Santos, Joana António, Natália Rocha, Marília Fortuna, Ana
Published in
British journal of clinical pharmacology
Worldwide observational studies are evidencing discordance between guidelines and real-world practice regarding direct oral anticoagulant drug (DOAC) doses. This systematic review summarizes and evaluate DOACs use in real-world practice. This review was performed following the preferred reporting items for systematic reviews and meta-analyses (PRIS...
Groeneveld, Geert Jan Martin, Jennifer H
Published in
British journal of clinical pharmacology
Afzal, Saima Kishvar Hasan, Syed Shahzad Babar, Zaheer Ud-Din
Published in
British journal of clinical pharmacology
Patient-reported outcomes (PROs) are a distinctive method of evaluating patient response to health care or treatment. This systematic review aimed to analyse the impact of PROs in patients on direct oral anticoagulant (DOAC) treatment, prescribed for any indication (e.g. venous thromboembolism treatment or atrial fibrillation) using controlled tria...
McClenathan, Bruce M Edwards, Kathryn M
Published in
British journal of clinical pharmacology
van der Heijden, Charlotte D C C Duizer, Marleen L Fleuren, Hanneke W H A Veldman, Bart A Sprong, Tom Dofferhoff, Anton T S M Kramers, Cornelis
Published in
British journal of clinical pharmacology
Intravenous flucloxacillin is one of the most frequently used high-dose penicillin therapies in hospitalized patients, forming the cornerstone treatment of invasive Staphylococcus aureus infection. Being a nonreabsorbable anion, flucloxacillin has been suggested to cause hypokalaemia, although the frequency and magnitude of this unwanted effect is ...
Wang, Jianwen Huang, Jie Li, Wei Tang, Shiqi Sun, Jian Zhang, Xianming Liu, Jun Yi, Bin Liu, Jishi Zhang, Xingfei
...
Published in
British journal of clinical pharmacology
Type 2 diabetes mellitus (T2DM) is commonly complicated by renal impairment. Polyethylene glycol loxenatide (PEX168) is a novel long-acting glucagon-like peptide-1 receptor agonist for T2DM. PEX168 pharmacokinetics was studied to identify requirements for dose-modification in T2DM complicated by renal impairment. This was a single-centre, open-labe...
Fiedler-Kelly, Jill B Cohen-Barak, Orit Morris, Denise N Ludwig, Elizabeth Rasamoelisolo, Michele Shen, Honglue Levi, Micha
Published in
British journal of clinical pharmacology
Fremanezumab is a fully humanized IgG2 Δa/κ monoclonal antibody specific for calcitonin gene-related peptide developed and approved for the preventive treatment of migraine in adults. The population pharmacokinetics (PK) of fremanezumab were characterized in healthy subjects and patients with chronic migraine and episodic migraine, including the ef...
Rijsbergen, Melanie Rijneveld, Rianne Todd, Marina Feiss, Gary L Kouwenhoven, Stijn T P Quint, Koen D van Alewijk, Dirk C J G de Koning, Maurits N C Klaassen, Erica S Burggraaf, Jacobus
...
Published in
British journal of clinical pharmacology
To assess safety and tolerability and explore pharmacodynamics and efficacy of omiganan in external anogenital warts (AGW) and vulvar high-grade squamous intraepithelial lesions (HSIL). Two randomized controlled trials in patients with external AGW and vulvar HSIL were conducted. Patients received topical omiganan 2.5% or placebo gel once daily for...
Hill, Raymond G
Published in
British journal of clinical pharmacology
This review paper is based on a talk given at the BPS Winter Meeting in 2018 derived from the Home Office Report on the workings of the UK Psychoactive Substances Act (PSA) published in November 2018 (1) ( . The review deals with the context in which the PSA 2016 arose and how this piece of legislation differs from other UK drug regulations. It att...
Haag, Melanie Lehmann, Audrey Hersberger, Kurt Eduard Schneider, Marie-Paule Gauchet, Aurélie Vrijens, Bernard Arnet, Isabelle Allenet, Benoît
Published in
British journal of clinical pharmacology
We translated the ABC adherence taxonomy (i.e., seven terms and their corresponding definitions) published by Vrijens et al. (2012) into French (F) and German (G) without changing the original meaning with the aim to promote a standardised taxonomy for medication adherence to French- and German-speaking researchers and clinicians. A Delphi survey w...
