Zhang, Yuanyuan Wang, Yuqi Wei, Youheng Wu, Jiaxue Zhang, Pingzhao Shen, Suqin Saiyin, Hexige Wumaier, Reziya Yang, Xianmei Wang, Chenji
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Published in
Cancer letters
CCT3 was one of the subunits of molecular chaperone CCT/TRiC complex, which plays a central role in maintaining cellular proteostasis. We demonstrated that expressions of CCT3 mRNA and protein are highly up-regulated in hepatocellular carcinoma (HCC) tissues, and high level of CCT3 is correlated with poor survival in cancer patients. In HCC cell li...
Xu, Zhuobin Wang, Zegen Jia, Xuelian Wang, Luxuan Chen, Zhiguo Wang, Shijing Wang, Min Zhang, Juan Wu, Min
Published in
Cancer letters
Increasing evidence suggests that DLL4 (Delta-like 4)-Notch signaling plays a critical role in cell fate determination and differentiation in tissues. Blocking DLL4-Notch signaling results in inhibition of tumor growth, which is associated with increased nonfunctional vessels and poor perfusion in the tumor. We successfully generated a human DLL4 m...
Jacob, Jimmy Favicchio, Rosy Karimian, Negin Mehrabi, Maryam Harding, Victoria Castellano, Leandro Stebbing, Justin Giamas, Georgios
Published in
Cancer letters
Lemur tyrosine kinase-3 (LMTK3) plays an important role in cancer progression and is associated with breast, lung, gastric and colorectal cancer. MicroRNAs (miRNAs) are small endogenous non-coding RNAs that typically repress target genes at post-transcriptional level and have an important role in tumorigenesis. By performing a miRNA expression prof...
Jakhar, Rekha Paul, Souren Bhardwaj, Monika Kang, Sun Chul
Published in
Cancer letters
Apoptosis and autophagy are genetically regulated, evolutionarily conserved processes that can jointly seal cancer cell fates, and numerous death stimuli are capable of activating either pathway. Although crosstalk between apoptosis and autophagy is quite complex and sometimes contradictory, it remains a key factor determining the outcomes of death...
Lee, Da Hyun Jung Jung, You Koh, Dongsoo Lim, Yoongho Lee, Young Han Shin, Soon Young
Published in
Cancer letters
The primary aim of this study was to find novel chemopreventive agents effective against breast cancer. Endoplasmic reticulum (ER) stress can induce apoptosis through the unfolded protein response (UPR). 2'-Hydroxy-2,3,5'-trimethoxychalcone (DK143) is a synthetic flavonoid derivative. The present study provides evidence supporting the role of the U...
Zhang, Shile Wei, Jun S Li, Samuel Q Badgett, Tom C Song, Young K Agarwal, Saurabh Coarfa, Cristian Tolman, Catherine Hurd, Laura Liao, Hongling
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Published in
Cancer letters
The molecular mechanisms underlying the aggressive behavior of MYCN driven neuroblastoma (NBL) is under intense investigation; however, little is known about the impact of this family of transcription factors on the splicing program. Here we used high-throughput RNA sequencing to systematically study the expression of RNA isoforms in stage 4 MYCN-a...
Gwak, HyeRan Kim, Soochi Dhanasekaran, Danny N Song, Yong Sang
Published in
Cancer letters
Malignant tumors have a high glucose demand and alter cellular metabolism to survive. Herein, focusing on the utility of glucose metabolism as a therapeutic target, we found that resveratrol induced endoplasmic reticulum (ER) stress-mediated apoptosis by interrupting protein glycosylation in a cancer-specific manner. Our results indicated that resv...
Phelan, J J Feighery, R Eldin, O S Meachair, S Ó Cannon, A Byrne, R MacCarthy, F O'Toole, D Reynolds, J V O'Sullivan, J
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Published in
Cancer letters
In Barrett associated tumorigenesis, oxidative phosphorylation and glycolysis are reprogrammed early in the disease sequence and act mutually to promote disease progression. However, the link between energy metabolism and its connection with other central cellular processes within the Barrett microenvironment is unknown. The aim of this study was t...
Liao, Jie Hwang, Sung Hee Li, Haonan Yang, Yihe Yang, Jun Wecksler, Aaron T Liu, Jun-Yan Hammock, Bruce D Yang, Guang-Yu
Published in
Cancer letters
Mutant Kras and chronic pancreatitis are the most common pathological events involved in human pancreatic cancer. It has been demonstrated that c-Raf is responsible for transmitting signals from mutant Ras to its downstream signals including MEK-ERK and for initiating carcinogenesis. The soluble epoxide hydrolase (sEH), a pro-inflammatory enzyme, g...
Shi, Ying Wang, Junwei Wang, Yuhe Wang, Anna Guo, Hongliang Wei, Feili Mehta, Sanjay R Espitia, Stephen Smith, Davey M Liu, Longgen
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Published in
Cancer letters
Hepatitis B virus (HBV) infection-related hepatocellular carcinoma (HCC) represents a major health problem worldwide. HBV X (HBx) protein is the most common open reading frame that may undergo mutations, resulting in the development of HCC. This study aimed to determine specific HBx mutations that differentiate the central- and para-tumor tissues, ...
