Leung, Jessica C Cassimeris, Lynne
Published in
Cancer biology & therapy
Paclitaxel is a widely used anti-cancer treatment that disrupts cell cycle progression by blocking cells in mitosis. The block at mitosis, with spindles assembled from short microtubules, is surprising given paclitaxel's microtubule stabilizing activity and the need to depolymerize long interphase microtubules prior to spindle formation. Cells must...
Terasawa, Hiroyuki Kinugasa, Hideaki Ako, Soichiro Hirai, Mami Matsushita, Hiroshi Uchida, Daisuke Tomoda, Takeshi Matsumoto, Kazuyuki Horiguchi, Shigeru Kato, Hironari
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Published in
Cancer biology & therapy
In recent years, liquid biopsy for blood and body fluid in cancer patients has attracted attention. However, there have been few reports of liquid biopsy focusing on urine of pancreatic ductal adenocarcinoma (PDAC). In 56 patients with PDAC, DNA was extracted from urine and plasma prior to treatment, and KRAS mutations were analyzed with droplet di...
Habicht, Juri Mooneyham, Ashley Shetty, Mihir Zhang, Xiaonan Shridhar, Vijayalakshmi Winterhoff, Boris Zhang, Ying Cepela, Jason Starr, Timothy Lou, Emil
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Published in
Cancer biology & therapy
UNC-45A is an ubiquitously expressed protein highly conserved throughout evolution. Most of what we currently know about UNC-45A pertains to its role as a regulator of the actomyosin system. However, emerging studies from both our and other laboratories support a role of UNC-45A outside of actomyosin regulation. This includes studies showing that U...
Fan, Xiaoqin Wang, Yujie Song, Jian Wu, Hanwei Yang, Ming Lu, Lu Weng, Xin Liu, Lusha Nie, Guohui
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Cancer biology & therapy
Nasopharyngeal carcinoma (NPC) is a high-risk head and neck cancer with poor clinical outcomes and insufficient treatments. The mouse double minute 2 homolog (MDM2) is the main molecular target in the clinical treatment of cancer. Indeed, MDM2 negatively regulates p53 through ubiquitin-dependent degradation. Thus, inhibition of MDM2-p53 interaction...
Gao, Li-Min Zhao, Sha Zhang, Wen-Yan Wang, Mi Li, Hui-Fang Lizaso, Anle Liu, Wei-Ping
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Cancer biology & therapy
Limited studies are available on the molecular pathogenesis of Epstein-Barr virus (EBV)-associated T or natural killer (NK) cell lymphoproliferative disorders (EBV+T/NK-LPD). In this retrospective study, we aim to elucidate the mutation profile of EBV+T/NK-LPD using capture-based targeted sequencing with a panel consisting of 64 lymphoma-related ge...
Shi, Jiaqi Guan, Xin Zhan, Fei Liu, Chao Li, Zhiwei Yao, Yuanfei Wang, Bojun Lou, Changjie Zhang, Yanqiao
Published in
Cancer biology & therapy
Constitutive photomorphogenesis 9 (COP9) signalosome 6 (CSN6) plays an essential role in tumor development. The present study aims to demonstrate that CSN6 is an important biomarker and has prognostic value for patients with pancreatic ductal adenocarcinoma (PDAC). We analyzed CSN6 expression levels in PDAC and adjacent non-cancerous tissues using ...
Cheng, Zhiheng Dai, Yifeng Pang, Yifan Jiao, Yang Liu, Yan Cui, Longzhen Qian, Tingting Quan, Liang Cui, Wei Pan, Yue
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Published in
Cancer biology & therapy
Epithelial growth factor-like 7 (EGFL7) is a secretory protein with a well-characterized role in angiogenesis and the oncogenesis of certain solid tumors. Overexpression of EGFL7 is associated with adverse prognosis in patients with cytogenetically normal acute myeloid leukemia (CN-AML). However, whether this association persists after allogeneic h...
Collado, Loren Brownell, Isaac
Published in
Cancer biology & therapy
The financial cost of cancer treatment in the United States is astronomically high and is expected to rise. The economic burden of cancer care increasingly falls on the patients. Patients thus experience "financial toxicity" of cancer care that can have catastrophic consequences on health and quality of life. Here we examine the results reported by...
Ovcharenko, Dmitriy Chitjian, Catrina Kashkin, Alex Fanelli, Alex Ovcharenko, Victor
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Cancer biology & therapy
Dichloroacetate (DCA) is an inhibitor of pyruvate dehydrogenase kinase (PDK) that has been shown to reverse the Warburg effect and cause tumor cell death. Clinical research into the anti-cancer activity of DCA revealed high dosage requirements and reports of toxicity. While there have been subsequent mechanistic investigations, a search for DCA alt...
Watanabe, Shinichiro Noma, Kazuhiro Ohara, Toshiaki Kashima, Hajime Sato, Hiroaki Kato, Takuya Urano, Shinichi Katsube, Ryoichi Hashimoto, Yuuri Tazawa, Hiroshi
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Published in
Cancer biology & therapy
Cancer-associated fibroblasts (CAFs) are strongly implicated in tumor progression, including in the processes of tumorigenesis, invasion, and metastasis. The targeting of CAFs using various therapeutic approaches is a novel treatment strategy; however, the efficacy of such therapies remains limited. Recently, near-infrared photoimmunotherapy (NIR-P...
