Zhang, Yifan Zhu, Xiaoxue Zhan, Yan Li, Xiaojiao Liu, Cai Zhu, Yunting Zhang, Hong Wei, Haijing Xia, Yu Sun, Hongbin
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Published in
British journal of clinical pharmacology
We investigated the impacts of CYP2C19 polymorphisms on pharmacokinetics and pharmacodynamics of vicagrel in healthy Chinese subjects. CYP2C19 extensive metabolizers (EMs), intermediate metabolizers (IMs) and poor metabolizers (PMs; 16 subjects/group) participated in a randomized, open-label, 2-period cross-over study. Each study period lasted 7 da...
Kerbusch, Thomas Li, Hanbin Wada, Russell Jauslin, Petra M Wenning, Larissa
Published in
British journal of clinical pharmacology
In this exposure-response analysis, the dosing regimen for tildrakizumab, an antibody for treating moderate-to-severe chronic plaque psoriasis, was determined using data from 3 randomised controlled trials (P05495/NCT01225731: phase 2b, n = 355; reSURFACE 1/NCT01722331: phase 3, n = 772; reSURFACE 2/NCT01729754: phase 3, n = 1090). A maximum drug e...
Shariati, Laleh Amouheidari, Alireza Naji Esfahani, Hajar Abed, Alireza Haghjooy Javanmard, Shaghayegh Laher, Ismail Ghasemi, Ahmad Vaseghi, Golnaz
Published in
British journal of clinical pharmacology
Breast cancer is the most frequently occurring cancer in women. Lumpectomy followed by radiotherapy is suggested to be as effective as a total mastectomy. Radiation-induced dermatitis often occurs as a result of breast radiotherapy. Recent studies suggest that doxepin has promising anti-inflammatory properties. This study was undertaken to evaluate...
Bonneville, Edouard Gautier-Veyret, Elodie Ihl, Cordelia Hilleret, Marie-Noelle Baudrant, Magalie Fonrose, Xavier Stanke-Labesque, Françoise
Published in
British journal of clinical pharmacology
Tacrolimus is the cornerstone of the therapeutic immunosuppressive strategy in liver transplantation. The inter-individual and intra-individual variability of its trough blood concentrations is a surrogated biomarker of allograft rejection. Here we described two cases of patients with liver transplant who exhibited increases of tacrolimus blood tro...
Geers, Lisanne M Pozhidaev, Ivan V Ivanova, Svetlana A Freidin, Maxim B Schmidt, Amand F Cohen, Dan Boiko, Anastasiia S Paderina, Diana Z Fedorenko, Olga Yu Semke, Arkadiy V
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Published in
British journal of clinical pharmacology
Hyperprolactinaemia, a common adverse effect of antipsychotic drugs, is primarily linked to blockade of dopamine D2 receptors in the pituitary gland. Certain antipsychotic drugs, such as, for example risperidone and paliperidone, are more likely to induce hyperprolactinaemia compared to others. This effect is probably caused by a relatively high bl...
Rolfo, Christian Isambert, Nicolas Italiano, Antoine Molife, L Rhoda Schellens, Jan H M Blay, Jean-Yves Decaens, Thomas Kristeleit, Rebecca Rosmorduc, Olivier Demlova, Regina
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Published in
British journal of clinical pharmacology
Olaparib, a potent oral poly(ADP-ribose) polymerase inhibitor, is partially hepatically cleared. We investigated the pharmacokinetics (PK) and safety of olaparib in patients with mild or moderate hepatic impairment to provide dosing recommendations. This Phase I open-label study assessed the PK, safety and tolerability of single doses of olaparib 3...
Abdou, Yara Pandey, Manu Sarma, Maithreyi Shah, Shrunjal Baron, Jeffrey Ernstoff, Marc S
Published in
British journal of clinical pharmacology
Immune checkpoints are cell surface molecules that initiate regulatory pathways which have powerful control of CD8+ cytolytic T cell activity. Antagonistic and agonistic antibodies engaging these molecules have demonstrated profound impact on immune activation and have entered clinical use for the treatment of a variety of diseases. Over the past d...
Dasyam, Nathaniel George, Philip Weinkove, Robert
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British journal of clinical pharmacology
Lymphocytes such as T-cells can be genetically transduced to express a synthetic chimeric antigen receptor (CAR) that re-directs their cytotoxic activity against a tumour-expressed antigen of choice. Autologous (patient-derived) CAR T-cells have been licensed to treat certain relapsed and refractory B-cell malignancies, and numerous CAR T-cell prod...
Mirzaev, Karin B Kiselev, Yury Ivashchenko, Dmitriy V Otdelenov, Vitaly Sychev, Dmitry A
Published in
British journal of clinical pharmacology
Mattishent, Katharina Loke, Yoon Kong
Published in
British journal of clinical pharmacology
