Zhang, Dong Liu, Haitao Wang, Weihua Xu, Gang Yin, Chenxiao Wang, Songgang
Published in
Cancer biology & therapy
This study was designed to explore the prognostic significance and functionality of STEAP2 (six-transmembrane epithelial antigen of prostate 2) in osteosarcomas and determine whether EFEMP2 (Epidermal growth factor-containing fibulin-like extracellular matrix protein 2) targets STEAP2 to facilitate osteosarcoma cell infiltration and migration. STEA...
Krishn, Shiv Ram Garcia, Vaughn Naranjo, Nicole M Quaglia, Fabio Shields, Christopher D Harris, Maisha A Kossenkov, Andrew V Liu, Qin Corey, Eva Altieri, Dario C
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Published in
Cancer biology & therapy
The αVβ6 integrin, an epithelial-specific cell surface receptor absent in normal prostate and expressed during prostate cancer (PrCa) progression, is a therapeutic target in many cancers. Here, we report that transcript levels of ITGB6 (encoding the β6 integrin subunit) are significantly increased in metastatic castrate-resistant androgen receptor-...
Han, Duo Zhu, Shaihong Li, Xia Li, Zhiqiang Huang, Hui Gao, Wenzhe Liu, Yunfei Zhu, Hongwei Yu, Xiao
Published in
Cancer biology & therapy
Pancreatic cancer is one of the malignancies having the poorest prognosis due to late diagnoses and lack of efficient treatment regimens. The identification of potential miRNA-targeted gene axes could act as targets for developing novel treatment strategies. Herein, it was assessed that miR-488 expression was markedly downregulated within pancreati...
Napoli, Giulia C Chau, Cindy H Figg, William D
Published in
Cancer biology & therapy
As precision oncology evolves toward developing more targeted therapies, sequencing has moved to the forefront of treatment decision-making. Whole genome sequencing (WGS) has emerged as a technology capable of identifying candidates for rare and targeted treatments. Yet, because the tumor is constantly evolving during relapse and therapy resistance...
Wandishin, Clayton M Robbins, Charles John Tyson, Darren R Harris, Leonard A Quaranta, Vito
Published in
Cancer biology & therapy
The drug-induced proliferation (DIP) rate is a metric of in vitro drug response that avoids inherent biases in commonly used metrics such as 72 h viability. However, DIP rate measurements rely on direct cell counting over time, a laborious task that is subject to numerous challenges, including the need to fluorescently label cells and automatically...
Fang, Qingxia Lin, Jingyang Gao, Liang Pan, Ruolang Zheng, Xiaochun
Published in
Cancer biology & therapy
Defects in tRNA expressions and modifications had been linked to various types of tumorigenesis and progression in recent studies, including colorectal cancer. In the present study, we evaluated transcript levels of mitochondrial tyrosyl-tRNA synthetase YARS2 in both colorectal cancer tissues and normal colorectal tissues using qRT-PCR. The results...
Guo, Tianxing Zhang, Zhenlong Zhu, Lihuan Chen, Wenshu Ding, Yun Li, Wujin Huang, Yangyun Huang, Jianyuan Pan, Xiaojie
Published in
Cancer biology & therapy
Up until now, cancer refractoriness and distal organ metastatic disease remain as major obstacles for oncologists to achieve satisfactory therapeutic effects for lung adenocarcinoma patients. Previous studies indicated that TRIM55, which participates in the natural development of muscle and cardiovascular system, plays a protective role in hepatoce...
Lee, Kristi Y Chau, Cindy H Price, Douglas K Figg, William D
Published in
Cancer biology & therapy
The vast majority of the human proteome is yet to be functionally characterized thus hindering ongoing investigations on potential drug resistance mechanisms and advanced treatment options. Chemical proteomics is a powerful solution for enzyme profiling and the development of next generation cancer therapeutics previously deemed undruggable by smal...
Vigoda, Myles Mathieson, Chase Evans, Nathaniel Hale, Carolyn Jennings, Jennifer Lucero, Olivia Jeng, Sophia Bottomly, Daniel Clayburgh, Daniel Andersen, Peter
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Published in
Cancer biology & therapy
In this study, we report a differential response of mitogen-activated protein kinase-kinase (MEK) inhibitor trametinib in 20 head and neck squamous cell carcinoma (HNSCC) patients' tumor-derived cell cultures. Relatively sensitive and resistant cases to trametinib were identified using high throughput metabolic assays and validated in extended dose...
Ala, Moein
Published in
Cancer biology & therapy
C-Myc overexpression is a common finding in pancreatic cancer and predicts the aggressive behavior of cancer cells. It binds to the promoter of different genes, thereby regulating their transcription. C-Myc is downstream of KRAS and interacts with several oncogenic and proliferative pathways in pancreatic cancer. C-Myc enhances aerobic glycolysis i...
