Published in
Cancer letters
Ionizing radiation is a conventional therapy for cancer patients, but patients often experience distant metastasis and recurrence, which lead to a poor prognosis after the implementation of this treatment. Moreover, the underlying mechanisms by which radioresistance contributes to metastatic potential is still elusive. Here, we explored the molecul...
Tien, Pei-Chieh Quan, Menchus Kuang, Shihuan
Published in
Cancer letters
Cells in a tumor are heterogeneous, often including a small number of tumor-initiating cells (TICs) and the majority of cancerous and non-cancerous cells. We have previously reported that constitutive activation of Notch signaling in adipocytes of mice leads to dedifferentiated liposarcoma (DDLPS), an aggressive liposarcoma (LPS) with no effective ...
Yin, Hang Wang, Xiaoyuan Zhang, Xue Zeng, Yangyang Xu, Qingyong Wang, Wenbo Zhou, Fuxiang Zhou, Yunfeng
Published in
Cancer letters
Radiation resistance affects survival in non-small-cell lung cancer (NSCLC) patients. Further exploration of mechanisms and targets is urgently needed. Using bioinformatic analyses, we found that UBE2T is associated with survival, tumor size, lymph node metastasis and distant metastasis. Then, real-time PCR and immunohistochemistry were performed t...
Peng, Wen Zhang, Chuan Peng, Jianing Huang, Yuanjian Peng, Chaofan Tan, Yuqian Ji, Dongjian Zhang, Yue Zhang, Dongsheng Tang, Junwei
...
Published in
Cancer letters
The mitogen activated protein kinase (MAPK) pathway has been reported to be involved in many cancer developments. Normally, MAPK activity is self-limited between rapid phosphorylation and dephosphorylation. In abnormal conditions, however, this dynamic equilibrium is broken, trigging tumor-suppressing or -promoting roles. While dual-specificity MAP...
Murphy, Anthony Costa, Max
Published in
Cancer letters
Nuclear protein 1 (NUPR1) also known as p8 and candidate of metastasis 1 (COM1) functions as a transcriptional regulator, and plays a role in cell cycle, DNA damage response, apoptosis, autophagy, and chromatin remodeling in response to various cellular stressors. Since it was first suggested to contribute to cancer development and progression in 1...
Feltrin, Sara Ravera, Francesco Traversone, Noemi Ferrando, Lorenzo Bedognetti, Davide Ballestrero, Alberto Zoppoli, Gabriele
Published in
Cancer letters
Sterol synthesis is a highly complex and integrated pathway in mammals. In the present review, we briefly summarize the main steps of this pathway, especially concerning its main rate-limiting enzymes, HMG-CoA reductase (HMGCR) and squalene epoxidase (SQLE), in relation with cancer. We focus on studies reporting key findings linking cholesterol wit...
Xie, Shanshan Chang, Yongxia Jin, Hao Yang, Feng Xu, Yanjun Yan, Xiaoyi Lin, Aifu Shu, Qiang Zhou, Tianhua
Published in
Cancer letters
Non-coding RNAs (ncRNAs) are functional RNA molecules that play crucial regulatory roles in many fundamental biological processes. The dysregulation of ncRNAs is significantly associated with the progression of human cancers, including gastric cancer. In this review, we have summarized the oncogenic or tumor-suppressive roles and the regulatory mec...
Yu, Jun Gemenetzis, Georgios Kinny-Köster, Benedict Habib, Joseph R Groot, Vincent P Teinor, Jonathan Yin, Lingdi Pu, Ning Hasanain, Alina van Oosten, Floortje
...
Published in
Cancer letters
Single-cell next-generation sequencing (scNGS) technology has been widely used in genomic profiling, which relies on whole-genome amplification (WGA). However, WGA introduces errors and is especially less accurate when applied to single nucleotide variant (SNV) analysis. Targeted scNGS for SNV without WGA has not been described. We aimed to develop...
Tao, Huimin Cheng, Lu Liu, Lihua Wang, Hong Jiang, Zhijie Qiang, Xu Xing, Lijun Xu, Yifeng Cai, Xinying Yao, Jing
...
Published in
Cancer letters
Antibodies blocking the PD-1/PD-L1 pathway have achieved great success. However, some disadvantages of antibodies have been found, which limit their clinical applications. Peptide antagonists are alternatives to antibodies in PD-1/PD-L1 blockage, but successful studies in this area are limited. A PD-1 targeting peptide, P-F4, was identified using p...
