Oyanagi, Kiyomitsu Kinoshita, Michiaki Suzuki-Kouyama, Emi Inoue, Teruhiko Nakahara, Asa Tokiwai, Mika Arai, Nobutaka Satoh, Jun-Ichi Aoki, Naoya Jinnai, Kenji
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Published in
Brain pathology (Zurich, Switzerland)
The brains of 10 Japanese patients with adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) encompassing hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) and pigmentary orthochromatic leukodystrophy (POLD) and eight Japanese patients with Nasu-Hakola disease (N-HD) and five age-matched Japanese control...
Bielle, Franck Ducray, François Mokhtari, Karima Dehais, Caroline Adle-Biassette, Homa Carpentier, Catherine Chanut, Anaïs Polivka, Marc Poggioli, Sylvie Rosenberg, Shai
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Published in
Brain pathology (Zurich, Switzerland)
The integrated diagnosis of anaplastic oligodendroglioma, IDH mutant and 1p/19q co-deleted, grade III (O3id ) is a histomolecular entity that WHO 2016 classification distinguished from other diffuse gliomas by specific molecular alterations. In contrast, its cell portrait is less well known. The present study is focused on intertumor and intratumor...
Pathak, Pankaj Kumar, Anupam Jha, Prerana Purkait, Suvendu Faruq, Mohammed Suri, Ashish Suri, Vaishali Sharma, Mehar C Sarkar, Chitra
Published in
Brain pathology (Zurich, Switzerland)
Pilocytic astrocytomas occur rarely in adults and show aggressive tumor behavior. However, their underlying molecular-genetic events are largely uncharacterized. Hence, 59 adult pilocytic astrocytoma (APA) cases of classical histology were studied (MIB-1 LI: 1%-5%). Analysis of BRAF alterations using qRT-PCR, confirmed KIAA1549-BRAF fusion in 11 (1...
Qi, Xin-Rui Luchetti, Sabina Verwer, Ronald W H Sluiter, Arja A Mason, Matthew R J Zhou, Jiang-Ning Swaab, Dick F
Published in
Brain pathology (Zurich, Switzerland)
Altered levels of steroids have been reported in the brain, cerebral spinal fluid and plasma of patients with mood disorders. Neuroimaging studies have reported both functional and structural alterations in mood disorders, for instance in the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC). In order to determine whether t...
Chen, Li-Jin Wang, Yueh-Jan Chen, Jeng-Rung Tseng, Guo-Fang
Published in
Brain pathology (Zurich, Switzerland)
Hydrocephalus is a common neurological disorder in children characterized by abnormal dilation of cerebral ventricles as a result of the impairment of cerebrospinal fluid flow or absorption. Clinical presentation of hydrocephalus varies with chronicity and often shows cognitive dysfunction. Here we used a kaolin-induction method in rats and studied...
Johann, Pascal D Hovestadt, Volker Thomas, Christian Jeibmann, Astrid Heß, Katharina Bens, Susanne Oyen, Florian Hawkins, Cynthia Pierson, Christopher R Aldape, Kenneth
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Published in
Brain pathology (Zurich, Switzerland)
Rhabdoid phenotype and loss of SMARCB1 expression in a brain tumor are characteristic features of atypical teratoid/rhabdoid tumors (ATRT). Rare non-rhabdoid brain tumors showing cribriform growth pattern and SMARCB1 loss have been designated cribriform neuroepithelial tumor (CRINET). Small case series suggest that CRINETs may have a relatively fav...
Tauziede-Espariat, Arnault Parfait, Béatrice Besnard, Aurore Lacombe, Joëlle Pallud, Johan Tazi, Sanaa Puget, Stéphanie Lot, Guillaume Terris, Benoît Cohen, Joëlle
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Published in
Brain pathology (Zurich, Switzerland)
Clear cell meningioma (CCM) is a rare grade II histopathological subtype that usually occurs in young patients and displays high recurrence rate. Germline SMARCE1 mutations have been described in hereditary forms of this disease and more recently in small syndromic and sporadic CCM series. The diagnostic value of SMARCE1 in distinguishing between C...
Hayashida, Shotaro Masaki, Katsuhisa Yonekawa, Tomomi Suzuki, Satoshi O Hiwatashi, Akio Matsushita, Takuya Watanabe, Mitsuru Yamasaki, Ryo Suenaga, Toshihiko Iwaki, Toru
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Published in
Brain pathology (Zurich, Switzerland)
NMO frequently and extensively affects spinal white matter in addition to central gray matter, especially in PC and LC, where isolated perivascular lesions with astrocyte endfoot protein loss may emerge. Spinal white matter involvement may also appear in early NMO, similar to cerebral white matter lesions.
Miners, J Scott Clarke, Polly Love, Seth
Published in
Brain pathology (Zurich, Switzerland)
Clusterin, also known as apoJ, is a lipoprotein abundantly expressed within the CNS. It regulates Aβ fibril formation and toxicity and facilitates amyloid-β (Aβ) transport across the blood-brain barrier. Genome-wide association studies have shown variations in the clusterin gene (CLU) to influence the risk of developing sporadic Alzheimer's disease...
Hata, Yukiko Yoshida, Koji Kinoshita, Koshi Nishida, Naoki
Published in
Brain pathology (Zurich, Switzerland)
Inherited heart disease causing electric instability in the heart has been suggested to be a risk factor for sudden unexpected death in epilepsy (SUDEP). The purpose of this study was to reveal the correlation between epilepsy-related sudden unexpected death (SUD) and inherited heart disease. Twelve epilepsy-related SUD cases (seven males and five ...
