Todeschini, Paola Salviato, Elisa Paracchini, Lara Ferracin, Manuela Petrillo, Marco Zanotti, Laura Tognon, Germana Gambino, Angela Calura, Enrica Caratti, Giulia
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Published in
Cancer letters
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecologic neoplasm, with five-year survival rate below 30%. Early disease detection is of utmost importance to improve HGSOC cure rate. Sera from 168 HGSOC patients and 65 healthy controls were gathered together from two independent collections and stratified into a training set, for ...
Amponsah, Prince Saforo Fan, Pei Bauer, Nathalie Zhao, Zhefu Gladkich, Jury Fellenberg, Joerg Herr, Ingrid
Published in
Cancer letters
Resistance to first-line chemotherapies like gemcitabine contributes to high disease lethality in pancreatic cancer. By microarray and qRT-PCR, we observed significant downregulation of microRNA-210 in gemcitabine-resistant cells. The overexpression of microRNA-210 was toxic to gemcitabine-resistant cells and enhanced gemcitabine sensitivity. Micro...
Sun, Kai Xu, Lingyun Jing, Yingying Han, Zhipeng Chen, Xiaojing Cai, Chenlei Zhao, Peipei Zhao, Xue Yang, Liqun Wei, Lixin
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Published in
Cancer letters
As a cellular degradation mechanism, autophagy exerts crucial and complicated effects on HCC development. Liver non-parenchymal cells, including hepatic resident macrophage Kupffer cells, also play important roles in this process. However, most associated studies have focused on the influence of the autophagy level in hepatic cells and HCC cells, b...
Wang, Weijun Zhang, Yaxing Yang, Ling Li, Hongliang
Published in
Cancer letters
The innate immune system is responsible for sensing pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) by several types of germline-encoded pattern-recognition receptors (PRRs). It has the capacity to help the human body maintain homeostasis under normal conditions. However, in pathological conditions, PA...
Renfro, Lindsay A An, Ming-Wen Mandrekar, Sumithra J
Published in
Cancer letters
Traditionally, site of disease and anatomic staging have been used to define patient populations to be studied in individual cancer clinical trials. In the past decade, however, oncology has become increasingly understood on a cellular and molecular level, with many cancer subtypes being described as a function of biomarkers or tumor genetic mutati...
Wu, Guang Wilson, George George, Jacob Liddle, Christopher Hebbard, Lionel Qiao, Liang
Published in
Cancer letters
Chemotherapy is the standard treatment for many, if not all, metastatic cancers. While chemotherapy is often capable of inducing cell death in tumors leading to shrinkage of the tumor bulk, many patients suffer from recurrence and ultimately death due to resistance. During the last decade, treatment resistance has attracted great attention followed...
Abba, Mohammed L Patil, Nitin Leupold, Jörg H Moniuszko, Marcin Utikal, Jochen Niklinski, Jacek Allgayer, Heike
Published in
Cancer letters
MicroRNAs (miRNAs) are currently experiencing a renewed peak of attention not only as diagnostics but also especially as highly promising novel targets or tools for clinical therapy in several different malignant diseases. Moreover, the recent discovery of competing endogenous RNAs (ceRNAs) as novel miRNA-regulators has contributed exciting insight...
Economopoulou, Panagiota Psyrri, Amanda
Published in
Cancer letters
Microarray and next generation sequencing has led to the exploration of correlated gene patterns and their shared functions. Gene modulators are proteins that alter the activity of transcription factors and influence the expression of their target genes. It is assumed that modulators are dependent on transcription factors. Several algorithms have b...
Sayin, Volkan I Papagiannakopoulos, Thales
Published in
Cancer letters
Cancer is a multistep process that arises from a series of genetic and epigenetic events. With recent technological advances there has been a burst in genome sequencing and epigenetic studies revealing a plethora of alterations that may contribute to cancer. However, the great challenge for the cancer research community is the systematic functional...
Prasad, Sahdeo Gupta, Subash C Tyagi, Amit K
Published in
Cancer letters
Extensive research over the past half a century indicates that reactive oxygen species (ROS) play an important role in cancer. Although low levels of ROS can be beneficial, excessive accumulation can promote cancer. One characteristic of cancer cells that distinguishes them from normal cells is their ability to produce increased numbers of ROS and ...
