Zhao, Qianru Wang, Shanshan Lv, Zuopeng Zupanic, Anze Guo, Shuxian Zhao, Quanyu Jiang, Ling Yu, Yadong
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Biotechnology advances
Microbes have proven to be robust workhorses for the large-scale production of many chemicals. Especially, high-value biochemicals (e.g., natural pigments, unsaturated fatty acids) that cannot be derived from fossil fuels, can be produced by engineered microbes. There is a growing interest in both academia and industry to find new technologies that...
Jerabek, Tobias Keysberg, Christoph Otte, Kerstin
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Biotechnology advances
Chinese hamster ovary (CHO) cells have been the predominant host for recombinant protein production over the past decades with major efforts directed towards cell line engineering to increase amount and quality of biopharmaceutics. Emerging omics approaches and corresponding techniques now allow an extensive characterization of cellular expression ...
Ribeaucourt, David Bissaro, Bastien Lambert, Fanny Lafond, Mickael Berrin, Jean-Guy
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Biotechnology advances
From Egyptian mummies to the Chanel n°5 perfume, fatty aldehydes have long been used and keep impacting our senses in a wide range of foods, beverages and perfumes. Natural sources of fatty aldehydes are threatened by qualitative and quantitative variability while traditional chemical routes are insufficient to answer the society shift toward more ...
Pundir, Meenakshi Papagerakis, Silvana De Rosa, Maria C Chronis, Nikos Kurabayashi, Katsuo Abdulmawjood, Shahad Prince, Mark Edward P Lobanova, Liubov Chen, Xiongbiao Papagerakis, Petros
...
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Biotechnology advances
The internally driven 24-h cycle in humans, called circadian rhythm, controls physiological, metabolic, and hormonal processes, and is tied to the circadian clocks ticking in most of the cells and tissues. The central clock, located in suprachiasmatic nuclei of the hypothalamus, is directly influenced by external cues, particularly light, and entra...
Mutanda, Ishmael Sun, Jianzhong Jiang, Jianxiong Zhu, Daochen
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Biotechnology advances
Aromatic compounds are ubiquitous in nature; they are the building blocks of abundant lignin, and constitute a substantial proportion of synthetic chemicals and organic pollutants. Uptake and degradation of aromatic compounds by bacteria have relevance in bioremediation, bio-based plastic recycling, and microbial conversion of lignocellulosic bioma...
Danielewicz, Natalia Rosato, Francesca Dai, Wenyue Römer, Winfried Turnbull, W Bruce Mairhofer, Juergen
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Biotechnology advances
Glycan-recognizing toxins play a significant role in the etiology of many diseases afflicting humanity. The carbohydrate recognition domains of these toxins play essential roles in the virulence of many microbial organisms with multiple modes of action, from promoting pore formation to facilitating the entry of toxic enzymatic subunits into the hos...
Chia, Natalie Lee, Sang Yup Tong, Yaojun
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Biotechnology advances
Chemical induction is one of the most common modalities used to manipulate gene expression in living systems. However, chemical induction can be toxic or expensive that compromise the economic feasibility when it comes to industrial-scale synthetic biology applications. These complications have driven the pursuit of better induction systems. Optoge...
Virdis, Bernardino D Hoelzle, Robert Marchetti, Angela Boto, Santiago T Rosenbaum, Miriam A Blasco-Gómez, Ramiro Puig, Sebastià Freguia, Stefano Villano, Marianna
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Biotechnology advances
The market of biobased products obtainable via fermentation processes has steadily increased over the past few years, driven by the need to create a decarbonized economy. To date, industrial fermentation (IF) employs either pure or mixed microbial cultures (MMC), whereby the type of the microbial catalysts and the used feedstock affect metabolic pa...
Mapstone, Lydia J Leite, Mara N Purton, Saul Crawford, Ian A Dartnell, Lewis
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Biotechnology advances
Establishing the first human presence on Mars will be the most technically challenging undertaking yet in the exploration beyond our planet. The remoteness of Mars from Earth, the inhospitable surface conditions including low atmospheric pressure and cold temperatures, and the need for basic resources including water, pose a formidable challenge to...
Cámara, Elena Olsson, Lisbeth Zrimec, Jan Zelezniak, Aleksej Geijer, Cecilia Nygård, Yvonne
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Biotechnology advances
The use of renewable plant biomass, lignocellulose, to produce biofuels and biochemicals using microbial cell factories plays a fundamental role in the future bioeconomy. The development of cell factories capable of efficiently fermenting complex biomass streams will improve the cost-effectiveness of microbial conversion processes. At present, inhi...
