Mehrpour Layeghi, Sepideh Arabpour, Maedeh Esmaeili, Rezvan Naghizadeh, Mohammad Mehdi Tavakkoly Bazzaz, Javad Shakoori, Abbas
Published in
Cancer Cell International
BackgroundLuminal subtype is the most common subgroup of breast cancer (BC), accounting for more than 70% of this cancer. Long non-coding RNAs (lncRNAs) are a group of RNAs which play critical roles in diverse cellular processes. It is proved that dysregulation of them can contribute to the development of various cancers, including BC. LINC00961 wa...
Zheng, Qingling Dai, Xin Fang, Wei Zheng, Yan Zhang, Jin Liu, Yanxiang Gu, Donghua
Published in
Cancer Cell International
BackgroundCompelling evidences reported the role of microRNAs (miRNAs) in ovarian cancer. However, little was known regarding the molecular mechanism of miR-367 in ovarian cancer. This study intended to investigate the role and regulatory mechanism of miR-367 in ovarian cancer involving lysophosphatidic acid receptor-1 (LPA1).MethodsPotentially reg...
Xu, Weifeng Chen, Beibei Ke, Dianshan Chen, Xiaobing
Published in
Cancer Cell International
BackgroundColorectal cancer ranks among the most lethal diseases worldwide. Although much progress has been made in research and treatment of colorectal cancer in recent years, the underlying mechanisms related to migration of the cancer cells and the reason for chemoresistance still remain unclear. In this research, we explored the underlying effe...
Li, Yang Li, Hai Wei, Xin
Published in
Cancer Cell International
BackgroundProstate cancer is one of the leading causes of cancer death in males. Recent studies have reported aberrant expression of lncRNAs in prostate cancer. This study explores the role of LINC00261 in prostate cancer progression.MethodsThe differentially expressed genes, transcription factors, and lncRNAs related to prostate cancer were predic...
Rong, Jiping Xu, Lu Hu, Yinying Liu, Fan Yu, Yanrong Guo, Hongyan Ni, Xudong Huang, Yanqin Zhao, Lin Wang, Zhigang
...
Published in
Cancer Cell International
BackgroundDysfunction of microRNAs (miRNAs) is a major cause of aberrant expression of inflammatory cytokines and contributes to macrophage polarization. Proinflammatory M1 macrophages promote T helper (Th) 1 responses and show tumoricidal activity, whereas M2 macrophages display regulatory functions in tissue repair and remodeling and promote Th2 ...
Liu, Jiajia Yang, Tao Zhang, Ying Wang, Shuhui
Published in
Cancer Cell International
BackgroundWe aimed to explore the roles of basic leucine zipper and W2 domains (BZW) 2 in the human papillomavirus-infected laryngeal papillomatosis.MethodsIn the present study, BZW 2 knockdown and overexpressed cell lines were constructed. CCK-8 and colony formation assays were used to determine cell proliferation. Caspase-3 activity and nucleosom...
Chen, Wangsheng Hong, Lan Hou, Changlong Wang, Yibin Wang, Fei Zhang, Jianhua
Published in
Cancer Cell International
BackgroundMicroRNAs (miRNAs) are important regulators for cancer cell proliferation. miR-585 has been shown to inhibit the proliferation of several types of cancer, however, little is known about its role in human glioma cells.MethodsmiR-585 levels in human glioma clinical samples and cell lines were examined by quantitative real-time PCR (qRT-PCR)...
Fan, Changru Yuan, Qiulan Liu, Guifeng Zhang, Yuliang Yan, Maojun Sun, Qingxu Zhu, Chaoyu
Published in
Cancer Cell International
BackgroundColorectal cancer (CRC) is one of the most general malignant tumors. Accumulating evidence implied that long non-coding RNA Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) participated in the tumorigenesis of CRC. However, the effect of MALAT1 in drug-resistance needed to be further illustrated.MethodsLevels of MALAT1, mic...
Zhang, Jing Xiao, Chunhua Feng, Zhenbo Gong, Yun Sun, Baohua Li, Zhongqi Lu, Yimin Fei, Xiaojie Wu, Weizhu Sun, Xiaoping
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Published in
Cancer Cell International
PurposeIncreasing evidence has shown that the transcription factor SOX4 is closely associated with the development and progression of many malignant tumors. However, the effect of SOX4 on breast cancer is unclear. In this study, we purposed to investigate the role of SOX4 in the growth and metastasis in breast cancer and the underlying mechanism. M...
Cui, Jie Wang, Liping Zhong, Waisheng Chen, Zhen Chen, Jie Yang, Hong Liu, Genglong
Published in
Cancer Cell International
BackgroundRecurrence remains a major obstacle to long-term survival of laryngeal squamous cell carcinoma (LSCC). We conducted a genome-wide integrated analysis of methylation and the transcriptome to establish methylation-driven genes prognostic signature (MDGPS) to precisely predict recurrence probability and optimize therapeutic strategies for LS...
