Fan, Bu-Fang Hao, Bo Dai, Yun-Da Xue, Li Shi, Yan-Wei Liu, Lu Xuan, Shou-Min Yang, Ning Wang, Xiao-Guang Zhao, Hu
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Published in
Brain pathology (Zurich, Switzerland)
Stress-induced neuroepigenetic programming gains growing more and more interest in the studies of the etiology of posttraumatic stress disorder (PTSD). However, seldom attention is focused on DNA demethylation in fear memory generalization, which is the core characteristic of PTSD. Here, we show that ten-eleven translocation protein 3 (TET3), the m...
Fisher, Robert A Miners, J Scott Love, Seth
Published in
Brain pathology (Zurich, Switzerland)
Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional changes to the cerebral vasculature contribute to disease pathology and cognitive decline in Alzheimer's disease (AD). In this review, we discuss the contribution of cerebral amyloid angiopathy and non-amyloid small vessel disease in AD, and the accompanying ch...
Laville, David Godfraind, Catherine Dal Col, Pierre Vassal, François Boutet, Claire Péoc'h, Michel Forest, Fabien
Published in
Brain pathology (Zurich, Switzerland)
Saito, Yoshihiko Baba, Shimpei Komaki, Hirofumi Nishino, Ichizo
Published in
Brain pathology (Zurich, Switzerland)
Murakami, Aya Koga, Shunsuke Sekiya, Hiroaki Oskarsson, Björn Boylan, Kevin Petrucelli, Leonard Josephs, Keith A Dickson, Dennis W
Published in
Brain pathology (Zurich, Switzerland)
This study aimed to assess and compare the burden of transactive response DNA-binding protein of 43 kDa (TDP-43) pathology and clinical features of amyotrophic lateral sclerosis (ALS) in three age groups. All cases were from the Mayo Clinic brain bank for neurodegenerative disorders and most were followed longitudinally in the ALS Clinic. Cases wit...
Littau, Jessica Lisa Velilla, Lina Hase, Yoshiki Villalba-Moreno, Nelson David Hagel, Christian Drexler, Dagmar Osorio Restrepo, Santiago Villegas, Andres Lopera, Francisco Vargas, Sergio
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Published in
Brain pathology (Zurich, Switzerland)
We studied small vessel disease (SVD) pathology in Familial Alzheimer's disease (FAD) subjects carrying the presenilin 1 (PSEN1) p.Glu280Ala mutation in comparison to those with sporadic Alzheimer's disease (SAD) as a positive control for Alzheimer's pathology and Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalo...
Woltering, Niklas Albers, Anne Müther, Michael Stummer, Walter Paulus, Werner Hasselblatt, Martin Holling, Markus Thomas, Christian
Published in
Brain pathology (Zurich, Switzerland)
Hemangioblastomas (HBs) of the central nervous system are highly vascular neoplasms that occur sporadically or as a manifestation of von Hippel-Lindau (VHL) disease. Despite their benign nature, HBs are clinically heterogeneous and can be associated with significant morbidity due to mass effects of peritumoral cysts or tumor progression. Underlying...
Salvany, Sara Casanovas, Anna Piedrafita, Lídia Gras, Sílvia Calderó, Jordi Esquerda, Josep E
Published in
Brain pathology (Zurich, Switzerland)
Early misfolded superoxide dismutase 1 (mfSOD1) accumulation, motor neuron (MN) degeneration, and microgliosis are hallmark pathological features in SOD1G93A amyotrophic lateral sclerosis (ALS) mice. Because of the different vulnerabilities of distinct MN subtypes, degenerating and surviving MNs coexist in different proportions during disease progr...
Miyahara, Hiroaki Akagi, Akio Riku, Yuichi Sone, Jun Otsuka, Yasushi Sakai, Motoko Kuru, Satoshi Hasegawa, Masato Yoshida, Mari Kakita, Akiyoshi
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Published in
Brain pathology (Zurich, Switzerland)
Subacute sclerotic panencephalitis (SSPE) is a refractory neurological disorder after exposure to measles virus. Recently, SSPE cases have been treated with antiviral therapies, but data on the efficacy are inconclusive. Abnormal tau accumulation has been reported in the brain tissue of SSPE cases, but there are few reports in which this is amply d...
Preusse, Corinna Marteau, Theodore Fischer, Norina Hentschel, Andreas Sickmann, Albert Lang, Sven Schneider, Udo Schara-Schmidt, Ulrike Meyer, Nancy Ruck, Tobias
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Published in
Brain pathology (Zurich, Switzerland)
Patients suffering from immune-mediated necrotizing myopathies (IMNM) harbor, the pathognomonic myositis-specific auto-antibodies anti-SRP54 or -HMGCR, while about one third of them do not. Activation of chaperone-assisted autophagy was described as being part of the molecular etiology of IMNM. Endoplasmic reticulum (ER)/sarcoplasmic reticulum (SR)...
