McNally, Ryan J Faconti, Luca Cecelja, Marina Farukh, Bushra Floyd, Christopher N Chowienczyk, Philip J
Published in
British journal of clinical pharmacology
Plasma renin activity (PRA) is regarded as a marker of sodium and fluid homeostasis in patients with primary hypertension. Whether effects of diuretics on PRA differ according to class of diuretic, whether diuretics lead to a sustained increase in PRA, and whether changes in PRA relate to those in blood pressure (BP) is unknown. We performed a syst...
Qiu, Kun-Yin Liao, Xiong-Yu Huang, Ke Wu, Ruo-Hao Xu, Hong-Gui Xu, Lu-Hong Li, Yang Weng, Wen-Jun Zhou, Dun-Hua Fang, Jian-Pei
...
Published in
British journal of clinical pharmacology
The purpose of this study is to examine the safety and efficacy of eltrombopag as first-line treatment for thrombocytopenia among paediatric patients after haematopoietic stem cell transplantation (HSCT). Forty-three childhood patients with thrombocytopenia after HSCT who received eltrombopag were retrospectively analysed. Eltrombopag was began at ...
Gobburu, Jogarao V S
Published in
British journal of clinical pharmacology
Asiimwe, Innocent G Zhang, Eunice J Osanlou, Rostam Jorgensen, Andrea L Pirmohamed, Munir
Published in
British journal of clinical pharmacology
Numerous algorithms have been developed to guide warfarin dosing and improve clinical outcomes. We reviewed the algorithms available for various populations and the covariates, performances and risk of bias of these algorithms. We systematically searched MEDLINE up to 20 May 2020 and selected studies describing the development, external validation ...
Ofori, Kenneth Bhagat, Govind Rai, Alex J
Published in
British journal of clinical pharmacology
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma, and it constitutes biologically heterogeneous entities. Standard first-line therapies cure ~60% of patients, the rest being either refractory or experiencing relapse. Currently, there are no robust predictive biomarkers of therapeutic response. Heterogeneity of...
Fujita, Kenji Kushida, Kazuki Okada, Hiroshi Moles, Rebekah J Chen, Timothy F
Published in
British journal of clinical pharmacology
Quality indicators (QIs) are an important mechanism by which health services can be evaluated. We aimed to develop a set of QIs for pharmacist home visit services and assess their measurement properties. A three-step procedure was applied: (1) Selection of existing content-validated QIs from the international literature and the development of QIs b...
Fullerton, James N Della Pasqua, Oscar Likic, Robert
Published in
British journal of clinical pharmacology
Tsuda, Yasuhiro Grimaldi, Christine Huang, Fenglei Benediktus, Ewald Yagi, Nobutaka Padula, Steven J Jang, In-Jin Steffgen, Jürgen
Published in
British journal of clinical pharmacology
To evaluate the safety, pharmacokinetics and pharmacodynamics of BI 655064 in healthy Chinese and Japanese subjects after administration of single doses of 80-240 mg and multiple dosing of 240 mg once weekly over 4 weeks. Two phase 1, double-blind, placebo-controlled studies were conducted (single-rising doses of BI 655064 in Chinese/Japanese male ...
Junqueira, Daniela R Rowe, Brian H
Published in
British journal of clinical pharmacology
To assess whether randomized clinical trials (RCTs) proposed to evaluate the treatment of patients with COVID-19 with hydroxychloroquine (HQ) or chloroquine early in the pandemic included plans to measure outcomes that would translate into meaningful efficacy/effectiveness and safety outcomes. The World Health Organization International Clinical Tr...
Shrestha, Shakti Poudel, Arjun Steadman, Kathryn Nissen, Lisa
Published in
British journal of clinical pharmacology
Older patients with life-limiting illness (LLI) and limited life expectancy (LLE) continue to receive potentially inappropriate medicines, consequently deprescribing is often necessary. However, deprescribing in this population can be complex and challenging. Therefore, we aimed to investigate the evidence for outcomes of deprescribing intervention...
