Patras, Laura Ionescu, Aura Elena Munteanu, Cristian Hajdu, Renata Kosa, Andreea Porfire, Alina Licarete, Emilia Rauca, Valentin Florian Sesarman, Alina Luput, Lavinia
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Published in
Cancer Biology & Therapy
Tailoring extracellular vesicles (EVs) as targeted drug delivery systems to enhance the therapeutic efficacy showed superior advantage over liposomal therapies. Herein, we developed a novel nanotool for targeting B16.F10 murine melanoma, based on EVs stabilized with Polyethylene glycol (PEG) and loaded with doxorubicin (DOX). Small EVs were efficie...
Idogawa, Masashi Koizumi, Masayo Hirano, Tomomi Tange, Shoichiro Nakase, Hiroshi Tokino, Takashi
Published in
Cancer biology & therapy
We often encounter situations in which data from the TCGA that have been analyzed in papers we read or reviewed cannot be reproduced, even when TCGA datasets are used, especially in survival analyses. Therefore, we attempted to confirm the data source for TCGA survival analysis and found that several websites used to analyze the survival data of TC...
Jhaveri, Aakash V. Zhou, Lanlan Ralff, Marie D. Lee, Young S. Navaraj, Arunasalam Carneiro, Benedito A. Safran, Howard Prabhu, Varun V. Ross, Eric A. Lee, Seulki
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Published in
Cancer Biology & Therapy
The five-year survival rate for pancreatic ductal adenocarcinoma (PDAC) has remained a dismal 9% for approximately 40 years with an urgent need for novel therapeutic interventions. ONC201 is the founding member of the imipridone class, comprised of orally bioavailable small molecules that have shown efficacy in multiple tumor types both in animal m...
Yan, Anqi Chen, Guanhao Nie, Jichan
Published in
Cancer biology & therapy
Statement of RetractionArticle title: DGUOK-AS1 promotes the proliferation cervical cancer through regulating miR-653-5p/EMSYAuthors: Yan A, Chen G, and Nie, J.Journal: Cancer Biology & TherapyDOI: https://doi.org/10.1080/15384047.2020.1775445In the version of DGUOK-AS1 promotes the proliferation cervical cancer through regulating miR-653-5p/EMSY b...
Awah, Chidiebere U Winter, Jan Mazdoom, Claudiane M Ogunwobi, Olorunseun O.
Published in
Cancer Biology & Therapy
Nop2/Sun RNA methyltransferase (NSUN6) is an RNA 5-methyl cytosine (5mC) transferase with little information known of its function in cancer and response to cancer therapy. Here, we show that NSUN6 methylates both large and small RNA in glioblastoma and controls glioblastoma response to temozolomide with or without influence of the MGMT promoter st...
Ray, Jocelyn E Ralff, Marie D Jhaveri, Aakash Zhou, Lanlan Dicker, David T Ross, Eric A El-Deiry, Wafik S
Published in
Cancer biology & therapy
ONC201 demonstrated promising activity in patients with advanced endometrial cancer in a Phase I clinical trial. ONC201 activates the integrated stress response (ISR) and upregulates TRAIL and its receptor DR5. We hypothesized ONC201 upregulation of DR5 could sensitize tumors to TRAIL and combination of ONC201 and TRAIL would lead to enhanced cell ...
Sallustio, Fabio Curci, Claudia Solimando, Antonio Giovanni Leone, Patrizia Pontrelli, Paola Gesualdo, Loreto Vacca, Angelo Racanelli, Vito Gallone, Anna
Published in
Cancer biology & therapy
Monoclonal gammopathy of undetermined significance (MGUS) represents the pre-clinical stage of Multiple Myeloma (MM) with the 5% of MGUS progresses to MM. Although the progression from MGUS to MM has not been completely characterized, it is possible to monitor the DNA modifications of patients diagnosed with MGUS to detect early specific genomic ab...
Pan, Li Zhang, Ruijie Ma, Ling Pierson, Christopher R. Finlay, Jonathan L. Li, Chenglong Lin, Jiayuh
Published in
Cancer Biology & Therapy
Persistent activation of signal transducer and activator of transcription 3 (STAT3) is frequently reported in cancers and plays important roles in tumor progression. Therefore, directly targeting persistent STAT3 signaling is an attractive cancer therapeutic strategy. The aim of this study is to test the inhibitory efficacy of novel STAT3 small mol...
Kuang, Weilu Jiang, Wuzhong Chen, Yinyun Tian, Yifu Liu, Zhengzheng
Published in
Cancer Biology & Therapy
A maximal surgical resection followed by radiotherapy and chemotherapy with temozolomide (TMZ) as the representative agent is the standard therapy for gliomas. However, tumor cell resistance to radiotherapy and chemotherapy leads to poor prognosis and high mortality in patients with glioma. In the present study, we demonstrated that JARID2 was down...
Tarasiuk, Aleksandra Mackiewicz, Tomasz Małecka-Panas, Ewa Fichna, Jakub
Published in
Cancer Biology & Therapy
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies, with poor prognosis resulting mostly from late diagnosis. Surgery remains the most effective treatment and early detection significantly increases the overall survival. Biomarkers used for diagnosis and to monitor the response to treatment, such as carbohydrate antigen 19...
