Published in Cancer letters
Solid tumors are composed of tumor cells and stromal cells including lymphatic endothelial cells (LEC), which are mainly viewed as cells forming lymphatic vessels involved in the transport of metastatic and immune cells. We here reveal a new mechanism by which tumor exposed-LEC (teLEC) exert mitogenic effects on tumor cells. Our conclusions are sup...
Published in Cancer letters
Cervical cancer is one of the foremost common cancers in women. Human papillomavirus (HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other genetic and epigenetic factors also are involved in the underlying pathogenesis of cervical cancer. Recently, it has been reported that apolipoprotein B mRNA editing enzyme ...
Published in Cancer Letters
The ever-emerging developments and innovations on the advanced translational strategies for diagnosing and treating fatal human diseases are substantially re-shaping our future and improving the human health quality. This special issue published several mini-review manuscripts covering fundamental principles, techniques, devices and applications in...
Published in Cancer Letters
What is already known • TP53 mutations are the most common genetic mutation in many cancers, including head and neck cancers. •Patients with mutated p53 display poor prognosis but no method exists for selectively treating these patients What this study adds •We identify and confirm that p53 status (mutant or normal) determines tumour cell metabolic...
Published in Cancer Letters
• Proteins maturation by the proprotein convertases plays important role in inflammation-related cancer and metastasis. • Protein precursors require the proprotein convertases for the induction of inflammation. • Understanding of the molecular mechanism linking the proprotein convertases to inflammation will allow novel therapies. • Inhibitors of t...
The Epidermal Growth Factor Receptor (EGFR) and the Transforming Growth Factor-beta (TGF-beta) are key regulators of hepatocarcinogenesis. Targeting EGFR was proposed as a promising therapy; however, poor success was obtained in human hepatocellular carcinoma (HCC) clinical trials. Here, we describe how EGFR is frequently downregulated in HCC patie...
Published in Cancer Letters
• Shc binds to Erk and sequesters it from MAPK signal transduction. • Inhibition of PTB domain binding to EGFR prevents release of Erk. • In silico screen identified indomethacin, a known NSAID, as an inhibitor for Shc PTB. • Indomethacin indirectly inhibits MAPK signalling by depriving the pathway of Erk. • The approach to MAPK inhibition through ...
Published in Cancer Letters
• Cancer stem cells (CSCs) are the culprits for cancer drug resistance and cancer relapse. • Dietary phytochemicals (curcumin, resveratrol, epigallocatechin gallate) target CSCs. • Repositioned drugs (metformin, niclosamide, thioridazine) target CSCs. • Phytochemical-drug combinations targeting CSCs may exhibit synergistic effects.
Published in Cancer Letters
Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors and apoptosis inducers. Here, we translate their application in colorectal cancer (CRC). MALDI-TOF-MS analysis identified both compounds as reversible tubulin binde...
Published in Cancer letters
The covalent attachment of β-D-N-acetylglucosamine monosaccharides (O-GlcNAc) to serine/threonine residues of nuclear and cytoplasmic proteins is a major regulatory mechanism in cell physiology. Aberrant O-GlcNAc modification of signaling proteins, metabolic enzymes, and transcriptional and epigenetic regulators has been implicated in cancer. Relen...
