Pan, Zongfu Li, Lu Qian, Yangyang Ge, Xinyang Hu, Xiaoping Zhang, Yiwen Ge, Minghua Huang, Ping
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Cancer biology & therapy
Unlike papillary thyroid cancer (PTC), anaplastic thyroid carcinoma (ATC) is extremely aggressive and rapidly lethal without effective therapies. However, the differences of master regulators and regulatory networks between PTC and ATC remain unclear. Methods: Three representative datasets comprising 32 ATC, 69 PTC, and 78 normal thyroid tissue sam...
Wang, Tao Liu, Zhengsheng Wang, Xuegang Bai, Peide Sun, Anran Shao, Zhiqiang Luo, Rongtuan Wu, Zhun Zhang, Kaiyan Li, Wei
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Cancer biology & therapy
Patients with urothelial carcinoma (UC) of the bladder have a high risk of death in China. However, a lack of comprehensive molecular profiling in Chinese Han population hinders the development of targeted therapies for bladder cancer. In our present study, we collected fresh bladder tumors from low-grade (T1, N0, M0, G1) non-muscle invasive bladde...
Yang, Jinghui Yu, Duo Liu, Xueshibojie Changyong, E Yu, Shan
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Cancer biology & therapy
Glioma is the most prevalent brain malignancy with high mortality. In recent decades, the regulatory role of long noncoding RNAs (lncRNAs) has been unmasked in glioma. In this study, we focused on the function and mechanism of LINC00641 in glioma. First of all, we found that LINC00641 was expressed at a low level in glioma cell lines. Importantly, ...
Lei, Lei Mou, Qinwei
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Cancer biology & therapy
Emerging evidence had highlighted that exosomes could mediate cell-cell communication in human cancerous development via transferring the various molecular cargos, including long non-coding RNA (lncRNA). Taurine up-regulated 1 (TUG1) was previously reported as an oncogenic lncRNA in cervical cancer (CC) via facilitating cell proliferation and other...
Zheng, Yurong Ding, Xiaowen Zou, Dehong Zhang, Fanrong Qin, Chengdong Yang, Hongjian Mo, Wenju Ding, Yuqin Yu, Yang
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Cancer biology & therapy
Patients' responses to breast cancer neoadjuvant chemotherapy (NACT) differ because of heterogeneous tumor characteristics. Reports about NACT progression are sporadic. Here we enrolled 1187 patients who received NACT in our cancer center between January 1, 2007, and December 31, 2016. We analyzed the characteristics and treatments of patients with...
Santoro, Angela Bufo, Pantaleo Russo, Giuseppe Cagiano, Simona Papagerakis, Silvana Bucci, Paolo Aquino, Gabriella Longo, Francesco Feola, Antonia Giordano, Antonio
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Cancer biology & therapy
Epithelial-Mesenchymal Transition (EMT) and angiogenesis are crucial events for development of aggressive and often fatal Oral Squamous Cell Carcinomas (OSCCs). Both promote cancer progression and metastasis development, but while the former induces the loss of E-cadherin expression and, hence cadherin switching; the latter produces hematic blood v...
Lee, Sang Hoon Kim, Eun Young Kim, Arum Chang, Yoon Soo
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Cancer biology & therapy
In total, 102 cases diagnosed as lung adenocarcinoma with EGFR-tyrosine kinase inhibitor (TKI) sensitizing mutations (mEGFR) and had been treated with 1st ~ 2nd generation EGFR-TKI alone were enrolled for this study. De novo T790 M status was tested using the tissues at the initial diagnosis and positivity was defined as the ratio of T790 M/wild-ty...
Zheng, Wenbo Yang, Chunzhao Qiu, Ling Feng, Xiaochuang Sun, Kai Deng, Haijun
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Cancer biology & therapy
Despite recent progress in screening survival-related genes, there have been few attempts to apply methods based on cancer stem cells (CSCs) for prognosis. We aimed to identify a CSC-based model to predict survival in colorectal cancer (CRC) patients. Differentially expressed genes between CRC and normal tissues and between CD133- and CD133+ cells ...
Min, Shengping Wang, Xiaoxu Du, Qianyu Gong, Huiyuan Yang, Yan Wang, Tao Wu, Nan Liu, Xincheng Li, Wei Zhao, Chengling
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Cancer biology & therapy
Non-small cell lung cancer (NSCLC) remains recalcitrant to effective treatment due to tumor relapse and acquired resistance. Cancer stem cells (CSCs) are believed to be one mechanism for relapse and resistance and are consequently considered promising drug targets. We report that chetomin, an active component of Chaetomium globosum, blocks heat sho...
Yan, Anqi Chen, Guanhao Nie, Jichan
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Cancer biology & therapy
