Lorenzoni, Marco De Felice, Dario Beccaceci, Giulia Di Donato, Giorgia Foletto, Veronica Genovesi, Sacha Bertossi, Arianna Cambuli, Francesco Lorenzin, Francesca Savino, Aurora
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Published in
Cancer Letters
• Expression of ERGM40 in mouse prostate organoids promotes their survival and growth in the absence of Egf. • ERGM40 alters the extracellular signaling network of mouse prostate organoids. • Canonical Wnt pathway is substantially reduced in ERG + prostate organoids due to decreased autocrine signaling of Wnt4. • Gsk3b promotes Nkx3.1 proteolysis a...
Gleneadie, Hannah J Baker, Amy H Batis, Nikolaos Bryant, Jennifer Jiang, Yao Clokie, Samuel J H Mehanna, Hisham Garcia, Paloma Gendoo, Deena M A Roberts, Sally
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Published in
Cancer letters
The DNA demethylating agent 5-aza-2'-deoxycytidine (DAC, decitabine) has anti-cancer therapeutic potential, but its clinical efficacy is hindered by DNA damage-related side effects and its use in solid tumours is debated. Here we describe how paracetamol augments the effects of DAC on cancer cell proliferation and differentiation, without enhancing...
Kong, Xiangyi Qi, Yihang Huang, Junjie Zhao, Yang Zhan, Yongle Qin, Xuzhen Qi, Zhihong Atanda, Adejare (Jay) Zhang, Lei Wang, Jing
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Published in
Cancer Letters
There are minimal data regarding the prevalence of cancer in patients with coronavirus disease 2019 (COVID-19), as well as the incidence of severe illness and rate of mortality in COVID-19 patients with cancer. PubMed, Embase, Cochrane Library, and Web of Science were systematically searched, from database inception to July 15, 2020, for studies of...
Van de Velde, Maureen Ebroin, Marie Durré, Tania Joiret, Marc Gillot, Lionel Blacher, Silvia Geris, Liesbet Kridelka, Frédéric Noel, Agnès
Published in
Cancer letters
Solid tumors are composed of tumor cells and stromal cells including lymphatic endothelial cells (LEC), which are mainly viewed as cells forming lymphatic vessels involved in the transport of metastatic and immune cells. We here reveal a new mechanism by which tumor exposed-LEC (teLEC) exert mitogenic effects on tumor cells. Our conclusions are sup...
Revathidevi, Sundaramoorthy Murugan, Avaniyapuram Kannan Nakaoka, Hirofumi Inoue, Ituro Munirajan, Arasambattu Kannan
Published in
Cancer letters
Cervical cancer is one of the foremost common cancers in women. Human papillomavirus (HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other genetic and epigenetic factors also are involved in the underlying pathogenesis of cervical cancer. Recently, it has been reported that apolipoprotein B mRNA editing enzyme ...
Liu, Zhe
Published in
Cancer Letters
The ever-emerging developments and innovations on the advanced translational strategies for diagnosing and treating fatal human diseases are substantially re-shaping our future and improving the human health quality. This special issue published several mini-review manuscripts covering fundamental principles, techniques, devices and applications in...
Wilkie, Mark D. Anaam, Emad A. Lau, Andrew S. Rubbi, Carlos P. Jones, Terence M. Boyd, Mark T. Vlatković, Nikolina
Published in
Cancer Letters
What is already known • TP53 mutations are the most common genetic mutation in many cancers, including head and neck cancers. •Patients with mutated p53 display poor prognosis but no method exists for selectively treating these patients What this study adds •We identify and confirm that p53 status (mutant or normal) determines tumour cell metabolic...
Siegfried, Geraldine Descarpentrie, Jean Evrard, Serge Khatib, Abdel-Majid
Published in
Cancer Letters
• Proteins maturation by the proprotein convertases plays important role in inflammation-related cancer and metastasis. • Protein precursors require the proprotein convertases for the induction of inflammation. • Understanding of the molecular mechanism linking the proprotein convertases to inflammation will allow novel therapies. • Inhibitors of t...
Lopez-Luque, Judit Bertran, Esther Crosas-Molist, Eva Maiques, Oscar Malfettone, Andrea Caja, Laia Serrano, Teresa Ramos, Emilio Sanz-Moreno, Victoria Fabregat, Isabel
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The Epidermal Growth Factor Receptor (EGFR) and the Transforming Growth Factor-beta (TGF-beta) are key regulators of hepatocarcinogenesis. Targeting EGFR was proposed as a promising therapy; however, poor success was obtained in human hepatocellular carcinoma (HCC) clinical trials. Here, we describe how EGFR is frequently downregulated in HCC patie...
Lin, Chi-Chuan Suen, Kin Man Stainthorp, Amy Wieteska, Lukasz Biggs, George S. Leitão, Andrei Montanari, Carlos A. Ladbury, John E.
Published in
Cancer Letters
• Shc binds to Erk and sequesters it from MAPK signal transduction. • Inhibition of PTB domain binding to EGFR prevents release of Erk. • In silico screen identified indomethacin, a known NSAID, as an inhibitor for Shc PTB. • Indomethacin indirectly inhibits MAPK signalling by depriving the pathway of Erk. • The approach to MAPK inhibition through ...
