Gao, Bin Wang, Lijuan Zhang, Na Han, Miaomiao Zhang, Yubo Liu, Huancai Sun, Dongli Xiao, Xiaolong Liu, Yifei
Published in
Cancer Cell International
ObjectiveOur study aims to investigate the mechanism of the miR-129-5p/SPN axis in clear cell renal cell carcinoma (ccRCC), providing a novel direction for the targeted therapy of ccRCC.MethodsBioinformatics methods were implemented to find the differentially expressed genes (DEGs) associated with ccRCC from TCGA database. qRT-PCR was performed to ...
Zhang, Yalei Li, Ye Chen, Kun Qian, Ling Wang, Peng
Published in
Cancer Cell International
It has been intensively reported that the immunosuppressive tumor microenvironment (TME) results in tumor resistance to immunotherapy, especially immune checkpoint blockade and chimeric T cell antigen therapy. As an emerging therapeutic agent, oncolytic viruses (OVs) can specifically kill malignant cells and modify immune and non-immune TME compone...
Wang, Zhao Chen, Meiting Fang, Xiaojie Hong, Huangming Yao, Yuyi Huang, He
Published in
Cancer Cell International
BackgroundBurkitt lymphoma (BL) is a highly aggressive, fast-growing B-cell non-Hodgkin's lymphoma, manifested in several subtypes, including sporadic, endemic, and immunodeficiency-related forms, the mechanism of which is still not clear. Abundant evidence reported that KIF15 was involved in the progression of human cancer. The emphasis of this st...
Li, Li Zhao, Weidong
Published in
Cancer Cell International
BackgroundNon-coding RNAs (ncRNAs) have been identified as key regulators during the pathogenesis and development of cancers. However, most of ncRNAs have never been explored in acute myeloid leukemia (AML).MethodsGene expression was evaluated by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot. Functional assays were perf...
Faghfoori, Zeinab Faghfoori, Mohammad Hasan Saber, Amir Izadi, Azimeh Yari Khosroushahi, Ahmad
Published in
Cancer Cell International
BackgroundColorectal cancer (CRC), with a growing incidence trend worldwide, is resistant to apoptosis and has uncontrolled proliferation. It is recently reported that probiotic microorganisms exert anticancer effects. The genus Bifidobacterium, one of the dominant bacterial populations in the gastrointestinal tract, has received increasing attenti...
Shen, Dexin Fang, Yayun Zhou, Fenfang Deng, Zhao Qian, Kaiyu Wang, Gang Xiao, Yu Ju, Lingao Wang, Xinghuan
Published in
Cancer Cell International
BackgroundCDCA3 is an important component of the E3 ligase complex with SKP1 and CUL1, which could regulate the progress of cell mitosis. CDCA3 has been widely identified as a proto-oncogene in multiple human cancers, however, its role in promoting human bladder urothelial carcinoma has not been fully elucidated.MethodsBioinformatic methods were us...
Deng, Huan Hang, Qingqing Shen, Dijian Zhang, Yibi Chen, Ming
Published in
Cancer Cell International
PurposeExploring the molecular mechanisms of lung adenocarcinoma (LUAD) is beneficial for developing new therapeutic strategies and predicting prognosis. This study was performed to select core genes related to LUAD and to analyze their prognostic value.MethodsMicroarray datasets from the GEO (GSE75037) and TCGA-LUAD datasets were analyzed to ident...
Fu, Yihan Sun, Hong
Published in
Cancer Cell International
Competing endogenous RNAs (ceRNAs) can indirectly regulate gene expression by competitively binding to microRNA(miRNA) through miRNA response elements (MREs) to affect miRNA-induced gene regulation, which is of great biological significance. Among them, circular RNA (circRNA) has become a hotspot due to its highest binding capacity. A specific circ...
Hu, Yang Xie, Hong Liu, Yankun Liu, Weiying Liu, Min Tang, Hua
Published in
Cancer Cell International
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12935-021-01958-0
Issac, Joby Raveendran, Pooja S. Das, Ani V.
Published in
Cancer Cell International
Regulatory factor X1 (RFX1) is an evolutionary conserved transcriptional factor that influences a wide range of cellular processes such as cell cycle, cell proliferation, differentiation, and apoptosis, by regulating a number of target genes that are involved in such processes. On a closer look, these target genes also play a key role in tumorigene...
