Al-Ghabkari, Abdulhameed Narendran, Aru
Published in
Cancer biology & therapy
Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and a catalytic subunit of the polycomb repressive complex 2 (PRC2) that catalyzes the mono-, di-, and tri-methylation of histone H3 at Lys 27 (H3K27me3) to facilitate chromatin-remodeling and gene-silencing functions. Previous reports showed a significant association of EZH2 aberrat...
Wang, Xiao-Lin Lu, Shi-Chun Sun, Chao Jin, Wei-Guo Fan, Yi-Wei Shu, Yu-Sheng Shi, Hong-Can Min, Ling-Feng
Published in
Cancer biology & therapy
Evidence suggests that Tripartite Motif Containing 11 (TRIM11) has pro-tumor activity in human non-small cell lung cancer (NSCLC). However, the roles and underlying mechanisms of TRIM11 in NSCLC have not yet been fully elucidated. In this work, human lung cancer cell lines (A549, H446, and H1975) were transfected with siRNA or lentiviruses to knock...
Liu, Fengchao Qian, Yanzhi
Published in
Cancer biology & therapy
Cancer stem cells (CSCs) represent a small subpopulation of cells found within tumors that exhibit properties of self-renewal, like normal stem cells. CSCs have been defined as a crucial factor involved in driving cancer relapse, chemoresistance and metastasis. Prominin-1 (CD133) is one of the most well-characterized markers of CSCs in various tumo...
Li, Jutang Dong, Wei Jiang, Qixia Zhang, Fenglian Dong, Hui
Published in
Cancer biology & therapy
In China, gastric cancer (GC) ranks first in the incidence of all malignant tumors. With high recurrence and distant metastasis, GC has caused considerable mortalities. LncRNA long intergenic non-protein-coding RNA 668 (LINC00668) has been reported to be upregulated in GC cells and predict poor prognosis of GC patients. However, the mechanism of LI...
Fernández-Domínguez, Ileana J Manzo-Merino, Joaquin Taja-Chayeb, Lucia Dueñas-González, Alfonso Pérez-Cárdenas, Enrique Trejo-Becerril, Catalina
Published in
Cancer biology & therapy
Nowadays, extracellular DNA or circulating cell-free DNA is considered to be a molecule with clinical applications (diagnosis, prognosis, monitoring of treatment responses, or patient follow-up) in diverse pathologies, especially in cancer. Nevertheless, because of its molecular characteristics, it can have many other functions. This review focuses...
Del Valle, Paulo Roberto Mendonça, Samir Andrade Antunes, Fernanda Hunger, Aline Tamura, Rodrigo E Zanatta, Daniela Bertolini Strauss, Bryan E
Published in
Cancer biology & therapy
While treatments for colorectal cancer continue to improve, some 50% of patients succumb within 5 years, pointing to the need for additional therapeutic options. We have developed a modified non-replicating adenoviral vector for gene transfer, called AdRGD-PG, which offers improved levels of transduction and transgene expression. Here, we employ th...
Xue, Dongdong Han, Jingzhao Liu, Yifan Tuo, Hongfang Peng, Yanhui
Published in
Cancer biology & therapy
The prognosis of hepatocellular carcinoma (HCC), a malignant tumor, is poor. Tumor recurrence and metastasis are the major challenges for the treatment of HCC. Various studies have demonstrated that exosomes, which are loaded with various biomolecules including nucleic acids, lipids, and proteins are involved in the recurrence and metastasis of HCC...
Lv, Yanrong Dong, Ke Gao, Haidong
Published in
Cancer biology & therapy
Accumulated studies have revealed the critical role of long non-coding RNAs (lncRNAs) in the carcinogenesis and progression of various cancers. LncRNA TDRG1 has been reported to exhibit oncogenic potential in some cancers. However, its underlying mechanism regulating breast cancer (BC) remains obscure. QRT-PCR was used to measure the relative expre...
Deland, Lily Keane, Simon Olsson Bontell, Thomas Sjögren, Helene Fagman, Henrik Øra, Ingrid De La Cuesta, Esther Tisell, Magnus Nilsson, Jonas A Ejeskär, Katarina
...
Published in
Cancer biology & therapy
Here we report a case of an 11-year-old girl with an inoperable tumor in the optic chiasm/hypothalamus, who experienced several tumor progressions despite three lines of chemotherapy treatment. Routine clinical examination classified the tumor as a BRAF-negative pilocytic astrocytoma. Copy-number variation profiling of fresh frozen tumor material i...
Lin, Jing Liao, Shasha Liu, Zewa Li, E Wu, Xiaohua Zeng, Wanting
Published in
Cancer biology & therapy
In recent years, FGD5 antisense RNA 1 (FGD5-AS1) was confirmed to be the long non-coding RNAs (lncRNAs) that could accelerate the development of multiple cancers. Nevertheless, specific biological functions and latent mechanism of FGD5-AS1 were not yet clear in pancreatic cancer (PC). This research was aimed to search the functions of FGD5-AS1 on t...
