Abey, Ajantha Davies, Danielle Goldsbury, Claire Buckland, Michael Valenzuela, Michael Duncan, Thomas
Published in
Brain pathology (Zurich, Switzerland)
Some aged community dogs acquire a degenerative syndrome termed Canine Cognitive Dysfunction (CCD) that resembles human dementia because of Alzheimer's Disease (AD), with comparable cognitive and behavioral deficits. Dogs also have similar neuroanatomy, share our domestic environment and develop amyloid-β plaques, making them likely a valuable ecol...
Lucas, Calixto-Hope G Villanueva-Meyer, Javier E Whipple, Nicholas Oberheim Bush, Nancy Ann Cooney, Tabitha Chang, Susan McDermott, Michael Berger, Mitchel Cham, Elaine Sun, Peter P
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Published in
Brain pathology (Zurich, Switzerland)
"Myxoid glioneuronal tumor, PDGFRA p.K385-mutant" is a recently described tumor entity of the central nervous system with a predilection for origin in the septum pellucidum and a defining dinucleotide mutation at codon 385 of the PDGFRA oncogene replacing lysine with either leucine or isoleucine (p.K385L/I). Clinical outcomes and optimal treatment ...
Huang, Peixian Zhou, Qiuping Lin, Qiongyu Lin, Lanfen Wang, Huifang Chen, Xuan Jiang, Shuqi Fu, Hui Deng, Yiyu
Published in
Brain pathology (Zurich, Switzerland)
Neuroinflammation is thought to play a pivotal role in the pathogenesis of periventricular white matter (PWM) damage (PWMD) induced by neonatal sepsis. Because the complement cascade is implicated in inflammatory response, this study was carried out to determine whether C3a is involved in PWMD, and, if so, whether it would induce axonal hypomyelina...
Pouget, Celso Hergalant, Sébastien Lardenois, Emilie Lacomme, Stéphanie Houlgatte, Rémi Carpentier, Catherine Dehais, Caroline Rech, Fabien Taillandier, Luc Sanson, Marc
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Published in
Brain pathology (Zurich, Switzerland)
Anaplastic oligodendroglioma (AO), IDH-mutant and 1p/19q codeleted (IDHmut+/1p19qcodel), is a high-grade glioma with only limited prognostic markers. The primary objective of this study was to evaluate, by immunohistochemistry, the prognostic value of two proliferation markers, MCM6 and Ki-67, in a large series of IDHmut+/1p19qcodel AO included in ...
Nahar, Khayrun Lebouvier, Thibaud Andaloussi Mäe, Maarja Konzer, Anne Bergquist, Jonas Zarb, Yvette Johansson, Bengt Betsholtz, Christer Vanlandewijck, Michael
Published in
Brain pathology (Zurich, Switzerland)
Primary familial brain calcification (PFBC) is an age-dependent and rare neurodegenerative disorder characterized by microvascular calcium phosphate deposits in the deep brain regions. Known genetic causes of PFBC include loss-of-function mutations in genes involved in either of three processes-platelet-derived growth factor (PDGF) signaling, phosp...
Louis, David N Wesseling, Pieter Aldape, Kenneth Brat, Daniel J Capper, David Cree, Ian A Eberhart, Charles Figarella-Branger, Dominique Fouladi, Maryam Fuller, Gregory N
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Published in
Brain pathology (Zurich, Switzerland)
cIMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to evaluate and make practical recommendations on recent advances in the field of CNS tumor classification, particularly in light of the rapid progress in molecular insights into these neoplasms. For Round 2 of its deliberations, cIMPACT-...
Suemoto, Claudia K Leite, Renata E P Ferretti-Rebustini, Renata E L Rodriguez, Roberta D Nitrini, Ricardo Pasqualucci, Carlos A Jacob-Filho, Wilson Grinberg, Lea T
Published in
Brain pathology (Zurich, Switzerland)
Sebastián-Serrano, Álvaro Simón-García, Ana Belmonte-Alfaro, Alicia Pose-Utrilla, Julia Santos-Galindo, María Del Puerto, Ana García-Guerra, Lucía Hernández, Ivó H Schiavo, Giampietro Campanero, Miguel R
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Published in
Brain pathology (Zurich, Switzerland)
Huntington's disease (HD) is an inherited progressive neurodegenerative disease characterized by brain atrophy particularly in the striatum that produces motor impairment, and cognitive and psychiatric disturbances. Multiple pathogenic mechanisms have been proposed including dysfunctions in neurotrophic support and calpain-overactivation, among oth...
Bieniek, Kevin F Blessing, Melissa M Heckman, Michael G Diehl, Nancy N Serie, Amanda M Paolini, Michael A 2nd Boeve, Bradley F Savica, Rodolfo Reichard, R Ross Dickson, Dennis W
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Published in
Brain pathology (Zurich, Switzerland)
Chronic traumatic encephalopathy is a debilitating neurodegenerative disorder associated with repetitive traumatic brain injuries often sustained through prior contact sport participation. The frequency of this disorder in a diverse population, including amateur athletes, is unknown. Primary historical obituary and yearbook records were queried for...
Ferris, Sean P Velazquez Vega, Jose Aboian, Mariam Lee, Julieann C Van Ziffle, Jessica Onodera, Courtney Grenert, James P Saunders, Tara Chen, Yunn-Yi Banerjee, Anu
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Published in
Brain pathology (Zurich, Switzerland)
High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication (HGNET BCOR ex15 ITD) is a recently proposed tumor entity of the central nervous system (CNS) with a distinct methylation profile and characteristic genetic alteration. The complete spectrum of histologic features, accompanying genetic alterations, clinical outcomes, and...
