Sayer, Ben Bortone, Barbara Sharland, Mike Hsia, Yingfen
Published in
British journal of clinical pharmacology
High consumption of irrational fixed-dose combination (FDC) antibiotics may pose a threat of antimicrobial resistance. In India, ampicillin-cloxacillin was the second highest sold FDC antibiotic behind amoxicillin and clavulanic acid. There remain, however, questions about its efficacy and safety and a lack of regulatory approval. We undertook a li...
Robertsen, Ida Woillard, Jean-Baptiste Åsberg, Anders
Published in
British journal of clinical pharmacology
Isoardi, Katherine Z Polkinghorne, Gregory Harris, Keith Isbister, Geoffrey K
Published in
British journal of clinical pharmacology
With rising use worldwide, pregabalin is increasingly implicated in poisoning deaths. We aimed to investigate the clinical effects and complications of pregabalin poisoning. This is a retrospective review of patients presenting with pregabalin poisoning to two tertiary toxicology units from 1 July 2014 to 30 June 2019. Patients were identified from...
Calvo Fernández, Ester Zhu, Lucie Y
Published in
British journal of clinical pharmacology
SARS-CoV-2 is the novel coronavirus behind the COVID-19 pandemic. Since its emergence, the global scientific community has mobilized to study this virus, and an overwhelming effort to identify COVID-19 treatments is currently ongoing for a variety of therapeutics and prophylactics. In order to better understand these efforts, we compiled a list of ...
Bertin, Célian Delorme, Jessica Riquelme, Marie Peyrière, Hélène Brousse, Georges Eschalier, Alain Ardid, Denis Chenaf, Chouki Authier, Nicolas
Published in
British journal of clinical pharmacology
Several addictovigilance studies have described the off-label use of morphine sulfate (MS) for nonchronic pain in opioid use disorder (OUD) patients as an alternative to conventional opioid substitution treatments (OSTs). This study primarily sought to compare the incidence of unintentional opioid-related overdose in the year following the prescrip...
Leufkens, Hubert G
Published in
British journal of clinical pharmacology
Baker, E H
Published in
British journal of clinical pharmacology
Glucocorticoids are highly effective medicines in the treatment of inflammatory disorders. However they cause severe adverse reactions, particularly where taken at high doses systemically for prolonged periods. Systemic glucocorticoids are therefore given at dosage sufficient to control the disease, then withdrawn as fast as is possible to minimise...
Jones, Terry E
Published in
British journal of clinical pharmacology
Hines, Philip A Guy, Richard H Brand, Angela Humphreys, Anthony J Papaluca-Amati, Marisa
Published in
British journal of clinical pharmacology
Regulatory science underpins the objective evaluation of medicinal products. It is therefore imperative that regulatory science and expertise remain at the cutting edge so that innovations of ever-increasing complexity are translated safely and swiftly into effective, high-quality therapies. We undertook a comprehensive examination of the evolution...
Pimentel, Juan Laurie, Cassandra Cockcroft, Anne Andersson, Neil
Published in
British journal of clinical pharmacology
Remdesivir is 1 of the repurposed drugs under investigation to treat patients with COVID-19. Clinicians and decision-makers need a summary of the most recent evidence. This scoping review maps the evidence on the efficacy, effectiveness and safety of remdesivir for patients with COVID-19, up to 14 September 2020. Our scoping review searched Pubmed,...
