Esma Yagdi Aloran Mazumder Jin-Young Lee Anthoula Gaigneaux Flavia Radogna Muhammad Jawad Nasim Christo Christov Claus Jacob Kyu-Won Kim Mario Dicato
...
Published in
Cancer Letters
Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors and apoptosis inducers. Here, we translate their application in colorectal cancer (CRC). MALDI-TOF-MS analysis identified both compounds as reversible tubulin binde...
Singh, Jay Prakash Zhang, Kaisi Wu, Jing Yang, Xiaoyong
Published in
Cancer letters
The covalent attachment of β-D-N-acetylglucosamine monosaccharides (O-GlcNAc) to serine/threonine residues of nuclear and cytoplasmic proteins is a major regulatory mechanism in cell physiology. Aberrant O-GlcNAc modification of signaling proteins, metabolic enzymes, and transcriptional and epigenetic regulators has been implicated in cancer. Relen...
Zhou, Weidong Liotta, Lance A Petricoin, Emanuel F
Published in
Cancer letters
Cancer metabolism has been extensively investigated by various tools, and the fact of diverse metabolic reprogramming in cancer cells has been gradually unveiled. In this review, we discuss some contributions in cancer metabolism by general proteomic analysis and post-translational modification analysis using mass spectrometry (MS) technique. Inste...
Gruenbacher, Georg Thurnher, Martin
Published in
Cancer Letters
Cancer cells are characterized by sustained proliferative signaling, insensitivity to growth suppressors and resistance to apoptosis as well as by replicative immortality, the capacity to induce angiogenesis and to perform invasive growth. Additional hallmarks of cancer cells include the reprogramming of energy metabolism as well as the ability to ...
Søreide, Kjetil Sund, Malin
Published in
Cancer letters
Pancreatic cancer remains one of the deadliest human cancers with little progress made in survival over the past decades, and 5-year survival usually below 5%. Despite this dismal scenario, progresses have been made in understanding of the underlying tumor biology through among other definition of precursor lesions, delineation of molecular pathway...
Cerella, Claudia Gaigneaux, Anthoula Dicato, Mario Diederich, Marc
Published in
Cancer Letters
Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter ...
Havaki, Sophia Kotsinas, Athanassios Chronopoulos, Efstathios Kletsas, Dimitris Georgakilas, Alexandros Gorgoulis, Vassilis G.
Published in
Cancer Letters
Ionizing radiation (IR) has been described as a double-edged sword, since it is used for diagnostic and therapeutic medical applications, and at the same time it is a well known human mutagen and carcinogen, causing wide-ranging chromosomal aberrations. It is nowadays accepted that the detrimental effects of IR are not restricted only in the irradi...
Wu, Mei-Yi Fu, Junjiang Xiao, Xiuli Wu, Jingbo Wu, Ray-Chang
Published in
Cancer letters
Therapy resistance increases mortality of cancer patients and remains a major obstacle for cancer treatment. The molecular mechanism underlying the therapy resistance in cancer remains not fully understood, and there is an urgent need to identify the cause of therapy resistance. MiR-34a is an important tumor suppressor whose expression is suppresse...
Zhou, Lufang Xu, Ningning Sun, Yan Liu, Xiaoguang Margaret
Published in
Cancer letters
Cancer is a complex invasive genetic disease that causes significant mortality rate worldwide. Protein-based biopharmaceuticals have significantly extended the lives of millions of cancer patients. This article reviews the biological function and application of targeted anticancer biopharmaceuticals. We first discuss the specific antigens and core ...
Rozovski, Uri Hazan-Halevy, Inbal Keating, Michael J Estrov, Zeev
Published in
Cancer letters
Chronic lymphocytic leukemia (CLL) is the most common hematologic malignancy in the Western Hemisphere. Despite advances in research and the development of effective treatment regimens, CLL is still largely an incurable disease. Although several prognostic factors have been identified in recent years, most of the new prognostic factors are not util...
